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89871 Fluka

Toluene 2,4-diisocyanate

technical, ≥90% (GC)

Synonym: 2,4-Diisocyanatotoluene, 4-Methyl-m-phenylene diisocyanate, Tolylene 2,4-diisocyanate

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Properties

grade   technical
assay   ≥90% (GC)
refractive index   n20/D 1.567
bp   124-126 °C/18 mmHg(lit.)
  251 °C(lit.)
mp   19.5-21.5 °C(lit.)
density   1.22 g/mL at 20 °C(lit.)

Description

Caution

may become turbid on storage

Price and Availability

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analytical standard

Toluene 2,4-diisocyanate

purum, for electron microscopy, ≥98.0% (GC)

Tolylene-<WBR>2,4-<WBR>diisocyanate

technical grade, 80%

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
RIDADR 
UN 2078 6.1 / PGII
WGK Germany 
2
RTECS 
CZ6300000
Flash Point(F) 
269.6 °F
Flash Point(C) 
132 °C

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

Neutrophil and eosinophil granulocytes as key players in a mouse model of chemical-induced asthma. De Vooght V, Smulders S, Haenen S, et al. Toxicol. Sci. 131(2), 406-18, (2013)

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The cardiac protein αT-catenin contributes to chemical-induced asthma. Folmsbee SS, Morales-Nebreda L, Van Hengel J, et al. Am. J. Physiol. Lung Cell. Mol. Physiol. 308(3), L253-8, (2015)

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Serum specific IgG response to toluene diisocyanate-tissue transglutaminase conjugate in toluene diisocyanate-induced occupational asthmatics. Pham le D, Kim MA, Yoon MG, et al. Ann. Allergy Asthma Immunol. 113(1), 48-54, (2014)

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Toluene diisocyanates. Rep. Carcinog. 12, 414-6, (2011)

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Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. Pier Giovanni Baraldi et al J. Med. Chem. 53, 5085-107, (2010)

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Air exposure assessment of TDI and biological monitoring of TDA in urine in workers in polyurethane foam industry. Geens T, Dugardin S, Schockaert A, et al. Occup. Environ. Med. 69(2), 93-8, (2012)

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Live monitoring of cargo release from peptide-based hybrid nanocapsules induced by enzyme cleavage. Andrieu J, Kotman N, Maier M, et al. Macromol. Rapid Commun. 33(3), 248-53, (2012)

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Occupational contact allergy to monomeric isocyanates. Aalto-Korte K, Suuronen K, Kuuliala O, et al. Contact Dermatitis 67(2), 78-88, (2012)

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Proteome changes in auricular lymph nodes and serum after dermal sensitization to toluene diisocyanate in mice. Haenen S, Clynen E, De Vooght V, et al. Proteomics 12(23-24), 3548-58, (2012)

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Participation of complement 3a receptor (C3aR) in the sensitization phase of Th2 mediated allergic contact dermatitis. Niebuhr M, Bäumer W, Kietzmann M, et al. Exp. Dermatol. 21, 52-56, (2012)

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Toluene diisocyanate reactivity with glutathione across a vapor/liquid interface and subsequent transcarbamoylation of human albumin. Wisnewski AV, Hettick JM, and Siegel PD Chem. Res. Toxicol. 24(10), 1686-93, (2011)

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Does diisocyanate exposure result in neurotoxicity? Hughes MA, Carson M, Collins MA, et al. Clin. Toxicol. (Phila.) 52(4), 242-57, (2014)

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Mechanism of E-cadherin redistribution in bronchial airway epithelial cells in a TDI-induced asthma model. Song J, Zhao H, Dong H, et al. Toxicol. Lett. 220(1), 8-14, (2013)

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A method for determining reactive hydroxyl groups in natural fibers: application to ramie fiber and its modification. He L, Li X, Li W, et al. Carbohydr. Res. 348, 95-8, (2012)

