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Beclomethasone dipropionate

anhydrous, European Pharmacopoeia (EP) Reference Standard

Synonym: 9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate

  • CAS Number 5534-09-8

  • Empirical Formula (Hill Notation) C28H37ClO7

  • Molecular Weight 521.04

  •  MDL number MFCD00135613

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, EP Standards, EP Standards A - B, Pharmacopeia & Metrological Institutes Standards More...
form   neat
quality   anhydrous
format   neat

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

Unit quantity: 150 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference subtance catalogue.

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Beclometasone dipropionate for peak identification

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analytical standard, for drug analysis

Beclomethasone dipropionate

United States Pharmacopeia (USP) Reference Standard

Safety & Documentation

Safety Information

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Documents

Certificate of Analysis

Protocols & Articles

Peer-Reviewed Papers

References

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Beclomethasone dipropionate in the management of rhinitis--a review. Small P, Black M, Frenkiel S, et al. Ann. Allergy 49(3), 127-30, (1982)

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Effect of changing the fine particle mass of inhaled beclomethasone dipropionate on intrapulmonary deposition and pharmacokinetics. Seale JP and Harrison LI Respir. Med. 92 Suppl A, 9-15, (1998)

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Inhaled corticosteroid and long-acting β2-agonist pharmacological profiles: effective asthma therapy in practice. Tamm M, Richards DH, Beghé B, et al. Respir. Med. 106 Suppl 1, S9-19, (2012)

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[A comparison of the pharmacological actions between DSCG (disodium cromoglycate) and BDP (beclomethasone dipropionate) in the treatment of bronchial asthma]. Shida T Nihon Rinsho. 54(11), 3011-6, (1996)

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In brief: two intranasal corticosteroid HFA aerosols for allergic rhinitis. Med. Lett. Drugs Ther. 54(1401), 84, (2012)

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[Therapy of bronchial asthma: MART concept: maintenance and acute therapy with extra fine particles]. MMW Fortschr. Med. 154(17), 70-1, (2012)

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[Local antibacterial therapy for the inflammatory diseases of the external and middle ear]. Khon EM, Dzhenzhera GE, and Ovchinnikov AIu Vestn. Otorinolaringol. (3), 92-4, (2012)

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Oral beclomethasone dipropionate: a critical review of its use in the management of ulcerative colitis and Crohn's disease. Fascì Spurio F, Aratari A, Margagnoni G, et al. Curr. Clin. Pharmacol. 7(2), 131-6, (2012)

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High-dose inhaled beclomethasone dipropionate in the treatment of asthma. Lindroos H Rev. Ig. Bacteriol. Virusol. Parazitol. Epidemiol. Pneumoftiziol. Pneumoftiziol. 40(4), 27-9, (1991)

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Corticosteroids for the common cold. Hayward G, Thompson MJ, Perera R, et al. Cochrane Database Syst. Rev. 8, CD008116, (2012)

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The novel TLR-9 agonist QbG10 shows clinical efficacy in persistent allergic asthma. Beeh KM, Kanniess F, Wagner F, et al. J. Allergy Clin. Immunol. 131(3), 866-74, (2013)

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Beclomethasone dipropionate. A reappraisal of its pharmacodynamic properties and therapeutic efficacy after a decade of use in asthma and rhinitis. Brogden RN, Heel RC, Speight TM, et al. Drugs 28(2), 99-126, (1984)

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Asthma outcomes and costs of therapy with extrafine beclomethasone and fluticasone. Colice G, Martin RJ, Israel E, et al. J. Allergy Clin. Immunol. 132(1), 45-54, (2013)

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Air-jet and vibrating-mesh nebulization of niosomes generated using a particulate-based proniosome technology. Elhissi A, Hidayat K, Phoenix DA, et al. Int. J. Pharm. 444(1-2), 193-9, (2013)

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A comparison of beclomethasone dipropionate and budesonide in the treatment of asthma. Davies B Br. J. Clin. Pract. 47(2), 87-93, (1993)

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Safety and efficacy of once-daily treatment with beclomethasone dipropionate nasal aerosol in subjects with perennial allergic rhinitis. Meltzer EO, Jacobs RL, LaForce CF, et al. Allergy Asthma Proc. 33(3), 249-57, (2012)

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Step-down from high dose fixed combination therapy in asthma patients: a randomized controlled trial. Papi A, Nicolini G, Crimi N, et al. Respir. Res. 13, 54, (2012)

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Inhaled corticosteroids increase the risk of oropharyngeal colonization by Streptococcus pneumoniae in children with asthma. Zhang L, Prietsch SO, Mendes AP, et al. Respirology 18(2), 272-7, (2013)

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Oral locally active steroids in inflammatory bowel disease. Nunes T, Barreiro-de Acosta M, Marin-Jiménez I, et al. J. Crohns. Colitis 7(3), 183-91, (2013)

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Metabolism of beclomethasone dipropionate by cytochrome P450 3A enzymes. Roberts JK, Moore CD, Ward RM, et al. J. Pharmacol. Exp. Ther. 345(2), 308-16, (2013)

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Efficacy and safety of once-daily treatment with beclomethasone dipropionate nasal aerosol in subjects with seasonal allergic rhinitis. van Bavel JH, Ratner PH, Amar NJ, et al. Allergy Asthma Proc. 33(5), 386-96, (2012)

