Propyl gallate
pharmaceutical secondary standard; traceable to USP and PhEur
DOWNLOAD MSDS (PDF)Synonym:
3,4,5-
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CAS Number 121-79-9
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Linear Formula 3,4,5-(HO)3C6H2CO2CH2CH2CH3
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Molecular Weight 212.20
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Beilstein Registry Number 1877976
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E Number E310
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EC Number 204-498-2
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MDL number MFCD00002196
Properties
| Related Categories | All Alphabetically Sorted, Analytical Standards, Analytical/Chromatography, Chemical Class, Chromatography, |
| grade | certified reference material |
| packaging | pkg of 1 g |
| mp | 146-149 °C(lit.) |
| pharmacopeia traceability | traceable to PhEur P3640000 |
| traceable to USP 1576800 |
Description
General description
This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO Guide 34.
Other Notes
Values of analytes vary lot to lot.
Reconstitution
Prepare a 0.1M solution in glycerol:PBS (9:1)
Application
Used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes such as rhodamine and fluorescein.
Biochem/physiol Actions
An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis. However, propyl gallate induced single strand breaks in DNA at concentrations higher than 0.25 μM when it was combined with copper concentrations at 5 μM and above. Another report, however, found that incubation of isolated rat hepatocytes with propyl gallate at concentrations of >1 mM induced cell killing, whereas, a lower concentration of propyl gallate > 0.5 mM resulted in a ladder formation of soluble low-molecular weight DNA fragments, characteristic of apoptosis.
An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis.
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