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HCTU

HCTU O-(1H-6-Chlorobenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem®. CAS 330645-87-9, molar mass 413.69 g/mol., O-(1H-6-Chlorobenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem®

Synonym: 2-(6-Chloro-1-H-benzotriazole-1-yl)-1,1,3,3-tetramethylaminium hexafluorophosphate, HCTU

  • CAS Number 330645-87-9

  • Linear Formula C₁₁H₁₅ClF₆N₅OP

  • Molecular Weight 413.69 g/mol

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Properties

brand family   Novabiochem
packaging   100 g in Fibre case (8510120100)
  25 g in Plastic bottle (8510120025)
mp   >185 °C
shipped in   ambient
storage temp.   Store at +2°C to +8°C.
specifications   Colour (visual): white to off white
  Appearance of substance (visual): powder
  Identity (IR): passes test
  Assay (HPLC, area%): ≥ 98.0 % (a/a)
  Solubility (1 mmole in 2 ml DMF): clearly soluble
  Water (K. F.): ≤ 0.50 %
  For TLC-Systems see our General Catalog

Description

Background information

HCTU [1] is a novel aminium-based coupling reagent, analogous to HBTU, which in comparative studies was found to give superiort results to TBTU in the synthesis of difficult peptides [2], in hindered couplings [3], and cyclizations [4].

The product number for this product was previously 01-62-0038.

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Safety & Documentation

Safety Information

HS Code 
2933 99 80
Hazard Statement(s) 
H228: Flammable solid.
Precautionary Statement(s) 
P210: Keep away from heat.
Storage class 
4.1B Flammable solid hazardous materials
WGK 
WGK 3 highly water endangering
Disposal 
3
Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
Hazard Pictogram(s) 
GHS02  GHS02
Hazard Symbols 
Flammable  Flammable
Declaration (railroad and road) ADR, RID 
UN 1325 , 4.1, II
Declaration (transport by air) IATA-DGR 
UN 1325 , 4.1, II
Declaration (transport by sea) IMDG-Code 
UN 1325 , 4.1, II
Categories of danger 
highly flammable
R Phrase 
R 11
Highly flammable.
Protocols & Articles

Articles

Peptide Coupling Reagents Selection Guide

The Novabiochem® brand offers one of the most extensive ranges of high-quality coupling reagents for in situ activation on the market. However, with such a plethora of reagents available, the choice ...
Keywords: Condensations, Coupling reactions, Cyclizations, Racemizations, Solid phase peptide synthesis

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