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  • 8.51029 - N-Biotinyl-NH-(PEG)₂-COOH . DIPEA (20 atoms)

8.51029 EMD Millipore

N-Biotinyl-NH-(PEG)₂-COOH . DIPEA (20 atoms)


Synonym: O-(N-Biotinyl-3-aminopropyl)-O'-(N-glutaryl-3-aminopropyl)-diethyleneglycol · DIPEA

  • Linear Formula C₂₅H₄₄N₄O₈S * C₈H₁₉N

  • Molecular Weight 698.95 g/mol



brand family   Novabiochem
packaging   1 g in Plastic bottle (8510290001)
  500 mg in Glass bottle (8510298500)
shipped in   ambient
storage temp.   Store at +2°C to +8°C.
specifications   Colour (visual): white to slight yellow to beige
  Appearance of substance (visual): powder
  Identity (IR): passes test
  Purity (TLC(CMA2)): ≥ 98 %
  Assay (HPLC, area%): ≥ 95.0 % (a/a)
  Solubility (50 mg in 1 ml NMP): clearly soluble
  For TLC-Systems see our General Catalog


Background information

The use of this novel biotin derivative incorporates a hydrophilic 20 atom PEG spacer between the peptide and biotin. This not only greatly improves the solubility of the resultant peptide, but reduces steric hindrance between the peptide and biotin, leading to better avidin binding and higher biological activity. The biotin-PEG derivative can be easily incorporated using any standard coupling method as the final step in SPPS, immediately prior to cleavage of the peptide from the resin.

The product number for this product was previously 01-63-0133.

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Safety Information

HS Code 
2934 99 90
Storage class 
10 - 13 Other liquids and solids
WGK 3 highly water endangering
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