8.51090 EMD Millipore


TFFH Tetramethylfluoroformamidinium hexafluorophosphate Novabiochem®. CAS 164298-23-1, molar mass 264.13 g/mol., Tetramethylfluoroformamidinium hexafluorophosphate Novabiochem®

Synonym: Tetramethylfluoroformamidinium hexafluorophosphate,Fluoro-N,N,N',N'-bis(tetramethylene)formamidinium hexafluorophosphate

  • CAS Number 164298-23-1

  • Linear Formula C₅H₁₂F₇N₂P

  • Molecular Weight 264.13 g/mol



brand family   Novabiochem
packaging   25 g in Plastic bottle (8510900025)
  5 g in Glass bottle (8510900005)
mp   104 - 109 °C
storage temp.   Store at +2°C to +8°C.


Background information

TFFH is an in situ coupling reagents which smoothly converts protected amino acids to the corresponding acid fluoride in the presence of base [1]. Acid fluorides have proven are highly effective at coupling hindered amino acids such as α, α-disubstituted amino acids [2].

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Safety Information

HS Code 
2921 29 00
Hazard Statement(s) 
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
Precautionary Statement(s) 
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage class 
10 - 13 Other liquids and solids
WGK 3 highly water endangering
Hazard Pictogram(s) 
GHS07  GHS07
Hazard Symbols 
Irritant  Irritant
R Phrase 
R 36/37/38
Irritating to eyes, respiratory system and skin.
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