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|Gene Information||rat ... Ednra(24326)|
Sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase.
Mode of Action: Inhibits folic acid synthesis in prokaryotes.
Anti-microbial Spectrum: Gram positive, Gram negative, Chlamydia
Mode of Resistance: Alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P261-P280-P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Faceshields, Gloves|
|Hazard Codes (Europe)||Xi|
|Risk Statements (Europe)||36/37/38-43|
|Safety Statements (Europe)||26-36|
Clinical manifestations, laboratory findings, and therapeutic regimen in hospitalized children with brucellosis in an Iranian Referral Children Medical Centre. Fanni F, Shahbaznejad L, Pourakbari B, et al. J. Health. Popul. Nutr. 31(2), 218-22, (2013)
Sub-inhibitory concentrations of antibiotics and wastewater influencing biofilm formation and gene expression of multi-resistant Pseudomonas aeruginosa wastewater isolates. Bruchmann J, Kirchen S, and Schwartz T Environ. Sci. Pollut. Res. Int. 20(6), 3539-49, (2013)
Forward chemical genetic screens in Arabidopsis identify genes that influence sensitivity to the phytotoxic compound sulfamethoxazole. Schreiber KJ, Austin RS, Gong Y, et al. BMC Plant Biol. 12, 226, (2012)
Toxic effects of erythromycin, ciprofloxacin and sulfamethoxazole exposure to the antioxidant system in Pseudokirchneriella subcapitata. Nie XP, Liu BY, Yu HJ, et al. Environ. Pollut. 172, 23-32, (2013)
Comparative study of class 1 integron, ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, tetracycline (ACSSuT) and fluoroquinolone resistance in various Salmonella serovars from humans and animals. Hsu YM, Tang CY, Lin H, et al. Comp. Immunol. Microbiol. Infect. Dis. 36(1), 9-16, (2013)
Substituent effect on the electron acceptor property of 1,4-benzoquinone towards the formation of molecular complex with sulfamethoxazole. Ganesh K, Satheshkumar A, Balraj C, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 107, 156-66, (2013)
Identification and typing of Salmonella enterica serotypes isolated from guinea fowl (Numida meleagris) farms in Benin during four laying seasons (2007 to 2010). Boko CK, Kpodekon TM, Duprez JN, et al. Avian Pathol. 42(1), 1-8, (2013)
Optimized removal of dissolved organic carbon and trace organic contaminants during combined ozonation and artificial groundwater recharge. Hübner U, Miehe U, and Jekel M Water Res. 46(18), 6059-68, (2012)
Catalytic ozonation of sulphamethoxazole in the presence of carbon materials: catalytic performance and reaction pathways. Gonçalves AG, Órfão JJ, and Pereira MF J. Hazard. Mater. 239-240, 167-74, (2012)
Synthesis and biological study of medicinally important Mannich bases derived from 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a pentahydroxy naphthacene carboxamide. Sheela Joshi et al Bioorg. Med. Chem. Lett. 17, 645-8, (2007)
Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae. Ying-Tsong Chen et al Antimicrob. Agents Chemother. 51, 3004-7, (2007)
Synthesis, in vitro antibacterial and carbonic anhydrase II inhibitory activities of N-acylsulfonamides using silica sulfuric acid as an efficient catalyst under both solvent-free and heterogeneous conditions. Ahmad Reza Massah et al Bioorg. Med. Chem. 16, 5465-72, (2008)
High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. Hong Yang et al Antimicrob. Agents Chemother. 52, 4268-73, (2008)
Replication of Colonic Crohn's Disease Mucosal Escherichia coli Isolates within Macrophages and Their Susceptibility to Antibiotics. Sreedhar Subramanian et al Antimicrob. Agents Chemother. 52, 427-34, (2008)
Synthesis and antibacterial activity of some novel bis-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and bis-4-thiazolidinone derivatives from terephthalic dihydrazide. Vikrant S Palekar et al Eur. J. Med. Chem. 44, 5112-6, (2009)
Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. Neil Woodford et al Antimicrob. Agents Chemother. 53, 4472-82, (2009)
High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. Junying Ma et al Antimicrob. Agents Chemother. 53, 519-24, (2009)
Transfer of plasmid-mediated CTX-M-9 from Salmonella enterica serotype Virchow to Enterobacteriaceae in human flora-associated rats treated with cefixime. S Faure et al Antimicrob. Agents Chemother. 54, 164-9, (2010)
KPC-producing extreme drug-resistant Klebsiella pneumoniae isolate from a patient with diabetes mellitus and chronic renal failure on hemodialysis in South Korea. Ji-Young Rhee et al Antimicrob. Agents Chemother. 54, 2278-9, (2010)
Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. Hwang-Soo Joo et al Antimicrob. Agents Chemother. 54, 4942-4, (2010)
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