8.52287 EMD Millipore


Fmoc-p-Bz-Phe-OH Fmoc-L-p-benzoylphenylalanine Novabiochem®. CAS 117666-96-3, molar mass 491.53 g/mol., Fmoc-L-p-benzoylphenylalanine Novabiochem®

Synonym: (S)-3-(4-Benzoyl-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid,4-Benzoyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]phenylalanine

  • CAS Number 117666-96-3

  • Linear Formula C₃₁H₂₅NO₅

  • Molecular Weight 491.53 g/mol



Related Categories Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Phenylalanine More...
brand family   Novabiochem
packaging   1 g in Glass bottle (8522870001)
  5 g in Glass bottle (8522870005)
shipped in   ambient
storage temp.   Store at +2°C to +8°C.
specifications   Colour (visual): white to slight yellow to beige
  Appearance of substance (visual): powder
  Identity (IR): passes test
  Optical rotation α 25/D (c=1 in DMF): -31.0 - -27.0 °
  Assay (HPLC, area%): ≥ 98.0 % (a/a)
  Solubility (1 mmole in 2 ml DMF): clearly soluble


Background information

Fmoc-p-Bz-Phe-OH-OH is a useful tool for preparing photoactivatable peptide-based affinity probes [1]. On photolysis at 366 nm, Benzoylphenylalanine (Bpa) generates a biradical that has a preference for insertion into C-H bonds, particularly those of Leu, Val and Met side chains.

The derivative can be introduced using standard coupling method such as PyBOP and is stable to conditions used in peptide chain extension. For the cleavage of Bpa containing peptide from the resin, the use of thiols and silanes should be avoided as dithioketal formation and reduction, respectively, have been observed.

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HS Code 
2924 29 70
Storage class 
10 - 13 Other liquids and solids
WGK 2 water endangering
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