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8.52044 EMD Millipore

FMOC-Asn(Trt)-OH

FMOC-Asn(Trt)-OH N-α-Fmoc-N-ß-trityl-L-asparagine Novabiochem®. CAS 132388-59-1, molar mass 596.69 g/mol., N-α-Fmoc-N-ß-trityl-L-asparagine Novabiochem®

Synonym: N-α-Fmoc-N-β-trityl-L-asparagine

  • CAS Number 132388-59-1

  • Linear Formula C₃₈H₃₂N₂O₅

  • Molecular Weight 596.69 g/mol

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Properties

Related Categories Amino Acids & Derivatives, Asparagine, Chemical Biology, Chemical Synthesis, Peptide Chemistry More...
brand family   Novabiochem
packaging   100 g in Plastic bottle (8520440100)
  25 g in Plastic bottle (8520440025)
  250 g in Plastic bottle (8520440250)
solubility   <0.00005 g/l
mp   210 - 220 °C
LD 50 oral   LD50 Rat > 2000 mg/kg
shipped in   ambient
storage temp.   Store at -15°C to -25°C.
specifications   Colour (visual): white to off white
  Appearance of substance (visual): powder
  Colour index (0,5 M in DMF): ≤ 150 Hazen
  Identity (IR): passes test
  Enantiomeric purity: ≥ 99.7 % (a/a)
  Purity (HPLC): ≥ 99.0 % (a/a)
  Fmoc-ß-Ala-OH (HPLC): ≤ 0.1 % (a/a)
  Fmoc-ß-Ala-Asn (Trt)-OH (HPLC): ≤ 0.1 % (a/a)
  Fmoc-Asn(Trt)-Asn(Trt)-OH (HPLC): ≤ 0.1 % (a/a)
  Fmoc-Asn-OH (HPLC): ≤ 0.1 % (a/a)
  Assay free amino acid (GC): ≤ 0.2 %
  Purity (TLC(011A)): ≥ 98 %
  Purity (TLC(0811)): ≥ 98 %
  Solubility (25 mmole in 50 ml DMF): clearly soluble
  Assay (acidimetric): ≥ 98.0 %
  Water (K. F.): ≤ 2.0 %
  Ethyl acetate (HS-GC): ≤ 0.5 %
  Acetate (IC): ≤ 0.05 %
  For TLC-Systems see our General Catalog

Description

Background information

Fmoc-Asn(Trt)-OH has good solubility properties in most organic solvents, and its use has been shown to result in significantly purer peptides than other derivatives used for the introduction of Asn [1, 2]. Coupling can be performed by standard procedures. The trityl group is normally removed by 95% TFA in 1-3 hours, with no alkylation of Trp residues. When Asn(Trt) is the N-terminal residue, the reaction time may need to be extended to ensure complete deprotection [3].

The product number for this product was previously 04-12-1089.

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Safety & Documentation

Safety Information

HS Code 
2924 29 70
Hazard Statement(s) 
H411: Toxic to aquatic life with long lasting effects.
Precautionary Statement(s) 
P273: Avoid release to the environment.
Storage class 
10 - 13 Other liquids and solids
WGK 
WGK 2 water endangering
Hazard Pictogram(s) 
GHS09  GHS09
Hazard Symbols 
Dangerous for the environment  Dangerous for the environment
Declaration (railroad and road) ADR, RID 
UN 3077 , 9, III
Declaration (transport by air) IATA-DGR 
UN 3077 , 9, III
Declaration (transport by sea) IMDG-Code 
UN 3077 , 9, III, Marine Pollutant: P
Categories of danger 
dangerous for the environment
R Phrase 
R 51/53
Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
S Phrase 
S 61
Avoid release to the environment. Refer to special instructions/ Safety data sheets.
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