Ursolic acid

Papers

Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes. Shaukath Ara Khanum et al Bioorg. Med. Chem. Lett. 15, 4100-4, (2005)

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Three new triterpenes from Nerium oleander and biological activity of the isolated compounds. Liwei Fu et al J. Nat. Prod. 68, 198-206, (2005)

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Bacterial biofilm inhibitors from Diospyros dendo. Jin-Feng Hu et al J. Nat. Prod. 69, 118-20, (2006)

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Protein Tyrosine Phosphatase-1B Inhibitory Activity of Isoprenylated Flavonoids Isolated from Erythrina mildbraedii. MinKyun Na, et al. J. Nat. Prod. 69, 1572-1576, (2006)

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Bioactive triterpenoids from Salvia species. Gülaçti Topçu et al J. Nat. Prod. 69, 482-7, (2006)

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Anti-tumor agents 255: novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agents. Jin Tatsuzaki et al Bioorg. Med. Chem. 15, 6193-9, (2007)

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Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. Long Cui et al J. Nat. Prod. 70, 1039-42, (2007)

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9,19-cyclolanostane derivatives from the roots of Actaea pachypoda. Zulfiqar Ali et al J. Nat. Prod. 70, 107-10, (2007)

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Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds. Sara Hoet et al J. Nat. Prod. 70, 1360-3, (2007)

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Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies. Xiaoan Wen et al J. Med. Chem. 51, 3540-54, (2008)

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Modulating G-protein coupled receptor/G-protein signal transduction by small molecules suggested by virtual screening. Christina M Taylor et al J. Med. Chem. 51, 5297-303, (2008)

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Flavanones from the stem bark of Erythrina abyssinica. Long Cui et al Bioorg. Med. Chem. 16, 10356-62, (2008)

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Pharmacomodulation on the 3-acetylursolic acid skeleton: Design, synthesis, and biological evaluation of novel N-{3-[4-(3-aminopropyl)piperazinyl]propyl}-3-O-acetylursolamide derivatives as antimalarial agents. Simone C B Gnoatto et al Bioorg. Med. Chem. 16, 771-82, (2008)

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Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities. Zhang, Y.-N.; et al. Bioorg. Med. Chem. 16, 8697, (2008)

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Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition. Simone C B Gnoatto et al Eur. J. Med. Chem. 43, 1865-77, (2008)

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Purity-activity relationships of natural products: the case of anti-TB active ursolic acid. Birgit U Jaki et al J. Nat. Prod. 71, 1742-8, (2008)

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Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B. Phuong Thien Thuong et al J. Nat. Prod. 71, 1775-8, (2008)

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Antiproliferative triterpenes from Melaleuca ericifolia. Fatma M Abdel Bar et al J. Nat. Prod. 71, 1787-90, (2008)

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Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,). George R Pettit et al J. Nat. Prod. 71, 438-44, (2008)

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Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum. Changon Seo et al Bioorg. Med. Chem. Lett. 19, 2801-3, (2009)

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Synthesis and in vitro biological activity of retinyl polyhydroxybenzoates, novel hybrid retinoid derivatives. Sungbum Kim et al Bioorg. Med. Chem. Lett. 19, 508-12, (2009)

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Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B. Goo Yoon et al Bioorg. Med. Chem. Lett. 19, 5155-7, (2009)

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Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells. Do Thi Ha et al Bioorg. Med. Chem. Lett. 19, 5556-9, (2009)

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Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060. Changon Seo et al Bioorg. Med. Chem. Lett. 19, 6095-7, (2009)

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Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Phi Hung Nguyen et al Bioorg. Med. Chem. Lett. 19, 6745-9, (2009)

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Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis. Duc Manh Hoang et al Bioorg. Med. Chem. Lett. 19, 6759-61, (2009)

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Discovery of novel Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase inhibitors. Renato F Freitas et al Bioorg. Med. Chem. 17, 2476-82, (2009)

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Novel 3alpha-methoxyserrat-14-en-21beta-ol (PJ-1) and 3beta-methoxyserrat-14-en-21beta-ol (PJ-2)-curcumin, kojic acid, quercetin, and baicalein conjugates as HIV agents. Reiko Tanaka et al Bioorg. Med. Chem. 17, 5238-46, (2009)

