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8.52119 EMD Millipore

Fmoc-Asn(Dmcp)-OH

Fmoc-Asn(Dmcp)-OH Novabiochem®. CAS 172947-19-2, molar mass 436.5 g/mol., Novabiochem®

Synonym: N-α-Fmoc-N-β-(1-cyclopropyl-1-methylethyl)-L-asparagine

  • CAS Number 172947-19-2

  • Linear Formula C₂₅H₂₈N₂O₅

  • Molecular Weight 436.5 g/mol

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Properties

Related Categories Amino Acids & Derivatives, Asparagine, Chemical Biology, Chemical Synthesis, Peptide Chemistry More...
brand family   Novabiochem
packaging   1 g in Glass bottle (8521190001)
  5 g in Plastic bottle (8521190005)
shipped in   ambient
storage temp.   Store at -15°C to -25°C.
specifications   Colour (visual): white to slight yellow to beige
  Appearance of substance (visual): powder
  Identity (IR): passes test
  Optical rotation α 25/D (c=1 in CH₂Cl₂): +60.0 - +66.0 °
  Purity (TLC(CMA2)): ≥ 98.0 %
  Assay (HPLC, area%): ≥ 98.0 % (a/a)
  Solubility (1 mmole in 2 ml DMF): clearly soluble
  Assay (acidimetric): ≥ 95.0 %
  Water (K. F.): ≤ 2.00 %
  For TLC-Systems see our General Catalog

Description

Background information

A superior derivative to Fmoc-Asn(Trt)-OH for the synthesis of Asn-containing peptides by Fmoc SPPS. Fmoc-Asn(Dmcp)-OH is more soluble in DMF than Fmoc-Asn(Trt)-OH, thereby facilitating coupling reactions at higher concentration. Cleavage of the Dmcp group is rapid, even when the residue is located at the N-terminus of a peptide. Coupling of Dmcp-protected derivatives is faster than that of the corresponding hindered Trt derivatives. Dmcp-protected peptides have enhanced solubility.

The product number for this product was previously 04-12-1291.

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Safety Information

HS Code 
2924 29 70
Storage class 
10 - 13 Other liquids and solids
WGK 
WGK 2 water endangering
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