|Related Categories||A - D, Alphabetical, Analytical Standards, Analytical/Chromatography, Betula,|
|shelf life||(limited shelf life, expiry date on the label)|
|mp||295-298 °C (dec.)(lit.)|
Betulinic acid, a pentacyclic triterpene, selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism.
Bottomless glass bottle. Contents are inside inserted fused cone.
Two series of new semisynthetic triterpene derivatives: differences in anti-malarial activity, cytotoxicity and mechanism of action. da Silva GN, Maria NR, Schuck DC, et al. Malaria Journal 12, 89, (2013)
Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK-mTOR-SREBP signaling pathway. Quan HY, Kim do Y, Kim SJ, et al. Biochem. Pharmacol. 85(9), 1330-40, (2013)
Betulinic acid selectively increases protein degradation and enhances prostate cancer-specific apoptosis: possible role for inhibition of deubiquitinase activity. Reiner T, Parrondo R, de Las Pozas A, et al. PLoS ONE 8(2), e56234, (2013)
Apoptosis of human breast cancer cells induced by microencapsulated betulinic acid from sour jujube fruits through the mitochondria transduction pathway. Sun YF, Song CK, Viernstein H, et al. Food Chem. 138(2-3), 1998-2007, (2013)
Anti-inflammatory, antimicrobial and antioxidant activities of Diospyros bipindensis (Gürke) extracts and its main constituents. Cesari I, Hoerlé M, Simoes-Pires C, et al. J. Ethnopharmacol. 146(1), 264-70, (2013)
A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients. Caligiani A, Malavasi G, Palla G, et al. Food Chem. 136(2), 735-41, (2013)
Combined treatment of betulinic acid, a PTP1B inhibitor, with Orthosiphon stamineus extract decreases body weight in high-fat-fed mice. Choi YJ, Park SY, Kim JY, et al. J. Med. Food 16(1), 2-8, (2013)
GDC-0941 enhances the lysosomal compartment via TFEB and primes glioblastoma cells to lysosomal membrane permeabilization and cell death. Enzenmüller S, Gonzalez P, Karpel-Massler G, et al. Cancer Lett. 329(1), 27-36, (2013)
Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum. Inoue T, Wang JH, Higashiyama M, et al. Am. J. Physiol. Gastrointest. Liver Physiol. 303(7), G810-6, (2012)
FT-IR 2 (3), 4240:C / FT-NMR 1 (3), 594:C / IR-Spectra (2), 1282:D / IR-Spectra (3), 1499:H / NMR-Reference 2 (2), 929:B / RegBook 1 (2), 2869:B / Structure Index 1, 459:B:6
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