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80810 Fluka

Piperine

purum, ≥98.0% (TLC)

Synonym: 1-Piperoylpiperidine

  • CAS Number 94-62-2

  • Empirical Formula (Hill Notation) C17H19NO3

  • Molecular Weight 285.34

  •  Beilstein Registry Number 90741

  •  EC Number 202-348-0

  •  MDL number MFCD00005839

  •  PubChem Substance ID 24887584

  • Popular Documents:  FTNMR (PDF)  

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Properties

grade   purum
assay   ≥98.0% (TLC)
mp   128-132 °C
  131-135 °C(lit.)
Gene Information   human ... CYP3A4(1576)

Price and Availability

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
22
Safety Statements (Europe) 
22-24/25
WGK Germany 
3
RTECS 
TN2321500

Protocols & Articles

Peer-Reviewed Papers

References

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Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers. Volak LP, Hanley MJ, Masse G, et al. Br. J. Clin. Pharmacol. 75(2), 450-62, (2013)

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Piperine, a dietary phytochemical, inhibits angiogenesis. Doucette CD, Hilchie AL, Liwski R, et al. J. Nutr. Biochem. 24(1), 231-9, (2013)

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Coupling of a high-resolution monoamine oxidase-A inhibitor assay and HPLC-SPE-NMR for advanced bioactivity profiling of plant extracts. Grosso C, Jäger AK, and Staerk D Phytochem. Anal. 24(2), 141-7, (2013)

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Piperine impairs cell cycle progression and causes reactive oxygen species-dependent apoptosis in rectal cancer cells. Yaffe PB, Doucette CD, Walsh M, et al. Exp. Mol. Pathol. 94(1), 109-14, (2013)

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Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells. Do MT, Kim HG, Choi JH, et al. Food Chem. 141(3), 2591-9, (2013)

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[Studies of effective part group of piperine to regulating lipid]. Bao XM, Na SS, and Lu JK Zhongguo Zhong Yao Za Zhi 38(6), 909-13, (2013)

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Amaranthus roxburghianus root extract in combination with piperine as a potential treatment of ulcerative colitis in mice. Nirmal SA, Ingale JM, Pattan SR, et al. J. Integr. Med. 11(3), 206-12, (2013)

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Combination therapy of piperine and phenytoin in maximal electroshock induced seizures in mice: isobolographic and biochemical analysis. Saraogi P, Vohora D, Khanam R, et al. Drug Res. (Stuttg.) 63(6), 311-8, (2013)

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Effect of piperine on antihyperglycemic activity and pharmacokinetic profile of nateglinide. Sama V, Nadipelli M, Yenumula P, et al. Arzneimittelforschung 62(8), 384-8, (2012)

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Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-κB, C/EBP and AP-1 signaling pathways in murine macrophages. Kim HG, Han EH, Jang WS, et al. Food Chem. Toxicol. 50(7), 2342-8, (2012)

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Piperine, an LXRα antagonist, protects against hepatic steatosis and improves insulin signaling in mice fed a high-fat diet. Jwa H, Choi Y, Park UH, et al. Biochem. Pharmacol. 84(11), 1501-10, (2012)

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Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Srinivasan K Crit. Rev. Food Sci. Nutr 47(8), 735-48, (2007)

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Repeated dosing of piperine induced gene expression of P-glycoprotein via stimulated pregnane-X-receptor activity and altered pharmacokinetics of diltiazem in rats. Qiang F, Kang KW, and Han HK Biopharm. Drug Dispos. 33(8), 446-54, (2012)

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Anti-apoptotic and anti-inflammatory effect of Piperine on 6-OHDA induced Parkinson's rat model. Shrivastava P, Vaibhav K, Tabassum R, et al. J. Nutr. Biochem. 24(4), 680-7, (2013)

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Cancer stem cells: potential target for bioactive food components. Kim YS, Farrar W, Colburn NH, Milner JA. J. Nutr. Biochem. 23, 691-698, (2012)

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GABAA receptor modulation by piperine and a non-TRPV1 activating derivative. Khom S, Strommer B, Schöffmann A, et al. Biochem. Pharmacol. 85(12), 1827-36, (2013)

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A plausible explanation for enhanced bioavailability of P-gp substrates in presence of piperine: simulation for next generation of P-gp inhibitors. Singh DV, Godbole MM, and Misra K J. Mol. Model. 19(1), 227-38, (2013)

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Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms. da Cruz GM, Felipe CF, Scorza FA, et al. Pharmacol. Biochem. Behav. 104, 144-53, (2013)

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Antiparasitic efficacy of piperine against Argulus spp. on Carassius auratus (Linn. 1758): in vitro and in vivo study. Kumar A, Raman RP, Kumar K, et al. Parasitol. Res. 111(5), 2071-6, (2012)

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Piper nigrum: micropropagation, antioxidative enzyme activities, and chromatographic fingerprint analysis for quality control. Ahmad N, Abbasi BH, Rahman Iu, et al. Appl. Biochem. Biotechnol. 169(7), 2004-15, (2013)

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Piperine suppresses cerebral ischemia-reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-κB in middle cerebral artery occlusion rat model. Vaibhav K, Shrivastava P, Javed H, et al. Mol. Cell Biochem. 367(1-2), 73-84, (2012)