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Cells and mediators in diisocyanate-induced occupational asthma. Shin YS, Kim MA, Pham LD, et al. Curr. Opin. Allergy Clin. Immunol. 13(2), 125-31, (2013)

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Determination of isocyanate specific albumin-adducts in workers exposed to toluene diisocyanates. Sabbioni G, Gu Q, Vanimireddy LR. Biomarkers 17, 150-159, (2012)

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Transcriptional microarray analysis reveals suppression of histamine signaling by Kujin alleviates allergic symptoms through down-regulation of FAT10 expression. Dev S, Mizuguchi H, Das AK, et al. Int. Immunopharmacol. 11(10), 1504-9, (2011)

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Risk assessment for consumer exposure to toluene diisocyanate (TDI) derived from polyurethane flexible foam. Arnold SM, Collins MA, Graham C, et al. Regul Toxicol Pharmacol 64(3), 504-15, (2012)

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Role of vitamin D-binding protein in isocyanate-induced occupational asthma. Kim SH, Choi GS, Nam YH, et al. Exp. Mol. Med. 44, 319-329, (2012)

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Occupational exposure to toluene diisocyanate and neutrophilic bronchitis without asthma. Pala G, Pignatti P, and Moscato G Clin. Toxicol. (Phila.) 49(6), 506-7, (2011)

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AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma. Park SJ, Lee KS, Kim SR, et al. Inflamm. Res. 61(10), 1069-83, (2012)

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Development of a respiratory sensitization/elicitation protocol of toluene diisocyanate (TDI) in Brown Norway rats to derive an elicitation-based occupational exposure level. Pauluhn J Toxicology 319, 10-22, (2014)

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Quercetin inhibits transcriptional up-regulation of histamine H1 receptor via suppressing protein kinase C-δ/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells. Hattori M, Mizuguchi H, Baba Y, et al. Int. Immunopharmacol. 15(2), 232-9, (2013)

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Assessment of exposure to TDI and MDI during polyurethane foam production in Poland using integrated theoretical and experimental data. Kupczewska-Dobecka M, Czerczak S, and Brzeźnicki S Environ. Toxicol. Pharmacol. 34(2), 512-8, (2012)

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Vapor conjugation of toluene diisocyanate to specific lysines of human albumin. Hettick JM, Siegel PD, Green BJ, et al. Anal. Biochem. 421(2), 706-11, (2012)

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Albizia lebbeck suppresses histamine signaling by the inhibition of histamine H1 receptor and histidine decarboxylase gene transcriptions. Nurul IM, Mizuguchi H, Shahriar M, et al. Int. Immunopharmacol. 11(11), 1766-72, (2011)

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Production, characterization and utility of a panel of monoclonal antibodies for the detection of toluene diisocyanate haptenated proteins. Ruwona TB, Johnson VJ, Hettick JM, et al. J. Immunol. Methods 373(1-2), 127-35, (2011)

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Development of sandwich ELISAs for the detection of aromatic diisocyanate adducts. Lemons AR, Bledsoe TA, Siegel PD, et al. J. Immunol. Methods 397(1-2), 66-70, (2013)

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Biological monitoring as a valid tool to assess occupational exposure to mixtures of 2,4-:2,6-toluene diisocyanate. De Palma G, Cortesi I, Ghitti R, et al. Med. Lav. 103(5), 361-71, (2012)

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[Pathogenetic and clinical aspects of diisocyanate asthma]. Swierczyńska-Machura D and Pałczyński C Med. Pr. 63(1), 97-103, (2012)

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Effects of lactoferrin on elicitation of the antigen-specific cellular and humoral cutaneous response in mice. Zimecki M, Artym J, Kocięba M, et al. Postepy Hig. Med. Dosw. (Online) 66, 16-22, (2012)

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Genetic variants in antioxidant genes are associated with diisocyanate-induced asthma. Yucesoy, B., et al. Toxicol. Sci. 129(1), 166-73, (2012)

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Merck 14,9530

Beil. 13,IV,243

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