Sulfamethoxazole

Papers

Mechanisms of resistance to trimethoprim, the sulfonamides, and trimethoprim-sulfamethoxazole. Then, R.L. Rev. Infect. Dis. 4, 261-269, (1982)

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Sulfonamide resistance: mechanisms and trends. Skold, O. Drug Resist. Updat. 3, 155-160, (2000)

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T-lineage cells require the thymus but not VDJ recombination to produce IL-17A and regulate granulopoiesis in vivo. Emily Smith et al J. Immunol. 183, 5685-93, (2010)

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Synthesis and in vitro study of novel Mannich bases as antibacterial agents. Sheela Joshi et al Bioorg. Med. Chem. Lett. 15, 221-6, (2005)

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QSAR study on the antibacterial activity of some sulfa drugs: building blockers of Mannich bases. Dheeraj Mandloi et al Bioorg. Med. Chem. Lett. 15, 405-11, (2005)

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Use of simple docking methods to screen a virtual library for heteroactivators of cytochrome P450 2C9. Charles W Locuson et al J. Med. Chem. 50, 1158-65, (2007)

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Synthesis and biological study of medicinally important Mannich bases derived from 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a pentahydroxy naphthacene carboxamide. Sheela Joshi et al Bioorg. Med. Chem. Lett. 17, 645-8, (2007)

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Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae. Ying-Tsong Chen et al Antimicrob. Agents Chemother. 51, 3004-7, (2007)

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Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1. Xiaogang Xu et al Antimicrob. Agents Chemother. 51, 4105-10, (2007)

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In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. Kristi L Frank et al Antimicrob. Agents Chemother. 51, 888-95, (2007)

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

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Synthesis, in vitro antibacterial and carbonic anhydrase II inhibitory activities of N-acylsulfonamides using silica sulfuric acid as an efficient catalyst under both solvent-free and heterogeneous conditions. Ahmad Reza Massah et al Bioorg. Med. Chem. 16, 5465-72, (2008)

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Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors. Bryan Knuckley et al Bioorg. Med. Chem. 16, 739-45, (2008)

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Computational aqueous solubility prediction for drug-like compounds in congeneric series. Lei Du-Cuny et al Eur. J. Med. Chem. 43, 501-12, (2008)

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Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. Vincent Cattoir et al Antimicrob. Agents Chemother. 52, 3801-4, (2008)

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High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. Hong Yang et al Antimicrob. Agents Chemother. 52, 4268-73, (2008)

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Replication of Colonic Crohn's Disease Mucosal Escherichia coli Isolates within Macrophages and Their Susceptibility to Antibiotics. Sreedhar Subramanian et al Antimicrob. Agents Chemother. 52, 427-34, (2008)

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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. R Scott Obach et al Drug Metab. Dispos. 36, 1385-405, (2008)

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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Naomi L Kruhlak et al Toxic. Mech. Methods 18, 217-27, (2008)

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Physicochemical determinants of human renal clearance. Manthena V S Varma et al J. Med. Chem. 52, 4844-52, (2009)

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Synthesis and antibacterial activity of some novel bis-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and bis-4-thiazolidinone derivatives from terephthalic dihydrazide. Vikrant S Palekar et al Eur. J. Med. Chem. 44, 5112-6, (2009)

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New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis. Minghua Wang et al Antimicrob. Agents Chemother. 53, 1892-7, (2009)

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Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. Alvaro San Millan et al Antimicrob. Agents Chemother. 53, 3399-404, (2009)

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Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. Neil Woodford et al Antimicrob. Agents Chemother. 53, 4472-82, (2009)

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High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. Junying Ma et al Antimicrob. Agents Chemother. 53, 519-24, (2009)

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IncA/C plasmid-mediated florfenicol resistance in the catfish pathogen Edwardsiella ictaluri. Timothy J Welch et al Antimicrob. Agents Chemother. 53, 845-6, (2009)

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Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting. Ranjana Pathania et al Nat. Chem. Biol. 5, 849-56, (2009)

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Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Manthena V S Varma et al J. Med. Chem. 53, 1098-108, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Transfer of plasmid-mediated CTX-M-9 from Salmonella enterica serotype Virchow to Enterobacteriaceae in human flora-associated rats treated with cefixime. S Faure et al Antimicrob. Agents Chemother. 54, 164-9, (2010)

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KPC-producing extreme drug-resistant Klebsiella pneumoniae isolate from a patient with diabetes mellitus and chronic renal failure on hemodialysis in South Korea. Ji-Young Rhee et al Antimicrob. Agents Chemother. 54, 2278-9, (2010)

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Different classes of antibiotics differentially influence shiga toxin production. Colleen Marie McGannon et al Antimicrob. Agents Chemother. 54, 3790-8, (2010)

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Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. Hwang-Soo Joo et al Antimicrob. Agents Chemother. 54, 4942-4, (2010)

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FDA-approved drug labeling for the study of drug-induced liver injury. Minjun Chen et al Drug Discov. Today 16, 697-703, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Antimicrobial activity of sulfonamides containing 5-chloro-2-hydroxybenzaldehyde and 5-chloro-2-hydroxybenzoic acid scaffold. Martin Krátký et al Eur. J. Med. Chem. 50, 433-40, (2012)

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Merck 14,8918