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Black pepper and piperine reduce cholesterol uptake and enhance translocation of cholesterol transporter proteins. Duangjai A, Ingkaninan K, Praputbut S, et al. J. Nat. Med. 67(2), 303-10, (2013)

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Effect of curcumin on LDL oxidation in vitro, and lipid peroxidation and antioxidant enzymes in cholesterol fed rabbits. Mahfouz MM, Zhou Q, and Kummerow FA Int. J. Vitam. Nutr. Res. 81(6), 378-91, (2011)

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Piperine inhibits cytokine production by human peripheral blood mononuclear cells. Chuchawankul S, Khorana N, and Poovorawan Y Genet. Mol. Res. 11(1), 617-27, (2012)

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Efficient modulation of γ-aminobutyric acid type A receptors by piperine derivatives. Schöffmann A, Wimmer L, Goldmann D, et al. J. Med. Chem. 57(13), 5602-19, (2014)

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Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1. Wang YM, Lin W, Chai SC, et al. Toxicol. Appl. Pharmacol. 272(1), 96-107, (2013)

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Physiological barriers to the oral delivery of curcumin. Berginc K, Trontelj J, Basnet NS, et al. Pharmazie 67(6), 518-24, (2012)

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Piperine potentiates the protective effects of curcumin against chronic unpredictable stress-induced cognitive impairment and oxidative damage in mice. Rinwa P and Kumar A Brain Res. 1488, 38-50, (2012)

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Screening of antidiabetic and antihyperlipidemic potential of oil from Piper longum and piperine with their possible mechanism. Kumar S, Sharma S, and Vasudeva N Expert Opin. Pharmacother. 14(13), 1723-36, (2013)

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Enhanced oral absorption of 20(S)-protopanaxadiol by self-assembled liquid crystalline nanoparticles containing piperine: in vitro and in vivo studies. Jin X, Zhang ZH, Sun E, et al. Int. J. Nanomedicine 8, 641-52, (2013)

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Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation. Wightman EL, Reay JL, Haskell CF, et al. Br. J. Nutr. 112(2), 203-13, (2014)

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Piperine and curcumin exhibit synergism in attenuating D-galactose induced senescence in rats. Banji D, Banji OJ, Dasaroju S, et al. Eur. J. Pharmacol. 703(1-3), 91-9, (2013)

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Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson's disease. Al-Baghdadi OB, Prater NI, Van der Schyf CJ, et al. Bioorg. Med. Chem. Lett. 22(23), 7183-8, (2012)

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Piper nigrum and piperine: an update. Meghwal M and Goswami TK Phytother Res. 27(8), 1121-30, (2013)

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A comprehensive review on pharmacotherapeutics of herbal bioenhancers. Dudhatra GB, Mody SK, Awale MM, et al. ScientificWorldJournal 2012, 637953, (2012)

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Inhibition by TRPA1 agonists of compound action potentials in the frog sciatic nerve. Matsushita A, Ohtsubo S, Fujita T, et al. Biochem. Biophys. Res. Commun. 434(1), 179-84, (2013)

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Piperine inhibits LPS induced expression of inflammatory mediators in RAW 264.7 cells. Ying X, Yu K, Chen X, et al. Cell. Immunol. 285(1-2), 49-54, (2013)

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Evaluation of the effect of piperine per se on blood glucose level in alloxan-induced diabetic mice. Atal S, Agrawal RP, Vyas S, et al. Acta Pol. Pharm. 69(5), 965-9, (2012)

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Effect of piperine on the pharmacokinetics and pharmacodynamics of glimepiride in normal and streptozotocin-induced diabetic rats. Veeresham C, Sujatha S, and Rani TS Nat. Prod. Commun. 7(10), 1283-6, (2012)

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Development and validation of simultaneous estimation method for curcumin and piperine by RP-UFLC. Ramaswamy S, Kuppuswamy G, Dwarampudi P, et al. Pak. J. Pharm. Sci. 27(4), 901-6, (2014)

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Piperine enhances the efficacy of TRAIL-based therapy for triple-negative breast cancer cells. Abdelhamed S, Yokoyama S, Refaat A, et al. Anticancer Res. 34(4), 1893-9, (2014)

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Piperine induces apoptosis of lung cancer A549 cells via p53-dependent mitochondrial signaling pathway. Lin Y, Xu J, Liao H, et al. Tumour Biol. 35(4), 3305-10, (2014)

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Protective effect of piperine on electrophysiology abnormalities of left atrial myocytes induced by hydrogen peroxide in rabbits. Liu Y, Zhang Y, Lin K, et al. Life Sci. 94(2), 99-105, (2014)

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Merck 14,7472

Beil. 20,V,3,469

Aldrich MSDS 1, 1502:B / Arctander, 2627 / Corp MSDS 1 (2), 2848:B / FT-IR 2 (2), 2986:A / FT-IR 1 (2), 362:C / FT-NMR 1 (2), 1379:B / Fenaroli / IR-Spectra (3), 1073:G / IR-Spectra (2), 939:B / NMR-Reference 2 (2), 341:C / RegBook 1 (2), 2011:D / RegBook 27 (2), 2011:D / Sigma FT-IR 1 (2), 854:B / Structure Index 1, 321:B:1

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P49007 Piperine, 97%

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