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8.08261 EMD Millipore

Trifluoroacetic anhydride

Trifluoroacetic anhydride for synthesis. CAS 407-25-0, EC Number 206-982-9, chemical formula (CF₃CO)₂O., for synthesis

Synonym: Bis(trifluoroacetic) anhydride, TFAA

  • CAS Number 407-25-0

  • Linear Formula C₄F₆O₃

  • Molecular Weight 210.03 g/mol

  •  EC Number 206-982-9



Related Categories Biochemicals and Reagents More...
bp   40 °C (1013 hPa)
vapor pressure   405 hPa (20 °C)
density   1.51 g/cm3 (20 °C)
mp   -65 °C
shipped in   ambient
storage temp.   Store below +30°C.
specifications   Assay (GC, area%): ≥ 99.0 % (a/a)
  Density (d 20 °C/ 4 °C): 1.509 - 1.512
  Identity (IR): passes test

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Safety Information

HS Code 
2915 90 70
Hazard Statement(s) 
H314: Causes severe skin burns and eye damage.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.
H412: Harmful to aquatic life with long lasting effects.
EUH014: Reacts violently with water.
Precautionary Statement(s) 
P273: Avoid release to the environment.
P280: Wear protective gloves/ protective clothing/ eye protection/ face protection.
P301 + P330 + P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308 + P310: IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
P403: Store in a well-ventilated place.
Storage class 
8B Non-combustible, corrosive hazardous materials
Organic acid halides, anhydrides and isocyanates can be added dropwise to an excess of methanol (Cat. No. 822283) to convert them into the corresponding methyl esters or methyl carbamates. If necessary, neutralize with sodium hydroxide solution (Cat. No. 105587). Fill into container A.
Hazard Pictogram(s) 
GHS05  GHS05
Hazard Pictogram(s) 
GHS07  GHS07
Hazard Symbols 
Corrosive  Corrosive
Declaration (railroad and road) ADR, RID 
UN 3265 , 8, I
Declaration (transport by air) IATA-DGR 
UN 3265 , 8, I
Declaration (transport by sea) IMDG-Code 
UN 3265 , 8, I, Segregation Group: 1 (Acids)
Categories of danger 
harmful, corrosive, dangerous for the environment
R Phrase 
R 14-20-35-52/53
Reacts violently with water.Harmful by inhalation.Causes severe burns.Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
S Phrase 
S 26-36/37/39-45-61
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).Avoid release to the environment. Refer to special instructions/ Safety data sheets.
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