8.51085 EMD Millipore


COMU 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy) dimethylaminomorpholino)] uronium hexafluorophosphate Novabiochem®. CAS 1075198-30-9, molar mass 428.27 g/mol., 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy) dimethylaminomorpholino)] uronium hexafluorophosphate Novabiochem®

Synonym: 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)-dimethylamino-morpholino)] uronium hexafluorophosphate

  • CAS Number 1075198-30-9

  • Linear Formula C₁₂H₁₉F₆N₄O₄P

  • Molecular Weight 428.27 g/mol



brand family   Novabiochem
packaging   100 g in Glass bottle (8510850100)
  25 g in Glass bottle (8510850025)
mp   >140 °C
shipped in   ambient
storage temp.   Store at -15°C to -25°C.
specifications   Colour (visual): white to slight yellow to beige
  Appearance of substance (visual): powder
  Identity (IR): passes test
  Assay (HPLC, area%): ≥ 99.0 % (a/a)
  Solubility (10% in acetonitrile): clear


Background information

COMU is a novel reagent which mediates coupling reactions with efficiencies comparable to HATU [1, 2].

It has higher solubility than HATU and HBTU. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents. Recently, the application of COMU in the preparation of esters has been demonstrated [3].

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Safety & Documentation

Safety Information

HS Code 
2934 99 90
Storage class 
10 - 13 Other liquids and solids
WGK 3 highly water endangering
Protocols & Articles


Peptide Coupling Reagents Selection Guide

The Novabiochem® brand offers one of the most extensive ranges of high-quality coupling reagents for in situ activation on the market. However, with such a plethora of reagents available, the choice ...
Keywords: Condensations, Coupling reactions, Cyclizations, Racemizations, Solid phase peptide synthesis

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