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8.52050 EMD Millipore

Fmoc-Trp(Boc)-OH

Fmoc-Trp(Boc)-OH Novabiochem®. CAS 143824-78-6, molar mass 526.59 g/mol., Novabiochem®

Synonym: N-α-Fmoc-N-in-t.-Boc-L-tryptophan

  • CAS Number 143824-78-6

  • Linear Formula C₃₁H₃₀N₂O₆

  • Molecular Weight 526.59 g/mol

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Properties

Related Categories Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Tryptophan More...
brand family   Novabiochem
packaging   100 g in Plastic bottle (8520500100)
  25 g in Plastic bottle (8520500025)
  250 g in Plastic bottle (8520500250)
storage temp.   Store at -15°C to -25°C.
specifications   Colour (visual): white to off white
  Appearance of substance (visual): powder
  Colour index (0,5 M in DMF): ≤ 150 Hazen
  Identity (IR): passes test
  Enantiomeric purity: ≥ 99.7 % (a/a)
  Purity (HPLC): ≥ 97.5 % (a/a)
  Fmoc-ß-Ala-OH (HPLC): ≤ 0.3 % (a/a)
  Fmoc-ß-Ala-Trp (Boc)-OH (HPLC): ≤ 0.1 % (a/a)
  Fmoc-Trp(Boc)-Trp(Boc)-OH (HPLC): ≤ 0.1 % (a/a)
  Fmoc-Trp-OH (HPLC): ≤ 1.0 % (a/a)
  Assay free amino acid (HPLC): ≤ 0.2 %
  Solubility (25 mmole in 50 ml DMF): clear soluble
  Purity (TLC(011A)): ≥ 98 %
  Purity (TLC(0811)): ≥ 98 %
  Assay (acidimetric): ≥ 90.0 %
  Water (K. F.): ≤ 2.0 %
  Ethyl acetate (HS-GC): ≤ 2.5 %
  Acetate (IC): ≤ 0.10 %
  For TLC-Systems see our General Catalog

Description

Background information

The use of this N-in-Boc protected derivative overcomes most of the problems associated with the preparation of Trp containing-peptides by Fmoc SPPS [1]. Cleavage with TFA generates an N-in-carboxy indole which protects the Trp from alkylation [1, 2, 3] and sulfonation [1, 4, 5, 6, 7]. The N-in-carboxy group is removed under aqueous conditions during normal work-up of the peptide.



The product number for this product was previously 04-12-1103.

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Safety Information

HS Code 
2933 99 80
Storage class 
10 - 13 Other liquids and solids
WGK 
WGK 2 water endangering
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