8.51010 EMD Millipore


PyBroP Novabiochem®. CAS 132705-51-2, molar mass 466.19 g/mol., Novabiochem®

Synonym: Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate

  • CAS Number 132705-51-2

  • Linear Formula C₁₂H₂₄BrN₃P * F₆P

  • Molecular Weight 466.19 g/mol



brand family   Novabiochem
packaging   100 g in Plastic bottle (8510100100)
  25 g in Plastic bottle (8510100025)
mp   >100 °C
storage temp.   Store at +2°C to +8°C.
specifications   Colour (visual): white to slight yellow to beige
  Appearance of substance (visual): powder
  Identity (IR): passes test
  Assay (HPLC, area%): ≥ 98.0 % (a/a)


Background information

A superior reagent for rapid and effective coupling of N-methyl amino acids with low enantiomerization and for other critical applications [1-8].

The coupling of N-methyl amino acids is difficult, and usually only gives low to moderate yields of products which are often contaminated with unwanted diastereomers. Many coupling reagents are ineffective or not practical to use: BOP and HOBt are often useless; BOP-Cl, pivaloyl chloride and Dpp-Cl require long reaction times and preactivation at 0°C.

For coupling α-aminoisobutyric acid (Aib), PyBroP® is most effective when used with dimethylaminopyridine (DMAP) [3].

The product number for this product was previously 01-62-0017.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".

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Safety Information

HS Code 
2933 99 80
Storage class 
10 - 13 Other liquids and solids
WGK 2 water endangering
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