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8.52070 EMD Millipore

Fmoc-Thr(PO(OBzl)OH)-OH

Fmoc-Thr(PO(OBzl)OH)-OH Novabiochem®. CAS 175291-56-2, molar mass 511.47 g/mol., Novabiochem®

Synonym: N-α-Fmoc-O-benzyl-L-phosphothreonine

  • CAS Number 175291-56-2

  • Linear Formula C₂₆H₂₆NO₈P

  • Molecular Weight 511.47 g/mol

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Properties

Related Categories Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Threonine More...
brand family   Novabiochem
packaging   1 g in Glass bottle (8520700001)
  5 g in Glass bottle (8520700005)
storage temp.   Store at -15°C to -25°C.
specifications   Colour (visual): white to slight yellow to beige
  Appearance of substance (visual): powder
  Identity (IR): passes test
  Optical rotation α 25/D (c=1 in DMF): -6.5 - -3.5 °
  Purity (TLC(CMA1)): ≥ 98 %
  Assay (HPLC, area%): ≥ 98.0 % (a/a)
  Solubility (1 mmole in 2 ml DMF): clearly soluble
  Assay (acidimetric): ≥ 90.0 %
  Water (K. F.): ≤ 2.0 %
  Ethyl acetate (HS-GC): ≤ 0.5 %
  Acetate (IC): ≤ 0.1 %
  For TLC-Systems see our General Catalog

Description

Background information

An excellent building block for the preparation of phosphothreonine-containing peptides [1, 2]. This derivative can be introduced using standard activation methods, such as PyBOP® and TBTU. The monoprotected phosphothreonine residue once incorporated is stable to piperidine. Using this reagent, even peptides containing multiple phosphorylation sites can be prepared efficiently by standard Fmoc SPPS methods [1].

A paper describes the use of this derivative in the preparation of phospholamban [3], a 52 residue peptide containing both phosphoserine and phosphothreonine.

The product number for this product was previously 04-12-1155.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".

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Safety Information

HS Code 
2924 29 70
Storage class 
10 - 13 Other liquids and solids
WGK 
WGK 2 water endangering
Protocols & Articles
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