8.51011 EMD Millipore


MSNT Novabiochem®. CAS 74257-00-4, molar mass 296.31 g/mol., Novabiochem®

Synonym: 1-(Mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole

  • CAS Number 74257-00-4

  • Linear Formula C₁₁H₁₂N₄O₄S

  • Molecular Weight 296.31 g/mol



brand family   Novabiochem
packaging   1 g in Glass bottle (8510110001)
  25 g in Plastic bottle (8510110025)
  5 g in Plastic bottle (8510110005)
shipped in   ambient
storage temp.   Store at -15°C to -25°C.
specifications   Colour (visual): white to slight yellow to beige
  Appearance of substance (visual): powder
  Identity (IR): passes test
  Assay (HPLC, area%): ≥ 95.0 % (a/a)


Background information

This versatile reagent was originally used as a coupling reagent in phosphotriester oligonucleotide synthesis [1-3]. In recent years, it has been increasingly used for the esterification of Fmoc-amino acids onto solid phase synthesis supports [4-12]. It has proved particularly effective in difficult cases involving unreactive linkers [8, 9] or enantiomerization prone amino acids [7]. In an investigation [6] into ester formation, in which the alcohol or carboxylic acid component was immobilized on a solid support, MSNT was found to give the best results of all the reagents tested (DCC, DCC/HOBt, DCC/DMAP, Ph3P/DEAD).

The product number for this product was previously 01-62-0021.

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Safety Information

HS Code 
2935 90 90
Storage class 
10 - 13 Other liquids and solids
WGK 3 highly water endangering
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