|Related Categories||Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Application Index, Bioactive Small Molecules,|
human ... ALB(213), CYP1A2(1544), CYP2C9(1559), EPHX2(2053), KCNJ1(3758)|
mouse ... Ephx2(13850)
Anti-diabetic agent. Metabolized by CYP2C9 (tolbutamide hydroxylase).
25, 100, 500 g in glass bottle
Certificate of Analysis
Certificate of Origin
Potassium channels are essential in both excitable and non-excitable cells for the control of membrane potential, regulation of cell volume, and the secretion of salt, neurotransmitters and hormones....
Keywords: Absorption, Cancer, Cell proliferation, Cell signaling, Diabetes, Diseases, Hormones, Ligands, Neurotransmitters, Phosphorylations, Sequencing
Calcium Influx Into MIN6 Insulinoma Cells Induces Expression Of Egr-1 Involving Extracellular Signal-regulated Protein Kinase And The Transcription Factors Elk-1 And CREB. Mayer, S.I., and Thiel, G. Eur. J. Cell Biol. 88, 19-33, (2009)
Development and validation of a simple LC method for the determination of phenacetin, coumarin, tolbutamide, chlorzoxazone, testosterone and their metabolites as markers of cytochromes 1A2, 2A6, 2C11, 2E1 and 3A2 in rat microsomal medium. Zhai X and Lu Y Pharmazie 68(1), 19-26, (2013)
Evaluation of the pharmacokinetic interaction between ticagrelor and tolbutamide, a cytochrome P450 2C9 substrate, in healthy volunteers. Teng R, Mitchell P, and Butler K Int. J. Clin. Pharmacol. Ther. 51(4), 305-12, (2013)
Phase 1 and phase 2 drug metabolism and bile acid production of HepaRG cells in a bioartificial liver in absence of dimethyl sulfoxide. Hoekstra R, Nibourg GA, van der Hoeven TV, et al. Drug Metab. Dispos. 41(3), 562-7, (2013)
Influences of processed rhubarbs on the activities of four CYP isozymes and the metabolism of saxagliptin in rats based on probe cocktail and pharmacokinetics approaches. Gao J, Shi Z, Zhu S, et al. J. Ethnopharmacol. 145(2), 566-72, (2013)
Activation of glibenclamide-sensitive ATP-sensitive K+ channels during β-adrenergically induced metabolic stress produces a substrate for atrial tachyarrhythmia. Kim SJ, Zhang H, Khaliulin I, et al. Circ. Arrhythm. Electrophysiol. 5(6), 1184-92, (2012)
Potentiation of sulfonylurea action by an EPAC-selective cAMP analog in INS-1 cells: comparison of tolbutamide and gliclazide and a potential role for EPAC activation of a 2-APB-sensitive Ca2+ influx. Jarrard RE, Wang Y, Salyer AE, et al. Mol. Pharmacol. 83(1), 191-205, (2013)
Synthesis, antidiabetic and hypolipidemic activities of new diethylamine and triethoxysilyl derivatives of tolbutamide on rats. Ahmadi A, Khalili M, Seyedhoseyni S, et al. Med. Chem. 8(5), 964-9, (2012)
Tolbutamide controls glucagon release from mouse islets differently than glucose: involvement of K(ATP) channels from both α-cells and δ-cells. Cheng-Xue R, Gómez-Ruiz A, Antoine N, et al. Diabetes 62(5), 1612-22, (2013)
Enzyme kinetic and molecular docking studies on the metabolic interactions of 1-hydroxy-2,3,5-trimethoxy-xanthone, isolated from Halenia elliptica D. Don, with model probe substrates of human cytochrome P450 enzymes. Feng R, Zhou X, Or PM, et al. Phytomedicine 19(12), 1125-33, (2012)
UPLC-MS-MS method for simultaneous determination of caffeine, tolbutamide, metoprolol, and dapsone in rat plasma and its application to cytochrome P450 activity study in rats. Liu Y, Li X, Yang C, et al. J. Chromatogr. Sci. 51(1), 26-32, (2013)
Design, synthesis, and biological evaluation of substituted-N-(thieno[2,3-b]pyridin-3-yl)-guanidines, N-(1H-pyrrolo[2,3-b]pyridin-3-yl)-guanidines, and N-(1H-indol-3-yl)-guanidines. Rajesh H Bahekar et al Bioorg. Med. Chem. 15, 3248-65, (2007)
Structures of steroidal alkaloid oligoglycosides, robeneosides A and B, and antidiabetogenic constituents from the Brazilian medicinal plant Solanum lycocarpum. Masayuki Yoshikawa et al J. Nat. Prod. 70, 210-4, (2007)
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. Michael H Abraham et al Eur. J. Med. Chem. 43, 478-85, (2008)
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)
Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1). Valentina L Kouznetsova et al Bioorg. Med. Chem. 19, 3320-40, (2011)
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