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8.52046-M EMD Millipore

Fmoc-Ser(Trt)-OH

Fmoc-Ser(Trt)-OH Novabiochem®. CAS 111061-56-4, molar mass 569.65 g/mol., Novabiochem®

Synonym: N-α-Fmoc-O-trityl-L-serine

  • CAS Number 111061-56-4

  • Linear Formula C₃₇H₃₁NO₅

  • Molecular Weight 569.65 g/mol

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Properties

Related Categories Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Serine More...
brand family   Novabiochem
packaging   100 g in Plastic bottle (8520460100)
  25 g in Plastic bottle (8520460025)
  5 g in Glass bottle (8520460005)
mp   200 °C
shipped in   ambient
storage temp.   Store at -15°C to -25°C.
specifications   Colour (visual): white to slight yellow to beige
  Appearance of substance (visual): powder
  Identity (IR): passes test
  Purity (TLC(157A)): ≥ 98 %
  Purity (TLC(0811)): ≥ 98 %
  Enantiomeric purity: ≥ 99.5 % (a/a)
  Assay (HPLC, area%): ≥ 98.0 % (a/a)
  Solubility (1 mmole in 2 ml DMF): clearly soluble
  Assay (acidimetric): ≥ 95.0 %
  Water (K. F.): ≤ 2.0 %
  For TLC-Systems see our General Catalog

Description

Background information

The side-chain Trt group can be selectively removed with 1% TFA in DCM containing 5% TIS [1, 2] or 20% dichloroacetic acid in DCM [3], enabling the side-chain hydroxyl group to be selectively modified whilst the derivative is attached to the solid support. This is an excellent derivative for the synthesis of phosphoserine containing peptides and peptides modified at the serine side-chain [1]. The use of trityl protected amino acids was shown to result in purer products than when standard t-Bu protected amino acids were utilized [2, 4].

The product number for this product was previously 04-12-1092.

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Safety & Documentation

Safety Information

HS Code 
2924 29 70
Storage class 
10 - 13 Other liquids and solids
WGK 
WGK 2 water endangering
Protocols & Articles
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