Testosterone solution

Papers

Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Giulia Caron et al J. Med. Chem. 48, 3269-79, (2005)

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Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening. Christian Laggner et al J. Med. Chem. 48, 4754-64, (2005)

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Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals. Markus A Lill et al J. Med. Chem. 48, 5666-74, (2005)

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Three-dimensional structure-activity relationships of nonsteroidal ligands in complex with androgen receptor ligand-binding domain. Annu A Söderholm et al J. Med. Chem. 48, 917-25, (2005)

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UDP-glucuronosyltransferases and clinical drug-drug interactions. Tony K L Kiang et al Pharmacol. Ther. 106, 97-132, (2005)

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The transgenic Arabidopsis plant system, pER8-GFP, as a powerful tool in searching for natural product estrogen-agonists/antagonists. Fang-Rong Chang et al J. Nat. Prod. 68, 971-3, (2005)

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Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis. Marieke Voets et al J. Med. Chem. 49, 2222-31, (2006)

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Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability. Giorgio Ottaviani et al J. Med. Chem. 49, 3948-54, (2006)

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Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. Arjan van Oeveren et al J. Med. Chem. 49, 6143-6, (2006)

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Progressive docking: a hybrid QSAR/docking approach for accelerating in silico high throughput screening. Artem Cherkasov et al J. Med. Chem. 49, 7466-78, (2006)

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Synthesis and biological evaluation of lisofylline (LSF) analogs as a potential treatment for Type 1 diabetes. Peng Cui et al Bioorg. Med. Chem. Lett. 16, 3401-5, (2006)

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Androstenediol analogs as ER-beta-selective SERMs. Timothy A Blizzard et al Bioorg. Med. Chem. Lett. 16, 834-8, (2006)

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Multiple N-methylation by a designed approach enhances receptor selectivity. Jayanta Chatterjee et al J. Med. Chem. 50, 5878-81, (2007)

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Effect of structural and conformation modifications, including backbone cyclization, of hydrophilic hexapeptides on their intestinal permeability and enzymatic stability. Shmuel Hess et al J. Med. Chem. 50, 6201-11, (2007)

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In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. Giorgio Ottaviani et al J. Med. Chem. 50, 742-8, (2007)

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Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12. Line Cantin et al J. Biol. Chem. 282, 30910-9, (2007)

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Bridged androstenediol analogs as ER-beta selective SERMs. Timothy A Blizzard et al Bioorg. Med. Chem. Lett. 17, 2944-8, (2007)

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Androstene-3,5-dienes as ER-beta selective SERMs. Timothy A Blizzard et al Bioorg. Med. Chem. Lett. 17, 6295-8, (2007)

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Chemical synthesis and biological activities of 16alpha-derivatives of 5alpha-androstane-3alpha,17beta-diol as antiandrogens. Jenny Roy et al Bioorg. Med. Chem. 15, 3003-18, (2007)

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QSAR study on permeability of hydrophobic compounds with artificial membranes. Masaaki Fujikawa et al Bioorg. Med. Chem. 15, 3756-67, (2007)

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Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bram Baert et al Bioorg. Med. Chem. 15, 6943-55, (2007)

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Hologram QSAR model for the prediction of human oral bioavailability. Tiago L Moda et al Bioorg. Med. Chem. 15, 7738-45, (2007)

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Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. Christopher A Elkins et al Antimicrob. Agents Chemother. 51, 923-9, (2007)

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Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. Sean Ekins et al Drug Metab. Dispos. 35, 493-500, (2007)

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Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. Hiroyuki Sato et al J. Med. Chem. 51, 1831-41, (2008)

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An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin. Artem Cherkasov et al J. Med. Chem. 51, 2047-56, (2008)

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Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Jenny M Pedersen et al J. Med. Chem. 51, 3275-87, (2008)

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Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1). Emmanuel Bey et al J. Med. Chem. 51, 6725-39, (2008)

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(3R)-3-amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Aiko Nitta et al Bioorg. Med. Chem. Lett. 18, 5435-8, (2008)

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Chemometric and chemoinformatic analyses of anabolic and androgenic activities of testosterone and dihydrotestosterone analogues. Yoanna María Alvarez-Ginarte et al Bioorg. Med. Chem. 16, 6448-59, (2008)

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Metabolic stereoselectivity of cytochrome P450 3A4 towards deoxypodophyllotoxin: In silico predictions and experimental validation. Mattijs K Julsing et al Eur. J. Med. Chem. 43, 1171-9, (2008)

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Microbial transformation of isosteviol lactone and evaluation of the transformation products on androgen response element. Bo-Hon Chou et al J. Nat. Prod. 71, 602-7, (2008)

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Microbial transformation of isosteviol and bioactivities against the glucocorticoid/androgen response elements. Shwu-Fen Chang et al J. Nat. Prod. 71, 87-92, (2008)

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Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. José Marco-Contelles et al J. Med. Chem. 52, 2724-32, (2009)

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Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit. Michael L Mohler et al J. Med. Chem. 52, 3597-617, (2009)

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Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. Pelayo Camps et al J. Med. Chem. 52, 5365-79, (2009)

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4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors. Thomas S Dexheimer et al J. Med. Chem. 52, 7122-31, (2009)

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Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators. Nathalie Schlienger et al J. Med. Chem. 52, 7186-91, (2009)

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Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. Mariana P Arce et al J. Med. Chem. 52, 7249-57, (2009)

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Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Lei Du-Cuny et al Bioorg. Med. Chem. 17, 6983-92, (2009)

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Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. Pil H Lee et al Bioorg. Med. Chem. Lett. 20, 69-73, (2010)

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Synthesis of potent, substituted carbazoles as selective androgen receptor modulators (SARMs). Chris P Miller et al Bioorg. Med. Chem. Lett. 20, 7516-20, (2010)

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Selective benzimidazole inhibitors of the antigen receptor-mediated NF-kappaB activation pathway. K. J. Okolotowicz, et al., Bioorg. Med. Chem. 18, 1918-1924, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Neural computational prediction of oral drug absorption based on CODES 2D descriptors. A Guerra et al Eur. J. Med. Chem. 45, 930-40, (2010)

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Membrane transporters in drug development Giacomini, K.M., et al. Nat. Rev. Drug Discov. 9, 215-236, (2010)

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A novel series of piperazinyl-pyridine ureas as antagonists of the purinergic P2Y12 receptor. Peter Bach et al Bioorg. Med. Chem. Lett. 21, 2877-81, (2011)

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QSAR-based permeability model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 19, 2615-24, (2011)

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N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. Gema C González-Muñoz et al Eur. J. Med. Chem. 46, 2224-35, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model. Miriam Redondo et al Eur. J. Med. Chem. 47, 175-85, (2012)

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A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation. Gianpaolo Chiriano et al Eur. J. Med. Chem. 48, 206-13, (2012)

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Merck 14,9180