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Fmoc-(Dmb)Gly-OH

Fmoc-(Dmb)Gly-OH Novabiochem®. CAS 166881-42-1, molar mass 447.48 g/mol., Novabiochem®

Synonym: N-α-Fmoc-N-α-(2, 4-dimethoxybenzyl)-glycine

  • CAS Number 166881-42-1

  • Linear Formula C₂₆H₂₅NO₆

  • Molecular Weight 447.48 g/mol

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Properties

Related Categories Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Glycine, Peptide Chemistry More...
brand family   Novabiochem
packaging   1 g in Glass bottle (8521100001)
  5 g in Plastic bottle (8521100005)
storage temp.   Store at -15°C to -25°C.
specifications   Colour (visual): white to slight yellow to beige
  Appearance of substance (visual): powder
  Identity (IR): passes test
  Purity (TLC(157B)): ≥ 98 %
  Assay (HPLC, area%): ≥ 99.0 % (a/a)
  Solubility (1 mmole in 2 ml DMF): passes test
  Assay (acidimetric): ≥ 94.0 %
  Water (K. F.): ≤ 1.00 %
  For TLC-Systems see our General Catalog

Description

Background information

Fmoc-(Dmb)Gly-OH is an excellent reagent for enhancing synthetic efficiency of glycine-containing peptides.

Like the analogous Hmb derivative Fmoc-(FmocHmb)Gly-OH, the use of this derivative prevents aggregation during chain assemby, thereby leading to faster and more predictable acylation and deprotection reactions. Furthermore, it can prevent aspartimide formation when used to introduce a Gly immediately before an Asp residue and help promote cyclization of Gly-containing peptides [1].

The analogous (Tmob)Gly derivative has been used by Bayer and colleagues to prepare a 64-residue transmembrane peptide in remarkable purity [2].

The product number for this product was previously 04-12-1268.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".

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Safety Information

HS Code 
2924 29 70
Storage class 
10 - 13 Other liquids and solids
WGK 
WGK 2 water endangering
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