8.52120 EMD Millipore


Fmoc-Gln(Dmcp)-OH Novabiochem®. CAS 172947-20-5, molar mass 450.53 g/mol., Novabiochem®

Synonym: N-α-Fmoc-N-γ-(1-cyclopropyl-1-methylethyl)-L-glutamine

  • CAS Number 172947-20-5

  • Linear Formula C₂₆H₃₀N₂O₅

  • Molecular Weight 450.53 g/mol



Related Categories Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Glutamine, Peptide Chemistry More...
brand family   Novabiochem
packaging   1 g in Glass bottle (8521200001)
  5 g in Plastic bottle (8521200005)
storage temp.   Store at -15°C to -25°C.
specifications   Colour (visual): white to slight yellow to beige
  Appearance of substance (visual): powder
  Identity (IR): passes test
  Optical rotation α 25/D (c=1 in DMF): -12.0 - -9.0 °
  Purity (TLC(CMA2)): ≥ 98 %
  Assay (HPLC, area%): ≥ 98.0 % (a/a)
  Solubility (1 mmole in 2 ml DMF): clearly soluble
  Assay (acidimetric): ≥ 90.0 %
  Water (K. F.): ≤ 1.00 %
  For TLC-Systems see our General Catalog


Background information

A superior derivative to Fmoc-Gln(Trt)-OH for the synthesis of Gln-containing peptides by Fmoc SPPS. Fmoc-Gln(Dmcp)-OH is more soluble in DMF than Fmoc-Gln(Trt)-OH, thereby facilitating coupling reactions at higher concentration. Cleavage of the Dmcp group is rapid, even when the residue is located at the N-terminus of a peptide. Coupling of Dmcp-protected derivatives is faster than that of the corresponding hindered Trt derivatives. Dmcp-protected peptides have enhanced solubility.

The product number for this product was previously 04-12-1292.

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Safety Information

HS Code 
2924 29 70
Storage class 
10 - 13 Other liquids and solids
WGK 2 water endangering
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