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88491 Fluka

Thiobenzamide

purum, ≥98.0% (N)

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Properties

Related Categories Building Blocks, Chemical Synthesis, Organic Building Blocks, Sulfur Compounds, Thiocarbonyl Compounds More...
grade   purum
assay   ≥98.0% (N)
color   yellow
mp   113-117 °C(lit.)
  113-117 °C

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Suggested Laboratory Gloves


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Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
Hazard Codes (Europe) 
T
Risk Statements (Europe) 
25
Safety Statements (Europe) 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
CV5860000

Protocols & Articles

Peer-Reviewed Papers

References

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Hydrogen sulfide enhances ulcer healing in rats. Wallace, J.L., et al. FASEB J. 21, 4070-4076, (2007)

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Metabolism of thioamides by Ralstonia pickettii TA. Dodge AG, Richman JE, Johnson G, et al. Appl. Environ. Microbiol. 72(12), 7468-76, (2006)

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Facile synthesis of nitriles via manganese oxide promoted oxidative dehydrosulfurization of primary thioamides. Yamaguchi K, Yajima K, and Mizuno N Chem. Commun. (Camb.) 48(91), 11247-9, (2012)

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2,2'-Dithiobisbenzamides and 2-benzisothiazolones, two new classes of antiretroviral agents: SAR and mechanistic considerations. Domagala JM, Gogliotti R, Sanchez JP, et al. Drug Des. Discov. 15(1), 49-61, (1997)

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Chemical Research in Toxicology. In this issue. Chem. Res. Toxicol. 21(7), 1320-1, (2008)

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Presence of flavin-containing monooxygenase in rat brain. Bhamre S and Ravindranath V Biochem. Pharmacol. 42(2), 442-4, (1991)

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Protein targets of reactive metabolites of thiobenzamide in rat liver in vivo. Ikehata K, Duzhak TG, Galeva NA, et al. Chem. Res. Toxicol. 21(7), 1432-42, (2008)

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Flavin-containing monooxygenase activity can be inhibited by nitric oxide-mediated S-nitrosylation. Ryu SD, Yi HG, Cha YN, et al. Life Sci. 75(21), 2559-72, (2004)

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Covalent modification of microsomal lipids by thiobenzamide metabolites in vivo. Ji T, Ikehata K, Koen YM, et al. Chem. Res. Toxicol. 20(4), 701-8, (2007)

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Involvement of CYP3A1, 2B1, and 2E1 in C-8 hydroxylation and CYP 1A2 and flavin-containing monooxygenase in N-demethylation of caffeine; identified by using inducer treated rat liver microsomes that are characterized with testosterone metabolic patterns. Chung WG, Roh HK, Kim HM, et al. Chem. Biol. Interact. 113(1), 1-14, (1998)

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Effects of the herbicide chlorthiamid on the olfactory mucosa. Eriksson C and Brittebo EB Toxicol. Lett. 76(3), 203-8, (1995)

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Structure-activity relationships for a series of thiobenzamide influenza fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclohexylmethylamine. Yu KL, Torri AF, Luo G, et al. Bioorg. Med. Chem. Lett. 12(23), 3379-82, (2002)

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Placental peroxidase--further purification of the enzyme and oxidation of thiobenzamide. Joseph P, Srinivasan NS, and Kulkarni AP Placenta 14(3), 309-19, (1993)

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Persistent chemopreventive effect of S-adenosyl-L-methionine on the development of liver putative preneoplastic lesions induced by thiobenzamide in diethylnitrosamine-initiated rats. Simile MM, Saviozzi M, De Miglio MR, et al. Carcinogenesis 17(7), 1533-7, (1996)

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Role of lipoxygenase in xenobiotic metabolism: sulfoxidation of thiobenzamide by purified soybean lipoxygenase. Naidu AK and Kulkarni AP Res. Commun. Chem. Pathol. Pharmacol. 71(2), 175-88, (1991)

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Gender differences in hepatic expression of flavin-containing monooxygenase isoforms (FMO1, FMO3, and FMO5) in mice. Falls JG, Blake BL, Cao Y, et al. J. Biochem. Toxicol. 10(3), 171-7, (1995)

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Possible role of the acetone-inducible cytochrome P-450IIE1 in the metabolism and hepatotoxicity of thiobenzamide. Chieli E, Saviozzi M, Puccini P, et al. Arch. Toxicol. 64(2), 122-7, (1990)

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Determination of FAD-binding domain in flavin-containing monooxygenase 1 (FMO1). Kubo A, Itoh S, Itoh K, et al. Arch. Biochem. Biophys. 345(2), 271-7, (1997)

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Peroxidase-catalyzed S-oxygenation: mechanism of oxygen transfer for lactoperoxidase. Doerge DR, Cooray NM, and Brewster ME Biochemistry 30(37), 8960-4, (1991)

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ETM-ANN approach application for thiobenzamide and quinolizidine derivatives. Saracoglu M, Kandemirli F, Kovalishyn V, et al. J. Biomed. Biotechnol. 2010, doi:10.1155/2010/693031, (2010)

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Relative hepatotoxicity of 2-(substituted phenyl)thiazoles and substituted thiobenzamides in mice: evidence for the involvement of thiobenzamides as ring cleavage metabolites in the hepatotoxicity of 2-phenylthiazoles. Mizutani T and Suzuki K Toxicol. Lett. 85(2), 101-5, (1996)

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Determination of p-methylthiobenzamide and p-methylthiobenzamide-S-oxide from rat plasma using solid-phase extraction and high-performance liquid chromatography. Davidson VP and Traiger GJ J. Chromatogr. A 567(1), 213-20, (1991)

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Thiobenzamide-induced hepatotoxicity: effects of substituents and route of administration on the nature and extent of liver injury. Grossman SJ, Patrick DH, Kornbrust D, et al. Toxicol. Appl. Pharmacol. 111(3), 388-408, (1991)

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Conformational polymorphism in N-(4'-methoxyphenyl)- 3-bromothiobenzamide. Bashkirava A, Andrews PC, Junk PC, et al. Chem. Asian J. 2(4), 530-8, (2007)

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Induction of flavin-containing monooxygenase (FMO1) by a polycyclic aromatic hydrocarbon, 3-methylcholanthrene, in rat liver. Chung WG, Park CS, Roh HK, et al. Mol. Cells 7(6), 738-41, (1997)

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Potent inhibition of alcohol self-administration in alcohol-preferring rats by a κ-opioid receptor antagonist. Cashman JR and Azar MR J. Pharmacol. Exp. Ther. 350(1), 171-80, (2014)

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Beil. 9,IV,1376

Aldrich MSDS 1, 1697:D / Corp MSDS 1 (2), 3325:C / FT-IR 1 (2), 415:C / FT-IR 2 (2), 3094:A / FT-NMR 1 (2), 1472:C / IR-Spectra (3), 1106:D / IR-Spectra (2), 965:A / NMR-Reference 2 (2), 383:C / RegBook 1 (2), 2093:B / Structure Index 1, 331:B:2

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148229 Thiobenzamide, 98%

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