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PyBOP

PyBOP Novabiochem®. CAS 128625-52-5, molar mass 520.39 g/mol., Novabiochem®

Synonym: Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate

  • CAS Number 128625-52-5

  • Linear Formula C₁₈H₂₈N₆OP * F₆P

  • Molecular Weight 520.39 g/mol

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Properties

brand family   Novabiochem
packaging   100 g in Plastic bottle (8510090100)
  25 g in Plastic bottle (8510090025)
mp   140 - 155 °C
shipped in   ambient
storage temp.   Store at +2°C to +8°C.
specifications   Colour (visual): white to slight yellow to beige
  Appearance of substance (visual): powder
  Identity (IR): passes test
  Assay (HPLC, area%): ≥ 99.0 % (a/a)
  Solubility (1 mmole in 2 ml DMF): clearly soluble

Description

Background information

The standard in situ coupling reagent for solid phase peptide synthesis [1-5]. This product can replace BOP in all applications without loss of performance. Unlike uronium-based reagents, PyBOP® does not give rise to guanidinated by-products during cyclization and fragment condensation reactions.

The product number for this product was previously 01-62-0016.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".

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Safety & Documentation

Safety Information

HS Code 
2933 99 80
Hazard Statement(s) 
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
Precautionary Statement(s) 
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage class 
10 - 13 Other liquids and solids
WGK 
WGK 3 highly water endangering
Hazard Pictogram(s) 
GHS07  GHS07
Hazard Symbols 
Irritant  Irritant
Categories of danger 
irritant
R Phrase 
R 36/37/38
Irritating to eyes, respiratory system and skin.
Protocols & Articles

Articles

Peptide Coupling Reagents Selection Guide

The Novabiochem® brand offers one of the most extensive ranges of high-quality coupling reagents for in situ activation on the market. However, with such a plethora of reagents available, the choice ...
Keywords: Condensations, Coupling reactions, Cyclizations, Racemizations, Solid phase peptide synthesis

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