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8.52061 EMD Millipore

Fmoc-(FmocHmb)Leu-OH

Fmoc-(FmocHmb)Leu-OH Novabiochem®. CAS 148515-87-1, molar mass 711.8 g/mol., Novabiochem®

Synonym: N-α-Fmoc-N-α-(2-Fmoc-oxy-4-methoxybenzyl)-L-leucine

  • CAS Number 148515-87-1

  • Linear Formula C₄₄H₄₁NO₈

  • Molecular Weight 711.8 g/mol

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Properties

Related Categories Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Leucine, Peptide Chemistry More...
brand family   Novabiochem
packaging   1 g in Glass bottle (8520610001)
  5 g in Glass bottle (8520610005)
shipped in   ambient
storage temp.   Store at +2°C to +8°C.
specifications   Colour (visual): white to off white
  Appearance of substance (visual): powder
  Identity (IR): passes test
  Enantiomeric purity: ≥ 99.5 % (a/a)
  Purity (TLC(011A)): ≥ 95 %
  Assay (HPLC, area%): ≥ 96.0 % (a/a)
  Solubility (1 mmole in 2 ml CH₂Cl₂): clearly soluble
  Assay (acidimetric): ≥ 90.0 %
  For TLC-Systems see our General Catalog

Description

Background information

Hmb protection of amide bonds has been shown to inhibit aggregation of 'difficult' peptides, thereby leading to products of increased purity [1-6]. Retention of Hmb groups on the cleaved peptide can greatly improve the solubility of protected peptide fragments [7, 8] and otherwise intractable sequences [9-11]. Furthermore, using a Hmb-protected derivative for incorporation of the residue linked to the carboxy group of Asp or Asn residues has been found to suppress formation of aspartimide and piperidide related by-products [12-14]. For a comparison of the efficiency of Hmb and pseudoprolines in preventing aggregation, see [15].

The product number for this product was previously 04-12-1129.

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Safety Information

HS Code 
2924 29 70
Storage class 
10 - 13 Other liquids and solids
WGK 
WGK 2 water endangering
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