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8.52066-M EMD Millipore

Fmoc-Thr(Trt)-OH

Fmoc-Thr(Trt)-OH Novabiochem®. CAS 133180-01-5, molar mass 583.67 g/mol., Novabiochem®

Synonym: N-α-Fmoc-O-trityl-L-threonine

  • CAS Number 133180-01-5

  • Linear Formula C₃₈H₃₃NO₅

  • Molecular Weight 583.67 g/mol

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Properties

Related Categories Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Threonine More...
brand family   Novabiochem
packaging   100 g in Plastic bottle (8520660100)
  25 g in Plastic bottle (8520660025)
  5 g in Plastic bottle (8520660005)
mp   70 - 85 °C
shipped in   ambient
storage temp.   Store at -15°C to -25°C.
specifications   Colour (visual): white to slight yellow to beige
  Appearance of substance (visual): powder
  Identity (IR): passes test
  Enantiomeric purity: ≥ 99.0 % (a/a)
  Purity (TLC(011A)): ≥ 98 %
  Purity (TLC(0811)): ≥ 98 %
  Assay (HPLC, area%): ≥ 98.0 % (a/a)
  Solubility (1 mmole in 2 ml DMF): clearly soluble
  Assay (acidimetric): ≥ 78.0 %
  Water (K. F.): ≤ 1.5 %
  For TLC-Systems see our General Catalog

Description

Background information

The side-chain Trt group can be selectively removed with 1% TFA in DCM containing 5% TIS, enabling the side-chain hydroxyl group to be selectively modified whilst the derivative is attached to the solid support. This is an excellent derivative for the synthesis of phosphothreonine containing peptides and peptides modified at the threonine side-chain [1]. The use of trityl protected amino acids was shown to result in purer products than when standard t-Bu protected amino acids were utilized [2].

The product number for this product was previously 04-12-1141.

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Safety & Documentation

Safety Information

HS Code 
2924 29 70
Storage class 
10 - 13 Other liquids and solids
WGK 
WGK 2 water endangering
Protocols & Articles
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