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Are we overlooking persistent small airways dysfunction in community-managed asthma? Anderson WJ, Zajda E, and Lipworth BJ Ann. Allergy Asthma Immunol. 109(3), 185-189.e2, (2012)

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Comparative physicochemical and pharmacokinetic profiles of inhaled beclomethasone dipropionate and budesonide. Boobis AR Respir. Med. 92 Suppl B, 2-6, (1998)

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Oral beclomethasone dipropionate: a topically active corticosteroid for the treatment of gastrointestinal graft-versus-host disease following allogeneic hematopoietic cell transplantation. McDonald GB Expert Opin. Investig. Drugs 16(10), 1709-24, (2007)

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Influence of low-dose ritonavir with and without darunavir on the pharmacokinetics and pharmacodynamics of inhaled beclomethasone. Boyd SD, Hadigan C, McManus M, et al. J. Acquir. Immune Defic. Syndr. 63(3), 355-61, (2013)

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Engineering drug ultrafine particles of beclomethasone dipropionate for dry powder inhalation. Xu LM, Zhang QX, Zhou Y, et al. Int. J. Pharm. 436(1-2), 1-9, (2012)

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Once-daily treatment with beclomethasone dipropionate nasal aerosol does not affect hypothalamic-pituitary-adrenal axis function. Ratner PH, Miller SD, Hampel FC, et al. Ann. Allergy Asthma Immunol. 109(5), 336-41, (2012)

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Effectiveness and safety of beclomethasone dipropionate, an intranasal corticosteroid, in the treatment of patients with allergic rhinitis. Edwards TB Clin. Ther. 17(6), 1032-41, (1995)

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Sensitivity of impulse oscillometry and spirometry in beta-blocker induced bronchoconstriction and beta-agonist bronchodilatation in asthma. Short PM, Williamson PA, and Lipworth BJ Ann. Allergy Asthma Immunol. 109(6), 412-5, (2012)

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Non-genomic action of beclomethasone dipropionate on bronchoconstriction caused by leukotriene C4 in precision cut lung slices in the horse. Fugazzola M, Barton AK, Niedorf F, et al. BMC Vet. Res. 8, 160, (2012)

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Review of the toxicology of beclomethasone dipropionate. Libretto SE Arch. Toxicol. 69(8), 509-25, (1995)

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Clinical review of once-daily beclomethasone dipropionate for seasonal allergic rhinitis. Chervinsky P Clin. Ther. 18(5), 790-6; discussion 789, (1996)

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Effect of inhaled beclomethasone dipropionate and budesonide on growth in children with asthma. Allen DB Respir. Med. 92 Suppl B, 37-45, (1998)

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Relief of methacholine-induced bronchospasm with extrafine beclomethasone dipropionate/formoterol in comparison with salbutamol in asthma. Singh D, Corradi M, Bindi E, et al. Pulm. Pharmacol. Ther. 25(5), 392-8, (2012)

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Effect of inhaled beclomethasone dipropionate and budesonide on adrenal function, skin changes and cataract formation. Dluhy RG Respir. Med. 92 Suppl B, 15-23, (1998)

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Efficacy of inhaled beclomethasone dipropionate and budesonide in the treatment of asthma. Webb DR Respir. Med. 92 Suppl B, 7-14, (1998)

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Comparative review of the effects of inhaled beclomethasone dipropionate and budesonide on bone. D'Souza M Respir. Med. 92 Suppl B, 24-36, (1998)

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Fluticasone versus HFA-beclomethasone dipropionate for chronic asthma in adults and children. Lasserson TJ, Cates CK, Jones AB, et al. Cochrane Database Syst. Rev. (2), CD005309, (2006)

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[Use of inhaled beclomethasone dipropionate in adult asthma]. Guérin JC and Pappo M Presse Med. 21(32), 1526-31, (1992)

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Fluticasone versus HFA-beclomethasone dipropionate for chronic asthma in adults and children. Lasserson TJ, Cates CJ, Jones AB, et al. Cochrane Database Syst. Rev. (4), CD005309, (2005)

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[Beclomethasone dipropionate, budesonide and flunisolide in the treatment of bronchial asthma (a review of the literature and the authors' own research)]. Kakhnovskiĭ IM and Solomatin AS Ter. Arkh. 67(3), 34-8, (1995)

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[Characteristics of the latent period of sensorimotor reactions in middle-aged and elderly outpatients with asthma during long-term treatment with inhaled glucocorticosteroids]. Gutnik BI, Zitz SV, and Maksimova AV Ter. Arkh. 84(8), 41-4, (2012)

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Yellowish face mask in a child: a local side-effect of inhaled corticosteroids? Baroni A, Piccolo V, and Russo T Indian J. Dermatol. Venereol. Leprol. 78(5), 666, (2012)

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A case of recurrent acute haemorrhagic cystitis associated with salbutamol and beclomethasone use in a paediatric patient. Radice S, Carnovale C, Antoniazzi S, et al. J. Paediatr. Child Health 48(7), 620-1, (2012)

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Salbutamol: how does it enter smooth muscle cells? Chiappori A, Folli C, Riccio AM, et al. Int. J. Immunopathol. Pharmacol. 25(2), 541-6, (2012)

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