8.52008 EMD Millipore


Fmoc-Cys(Trt)-OH Novabiochem®. CAS 103213-32-7, molar mass 585.72 g/mol., Novabiochem®

Synonym: N-α-Fmoc-S-trityl-L-cysteine

  • CAS Number 103213-32-7

  • Linear Formula C₃₇H₃₁NO₄S

  • Molecular Weight 585.72 g/mol



Related Categories Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Cysteine/Cystine, Peptide Chemistry More...
brand family   Novabiochem
packaging   100 g in Plastic bottle (8520080100)
  25 g in Plastic bottle (8520080025)
  250 g in Plastic bottle (8520080250)
mp   164 - 175 °C
shipped in   ambient
storage temp.   Store at -15°C to -25°C.
specifications   Colour (visual): white to off white
  Appearance of substance (visual): powder
  Colour index (0,5 M in DMF): ≤ 150 Hazen
  Identity (IR): passes test
  Enantiomeric purity: ≥ 99.5 % (a/a)
  Purity (HPLC): ≥ 99.0 % (a/a)
  Fmoc-ß-Ala-OH (HPLC): ≤ 0.1 % (a/a)
  Fmoc-ß-Ala-Cys (Trt) -OH (HPLC): ≤ 0.1 % (a/a)
  Fmoc-Cys(Trt)-Cys(Trt)-OH (HPLC): ≤ 0.1 % (a/a)
  Fmoc-Cys-OH (HPLC): ≤ 0.1 % (a/a)
  Assay free amino acid (HPLC): ≤ 0.2 %
  Purity (TLC(011A)): ≥ 98 %
  Purity (TLC(0811)): ≥ 98 %
  Solubility (1 mmole in 2 ml DMF): clearly soluble
  Assay (acidimetric): ≥ 98.0 %
  Water (K. F.): ≤ 2.0 %
  Ethyl acetate (HS-GC): ≤ 0.5 %
  Acetate (IC): ≤ 0.02 %
  For TLC-Systems see our General Catalog


Background information

The standard derivative for Fmoc SPPS of peptides containing Cys [1]. The Trt group is removed with 95% TFA containing 1-5% TIS. Ideally, this derivative should be introduced using the symmetrical anhydride or DIPCDI/HOBt activation [2,3] to minimize enantiomerization. If activation with uronium or phosphonium reagents, such as HBTU or PyBOP®, is to be employed, it is strongly recommended that collidine is used as the base [4], as this has been shown to significantly reduce loss of optical integrity during coupling.

The product number for this product was previously 04-12-1018.

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Safety Information

HS Code 
2930 90 16
Storage class 
10 - 13 Other liquids and solids
WGK 2 water endangering
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