8.51004 EMD Millipore


BOP Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate Novabiochem®. CAS 56602-33-6, molar mass 442.28 g/mol., Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate Novabiochem®

Synonym: Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphoniumhexafluorophosphate, Castro's Reagent

  • CAS Number 56602-33-6

  • Linear Formula C₁₂H₂₂N₆OP * F₆P

  • Molecular Weight 442.28 g/mol

  •  EC Number 260-279-1



brand family   Novabiochem
packaging   100 g in Plastic bottle (8510040100)
  25 g in Plastic bottle (8510040025)
mp   138 - 145 °C
shipped in   ambient
storage temp.   Store at +2°C to +8°C.
specifications   Colour (visual): white to slight yellow to beige
  Appearance of substance (visual): powder
  Identity (IR): passes test
  Assay (HPLC, area%): ≥ 99.0 % (a/a)
  Solubility (0.6 mmole in 1 ml DMF): clearly soluble


Background information

Peptide coupling reagent which suppresses enantiomerization [1-15]. Reduction of carboxylic acids activated with BOP provides a facile route to alcohols [16].

Novabiochem® recommends the replacement of BOP by PyBOP®(for PyBOP® please see 851009). The manufacture of BOP, as well as its utilization, involves the use or the formation of hexamethylphosphotriamide, the carcinogenicity and respiratory toxicity of which has been the subject of numerous reports.

The product number for this product was previously 01-62-0001.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".

Price and Availability

Ask us for bulk and customization needs

My Chemicals
Safety & Documentation

Safety Information

HS Code 
2933 99 80
Hazard Statement(s) 
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
Precautionary Statement(s) 
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage class 
10 - 13 Other liquids and solids
WGK 3 highly water endangering
Hazard Pictogram(s) 
GHS07  GHS07
Hazard Symbols 
Irritant  Irritant
Categories of danger 
R Phrase 
R 36/37/38
Irritating to eyes, respiratory system and skin.
Protocols & Articles


Peptide Coupling Reagents Selection Guide

The Novabiochem® brand offers one of the most extensive ranges of high-quality coupling reagents for in situ activation on the market. However, with such a plethora of reagents available, the choice ...
Keywords: Condensations, Coupling reactions, Cyclizations, Racemizations, Solid phase peptide synthesis

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?