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PHR1051 Fluka

Propylene glycol

pharmaceutical secondary standard; traceable to USP

Synonym: 1,2-Propanediol, Propylene glycol

  • CAS Number 57-55-6

  • Linear Formula CH3CH(OH)CH2OH

  • Molecular Weight 76.09

  •  Beilstein Registry Number 1340498

  •  E Number E1520

  •  EC Number 200-338-0

  •  MDL number MFCD00064272

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Properties

Related Categories APIs & Metabolites, APIs (Active Pharmaceutical Ingredients) & Metabolites, Additional Standards, Alcohol, All Alphabetically Sorted,
grade   certified reference material
  pharmaceutical secondary standard
vapor density   2.62 (vs air)
vapor pressure   0.08 mmHg ( 20 °C)
form   neat
autoignition temp.   779 °F
expl. lim.   12.5 %
refractive index   n20/D 1.432(lit.)
bp   187 °C(lit.)
mp   −60 °C(lit.)
density   1.036 g/mL at 25 °C(lit.)
pharmacopeia traceability   traceable to USP 1576708

Description

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

General description

Certified Fluka® pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards

Other Notes

This product was designed, produced and verified for accuracy and stability in accordance with ISO/IEC 17025:2005 (AClass Cert AT-1467), ISO GUIDES 34:2009 (AClass Cert AR-1470).

Legal Information

FLUKA is a registered trademark of FLUKA GmbH

Price and Availability

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1,2-Propanediol

puriss. p.a., ACS reagent, ≥99.5% (GC)

1,2-Propanediol

analytical standard

Propylene glycol

United States Pharmacopeia (USP) Reference Standard

Propylene glycol

≥99.5%, FCC, FG

Propylene glycol

European Pharmacopoeia (EP) Reference Standard

Safety & Documentation

Safety Information

WGK Germany 
3
RTECS 
TY2000000
Flash Point(F) 
217.4 °F
Flash Point(C) 
103 °C

Protocols & Articles

Articles

Determination of Water Content in Propanediol Using Karl Fischer Titration

The determination of water in alcohols is straightforward. The substances dissolve very easily in methanol and addition of solubility mediators is only necessary in the case of long chain alcohols. I...
Keywords: Pharmaceutical, Titrations

Related Content

Flavor and Fragrance Analysis

It’s all about your workflow. Sample preparation, separation, detection and analysis. Speed and resolution is key in determining purity or verifying composition.
Keywords: Calorimetry, Gas chromatography, Mass spectrometry, Sample preparations, Separation

Reliable Identification of F&F Components by GC/MS and Linear Retention Indices and Multidimensional Chromatography [VIDEO]

In this on-demand webinar by Prof. Luigi Mondello of the University of Messina, Italy, highlights the shortcomings of GC/MS analysis in the identification of F&F compounds when using a straightforwar...
Keywords: Chromatography, Gas chromatography, High performance liquid chromatography, Mass spectrometry

Peer-Reviewed Papers

References

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LC analysis of benzophenone-3: II application to determination of 'in vitro' and 'in vivo' skin penetration from solvents, coarse and submicron emulsions. Fernandez C, Marti-Mestres G, Ramos J, et al. J. Pharm. Biomed. Anal. 24(1), 155-65, (2000)

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Propylene glycol dermatitis: re-evaluation of an old problem. Funk JO and Maibach HI Contact Dermatitis 31(4), 236-41, (1994)

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Inhibition of skin inflammation in mice by diclofenac in vesicular carriers: liposomes, ethosomes and PEVs. Caddeo C, Sales OD, Valenti D, et al. Int. J. Pharm. 443(1-2), 128-36, (2013)

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The chicken type III GnRH receptor homologue is predominantly expressed in the pituitary, and exhibits similar ligand specificity to the type I receptor. Joseph, N.T., et al. J. Endocrinol. 202, 179, (2009)

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Exposure of German residents to ethylene and propylene glycol ethers in general and after cleaning scenarios. Fromme H, Nitschke L, Boehmer S, et al. Chemosphere 90(11), 2714-21, (2013)

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Modeling the impact of solid surfaces in thermal degradation processes. Tuma C, Laino T, Martin E, et al. ChemPhysChem 14(1), 88-91, (2013)

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GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines. Morgan, K BMC Cancer 11, 476, (2011)

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Use of a human skin in vitro model to investigate the influence of 'every-day' clothing and skin surface decontamination on the percutaneous penetration of organophosphates. Moore CA, Wilkinson SC, Blain PG, et al. Toxicol. Lett. 229(1), 257-64, (2014)

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In vivo and in vitro evaluation of the estrogenic properties of the 17β-(butylamino)-1,3,5(10)-estratrien-3-ol (buame) related to 17β-estradiol. Lemini C, Medina M, Avila ME, et al. Pharmacol. Rep. 64(4), 940-50, (2012)

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Evaluation of activated sludge for biodegradation of propylene glycol as an aircraft deicing fluid. Delorit JD and Racz L Water Environ. Res. 86(4), 366-71, (2014)

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Effect of intratympanic mitomycin C on the development of cholesteatoma and otitis media in rats. Melo AA, Caldas Neto SS, Leão FS, et al. J. Laryngol. Otol. 127(4), 359-63, (2013)

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Systemic contact dermatitis due to intravenous Valium in a person sensitive to propylene glycol. Fisher AA Cutis. 55(6), 327-8, (1995)

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E-cigarettes: The lingering questions. Cressey D Nature 513(7516), 24-6, (2014)

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Are e-cigarettes safe? Maron DF Sci. Am. 310(5), 31-2, (2014)

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Positive propylene glycol result in a patient with ethylene glycol poisoning. Su Z, Stone RW, and Zhu Y Clin. Chem. 60(4), 697-8, (2014)

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Propylene glycol and glycerol concentration in ultrasound gel. Belavy D and Wallis SC Reg. Anesth. Pain Med. 38(1), 75-6, (2013)

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Merck 14,7855

Beil. 1,IV,2468

Aldrich MSDS 1, 1539:C / Arctander, 2696 / Corp MSDS 1 (2), 2949:A / FT-IR 2 (1), 186:D / FT-IR 1 (1), 128:B / FT-NMR 1 (1), 192:C / IR-Spectra (3), 80:B / IR-Spectra (2), 77:F / NMR-Reference 2 (1), 120:B / RegBook 1 (1), 139:C / RegBook 96 (1), 139:C / Sax 6, 2293 / Sigma FT-IR 1 (2), 862:A / Structure Index 1, 16:D:6 / Vapor Phase 3, 188:D

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