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O1378 Fluka

Oxycodone hydrochloride

analytical standard

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Properties

Related Categories Additional Standards, Alkaloids, Analytical Standards, Analytical/Chromatography, Chemical Structure,
grade   analytical standard
form   neat
drug control   USDEA Schedule II; Home Office Schedule 2; stupéfiant; kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada
format   neat

Description

Biochem/physiol Actions

μ and κ opioid receptor agonist.

Price and Availability

Customers Also Viewed

(±)-Methadone hydrochloride

powder, ≥98% (TLC)

Oxycodone hydrochloride solution

1.0 mg/mL in methanol, analytical standard, for drug analysis

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
22
WGK Germany 
3
RTECS 
QD2470000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

The intrinsic antinociceptive effects of oxycodone appear to be κ-opioid receptor mediated. Ross, F.B., and Smith, M.T. Pain 73, 151-157, (1997)

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Synergy between μ opioid ligands: evidence for functional interactions among μ opioid receptor subtypes. Bolan, E.A., et al. J. Pharmacol. Exp. Ther. 303, 557-562, (2002)

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Pain in 1,000 women treated for breast cancer: a prospective study of pain sensitivity and postoperative pain. Kaunisto MA, Jokela R, Tallgren M, et al. Anesthesiology 119(6), 1410-21, (2013)

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Determinants of increased opioid-related mortality in the United States and Canada, 1990-2013: a systematic review. King NB, Fraser V, Boikos C, et al. Am. J. Public Health 104(8), e32-42, (2014)

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Effect of catechol-o-methyltransferase-gene (COMT) variants on experimental and acute postoperative pain in 1,000 women undergoing surgery for breast cancer. Kambur O, Kaunisto MA, Tikkanen E, et al. Anesthesiology 119(6), 1422-33, (2013)

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The pill hustle: risky pain management for a gunshot victim. Lee J Soc. Sci. Med. 99, 162-8, (2013)

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Trends in opioid analgesic abuse and mortality in the United States. Dart RC, Surratt HL, Cicero TJ, et al. N. Engl. J. Med. 372(3), 241-8, (2015)

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Spontaneous resolution of quadrilateral space syndrome: a case report. Gregory T, Sangha H, and Bleakney R Am. J. Phys. Med. Rehabil. 94(1), e1-5, (2015)

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Single periarticular local infiltration analgesia reduces opiate consumption until 48 hours after total knee arthroplasty. A randomized placebo-controlled trial involving 56 patients. Niemeläinen M, Kalliovalkama J, Aho AJ, et al. Acta Orthop. 85(6), 614-9, (2014)

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Rational prescribing. Meyer CR Minn. Med. 96(3), 4, (2013)

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Rationale and design of the Oxycodone Users Registry: a prospective, multicenter registry of patients with nonmalignant pain. Kim M, Chow W, and Benson C J. Opioid Manag. 9(3), 189-204, (2013)

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Oxycodone: actions, metabolism, elimination, and detection. Rodríguez ML MLO Med. Lab. Obs. 45(5), 24, (2013)

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Composite measure to assess efficacy/gastrointestinal tolerability of tapentadol ER versus oxycodone CR for chronic pain: pooled analysis of randomized studies. Merchant S, Provenzano D, Mody S, et al. J. Opioid Manag. 9(1), 51-61, (2013)

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Characterization of prescription opioid abuse in the United States: focus on route of administration. Kirsh K, Peppin J, and Coleman J J. Pain Palliat. Care Pharmacother. 26(4), 348-61, (2012)

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Ask the doctors. I have had back problems for decades, and I have become quite dependent on oxycodone, regardless of whether my back is acting up or not. Now I am going to need heart surgery, but the surgeon I was sent to won't operate unless I can get off the pain pills. That seems cruel. What is he thinking? Lee T and Lee R Harv. Heart Lett. 23(4), 2, (2012)

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Oxycodone + naloxone: choose morphine and optimal laxative therapy instead. Prescrire Int. 22(134), 10-1, (2013)

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[Three cases of cancer-related pain for which oxycodone injection was efficacious]. Shinozaki K, Nitta T, Yamauchi M, et al. Gan To Kagaku Ryoho. 40(1), 119-23, (2013)

