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|Gene Information||rat ... Ednra(24326)|
Sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase.
Mode of Action: Inhibits folic acid synthesis in prokaryotes.
Anti-microbial Spectrum: Gram positive, Gram negative, Chlamydia
Mode of Resistance: Alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P261-P280-P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Faceshields, Gloves|
|Hazard Codes (Europe)||Xi|
|Risk Statements (Europe)||36/37/38-43|
|Safety Statements (Europe)||26-36|
Synthesis and biological study of medicinally important Mannich bases derived from 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a pentahydroxy naphthacene carboxamide. Sheela Joshi et al Bioorg. Med. Chem. Lett. 17, 645-8, (2007)
Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae. Ying-Tsong Chen et al Antimicrob. Agents Chemother. 51, 3004-7, (2007)
Synthesis, in vitro antibacterial and carbonic anhydrase II inhibitory activities of N-acylsulfonamides using silica sulfuric acid as an efficient catalyst under both solvent-free and heterogeneous conditions. Ahmad Reza Massah et al Bioorg. Med. Chem. 16, 5465-72, (2008)
High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. Hong Yang et al Antimicrob. Agents Chemother. 52, 4268-73, (2008)
Replication of Colonic Crohn's Disease Mucosal Escherichia coli Isolates within Macrophages and Their Susceptibility to Antibiotics. Sreedhar Subramanian et al Antimicrob. Agents Chemother. 52, 427-34, (2008)
Synthesis and antibacterial activity of some novel bis-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and bis-4-thiazolidinone derivatives from terephthalic dihydrazide. Vikrant S Palekar et al Eur. J. Med. Chem. 44, 5112-6, (2009)
Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. Neil Woodford et al Antimicrob. Agents Chemother. 53, 4472-82, (2009)
High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. Junying Ma et al Antimicrob. Agents Chemother. 53, 519-24, (2009)
Transfer of plasmid-mediated CTX-M-9 from Salmonella enterica serotype Virchow to Enterobacteriaceae in human flora-associated rats treated with cefixime. S Faure et al Antimicrob. Agents Chemother. 54, 164-9, (2010)
KPC-producing extreme drug-resistant Klebsiella pneumoniae isolate from a patient with diabetes mellitus and chronic renal failure on hemodialysis in South Korea. Ji-Young Rhee et al Antimicrob. Agents Chemother. 54, 2278-9, (2010)
Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. Hwang-Soo Joo et al Antimicrob. Agents Chemother. 54, 4942-4, (2010)
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