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Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species. Huang-Yao Tu et al Bioorg. Med. Chem. 17, 7265-74, (2009)

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The synthesis of ursolic acid derivatives with cytotoxic activity and the investigation of their preliminary mechanism of action. Yan-Qiu Meng et al Bioorg. Med. Chem. 17, 848-54, (2009)

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Cytotoxic triterpenoids from the stems of Microtropis japonica. I-Hsiao Chen et al J. Nat. Prod. 72, 1231-6, (2009)

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Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. Pu Zhang et al J. Nat. Prod. 72, 1414-8, (2009)

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Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. Jing Li et al J. Nat. Prod. 72, 983-7, (2009)

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Structure-Activity Relationship Study of Betulinic Acid, A Novel and Selective TGR5 Agonist, and Its Synthetic Derivatives: Potential Impact in Diabetes. Genet, C., et al J. Med. Chem. 53, 178-190, (2010)

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In vitro antituberculosis activities of the constituents isolated from Haloxylon salicornicum. Nazia Bibi et al Bioorg. Med. Chem. Lett. 20, 4173-6, (2010)

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Apoptotic action of ursolic acid isolated from Corni fructus in RC-58T/h/SA#4 primary human prostate cancer cells. Seong-Hyuk Kwon et al Bioorg. Med. Chem. Lett. 20, 6435-8, (2010)

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Ixorapeptide I and ixorapeptide II, bioactive peptides isolated from Ixora coccinea. Chia-Lin Lee et al Bioorg. Med. Chem. Lett. 20, 7354-7, (2010)

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11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches. Judith M Rollinger et al Bioorg. Med. Chem. 18, 1507-15, (2010)

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Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Francisco J Prado-Prado et al Bioorg. Med. Chem. 18, 2225-31, (2010)

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An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds. Yunbao Liu et al J. Nat. Prod. 73, 1193-5, (2010)

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Cytotoxic and NF-kappaB inhibitory constituents of Artocarpus rigida. Yulin Ren et al J. Nat. Prod. 73, 949-55, (2010)

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Design, synthesis, and evaluation of bromo-retrochalcone derivatives as protein tyrosine phosphatase 1B inhibitors. Zhiguo Liu et al Bioorg. Med. Chem. Lett. 21, 3755-8, (2011)

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Ursolic acid is a PPAR-? agonist that regulates hepatic lipid metabolism. Yaoyao Jia et al Bioorg. Med. Chem. Lett. 21, 5876-80, (2011)

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New 5-deoxyflavonoids and their inhibitory effects on protein tyrosine phosphatase 1B (PTP1B) activity. Phi Hung Nguyen et al Bioorg. Med. Chem. 19, 3378-83, (2011)

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Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies. Zhongjie Liang et al Eur. J. Med. Chem. 46, 2011-21, (2011)

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In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives J. Shao, et al., Eur. J. Med. Chem. 46, 2652-2661, (2011)

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Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors. Liang-Peng Sun et al Eur. J. Med. Chem. 46, 3630-8, (2011)

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Antituberculosis cycloartane triterpenoids from Radermachera boniana. Ngan B Truong et al J. Nat. Prod. 74, 1318-22, (2011)

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Triterpenoid saponins from Symplocos lancifolia. Ivone Lucia Acebey-Castellon et al J. Nat. Prod. 74, 163-8, (2011)

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Triggering of erythrocyte cell membrane scrambling by ursolic acid. Kashif Jilani et al J. Nat. Prod. 74, 2181-6, (2011)

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Antiproliferative triterpenes from the leaves and twigs of Juglans sinensis on HSC-T6 cells. Heejung Yang et al J. Nat. Prod. 74, 751-6, (2011)

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Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages. Ji Sang Hwang et al Bioorg. Med. Chem. Lett. 22, 706-8, (2012)

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A high-content drug screen identifies ursolic acid as an inhibitor of amyloid-β interactions with its receptor CD36. Wilkinson, K. et al. J. Biochem. 286, 34914-34922, (2011)

Merck 14,9890

Beil. 10,II,202

FT-IR 2 (3), 4240:D / FT-NMR 1 (3), 595:A / RegBook 1 (2), 2869:C / Structure Index 1, 459:C:6