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Assessment of the abuse of tapentadol immediate release: the first 24 months. Dart RC, Cicero TJ, Surratt HL, et al. J. Opioid Manag. 8(6), 395-402, (2012)

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Assessing subjective and physiologic effects following intranasal administration of a new formulation of immediate release oxycodone HCl (Oxecta™) tablets in nondependent recreational opioid users. Schoedel KA, Rolleri RL, Faulknor JY, et al. J. Opioid Manag. 8(5), 315-27, (2012)

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Controlled-release oxycodone hydrochloride (OxyContin). Heidrich DE Clin. Nurse Spec. 15(5), 207-9, (2001)

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Prolonged release oxycodone-naloxone for treatment of severe restless legs syndrome after failure of previous treatment: a double-blind, randomised, placebo-controlled trial with an open-label extension. Trenkwalder C, Beneš H, Grote L, et al. Lancet Neurol. 12(12), 1141-50, (2013)

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Self-assembly of thermally responsive nanoparticles of a genetically encoded peptide polymer by drug conjugation. McDaniel JR, Bhattacharyya J, Vargo KB, et al. Angew. Chem. Int. Ed. Engl. 52(6), 1683-7, (2013)

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Decline in drug overdose deaths after state policy changes - Florida, 2010-2012. Johnson H, Paulozzi L, Porucznik C, et al. MMWR Morb. Mortal. Wkly. Rep. 63(26), 569-74, (2014)

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Opioids induce dissociable forms of long-term depression of excitatory inputs to the dorsal striatum. Atwood BK, Kupferschmidt DA, and Lovinger DM Nat. Neurosci. 17(4), 540-8, (2014)

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Central nervous system penetration of oxycodone after intravenous and epidural administration. Kokki M, Välitalo P, Kuusisto M, et al. Br. J. Anaesth. 112(1), 133-40, (2014)

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A poor metabolizer of both CYP2C19 and CYP2D6 identified by mechanistic pharmacokinetic simulation in a fatal drug poisoning case involving venlafaxine. Jornil J, Nielsen TS, Rosendal I, et al. Forensic Sci. Int. 226(1-3), e26-31, (2013)

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A comparison of oxycodone prolonged-release vs. oxycodone + naloxone prolonged-release after laparoscopic hysterectomy. Comelon M, Wisloeff-Aase K, Raeder J, et al. Acta Anaesthesiol. Scand. 57(4), 509-17, (2013)

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Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens. Pravetoni M, Le Naour M, Tucker AM, et al. J. Med. Chem. 56(3), 915-23, (2013)

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Comparison of opioid doctor shopping for tapentadol and oxycodone: a cohort study. Cepeda MS, Fife D, Vo L, et al. J. Pain 14(2), 158-64, (2013)

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Oxymorphone active uptake at the blood-brain barrier and population modeling of its pharmacokinetic-pharmacodynamic relationship. Sadiq MW, Boström E, Keizer R, et al. J. Pharm. Sci. 102(9), 3320-31, (2013)

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Repeatability of gait analysis for measuring knee osteoarthritis pain in patients with severe chronic pain. Asay JL, Boyer KA, and Andriacchi TP J. Orthop. Res. 31(7), 1007-12, (2013)

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Effectiveness of multimodal pain management after bipolar hemiarthroplasty for hip fracture: a randomized, controlled study. Kang H, Ha YC, Kim JY, et al. J. Bone Joint Surg. Am. 95(4), 291-6, (2013)

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Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans. Winchester WJ, Gore K, Glatt S, et al. J. Pharmacol. Exp. Ther. 351(2), 259-69, (2014)

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Repeat dose opioids may be effective for breathlessness in chronic heart failure if given for long enough. Oxberry SG, Bland JM, Clark AL, et al. J. Palliat. Med. 16(3), 250-5, (2013)

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Recent trends in substance abuse among persons with disabilities compared to that of persons without disabilities. Glazier RE and Kling RN Disabil. Health J. 6(2), 107-15, (2013)

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Modulating roles of smoking status and sex on oxycodone-induced nausea and drug liking. Zacny JP, Apfelbaum SM, and Perkins KA Exp. Clin. Psychopharmacol. 21(2), 103-11, (2013)

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Controlled-release oxycodone and naloxone in the treatment of chronic low back pain: a placebo-controlled, randomized study. Cloutier C, Taliano J, O'Mahony W, et al. Pain Res. Manag. 18(2), 75-82, (2013)

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Predictors of alcohol use among rural drug users after disclosure of hepatitis C virus status. Stephens DB and Havens JR J. Stud. Alcohol Drugs 74(3), 386-95, (2013)

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OxyContin use on a rural midwest American Indian reservation: demographic correlates and reasons for using. Momper SL, Delva J, Tauiliili D, et al. Am. J. Public Health 103(11), 1997-9, (2013)

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Long-term patient perception of pain control experience after participating in a trial between patient-controlled analgesia and epidural after pectus excavatum repair with bar placement. Gasior AC, Weesner KA, Knott EM, et al. J. Surg. Res. 185(1), 12-4, (2013)

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Bioequivalence of oxycodone hydrochoride extended release tablets to marketed reference products OxyContin® in Canada and US. Gosai P, Ducharme MP, Godfrey AR, et al. Int. J. Clin. Pharmacol. Ther. 51(11), 895-907, (2013)

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Comparison of a drug versus money and drug versus drug self-administration choice procedure with oxycodone and morphine in opioid addicts. Comer SD, Metz VE, Cooper ZD, et al. Behav. Pharmacol. 24(5-6), 504-16, (2013)

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Narcotic prescribing habits and other methods of pain control by oral and maxillofacial surgeons after impacted third molar removal. Mutlu I, Abubaker AO, and Laskin DM J. Oral Maxillofac. Surg. 71(9), 1500-3, (2013)

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Opioid overdose mortality in Kansas, 2001-2011: toxicologic evaluation of intent. Okic M, Cnossen L, Crifasi JA, et al. J. Anal. Toxicol. 37(9), 629-35, (2013)

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Involvement of α₂-adrenoceptors, imidazoline, and endothelin-A receptors in the effect of agmatine on morphine and oxycodone-induced hypothermia in mice. Bhalla S, Andurkar SV, and Gulati A Fundam. Clin. Pharmacol. 27(5), 498-509, (2013)

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Opioid prescribing patterns after Mohs micrographic surgery and standard excision: a survey of American Society for Dermatologic Surgery members and a chart review at a single institution. Harris K, Calder S, Larsen B, et al. Dermatol. Surg. 40(8), 906-11, (2014)

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Pre-emptive analgesia with pregabalin and celecoxib decreases postsurgical pain following maxillomandibular advancement surgery: a randomized controlled clinical trial. Cillo JE and Dattilo DJ J. Oral Maxillofac. Surg. 72(10), 1909-14, (2014)

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[Opiate induced constipation--mechanisms, relevance and treatment]. Müller-Lissner S Dtsch. Med. Wochenschr. 138(43), 2207-11, (2013)

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Extended-release oxycodone and acetaminophen (Xartemis XR). Med. Lett. Drugs Ther. 56(1447), 59-60, (2014)

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Opioids and restless legs syndrome. Walters AS Lancet Neurol. 12(12), 1128-9, (2013)

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Generic controlled-release oxycodone. Baer PA, Bordman J, and Weinberg EL CMAJ 185(14), 1251-2, (2013)

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FDA ban of generic oxycodone calls into question Health Canada's approval. Miller A CMAJ 185(9), E381-2, (2013)

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Intravesical baclofen, bupivacaine, and oxycodone for the relief of bladder spasm. Wallace E, Twomey M, Victory R, et al. J. Palliat. Care 29(1), 49-51, (2013)

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Aglukkaq asks for US help to control oxycodone. Miller A CMAJ 185(8), E317-8, (2013)

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Reply to commentary. Butler SF J. Pain 14(4), 361-2, (2013)

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Is there support for abuse-deterrent and tamper-resistant opioid formulations? Jamison RN J. Pain 14(4), 359-60, (2013)

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Opioid abuse. Lexchin J CMAJ 185(5), 418, (2013)

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Response to letter by Dr. Ruan. Setnik B, Roland CL, and Webster L Pain Med. 14(1), 161-2, (2013)

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Don't tamper with oxycodone. Fletcher J and Tsuyuki R CMAJ 185(2), 107, (2013)

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Provinces reject federal call for prosecution of over-prescribing physicians. Miller A CMAJ 185(2), E84, (2013)

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Who's writing the script? Miller A CMAJ 185(2), 114-5, (2013)

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Merck 14,6959

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