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8.55054 EMD Millipore

EDANS NovaTag™_resin

Novabiochem®

Synonym: EDANS-MPB-AM resin

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Properties

brand family   Novabiochem
packaging   100 mg in Glass bottle (8550548100)
  500 mg in Glass bottle (8550548500)
shipped in   ambient
storage temp.   Store at -15°C to -25°C.
specifications   Colour (visual): white to yellow to brown
  Appearance of substance (visual): beads
  Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.30 - 0.60 mmol/g
  Swelling Volume (in DMF): lot specific result
  The polymer matrix is copoly styrene - 1 & DVB 100 - 200 mesh

Description

Background information

The EDANS/dabcyl fluorophore-quencher pair is one of the most commonly-used for FRET peptides, owing to excellent spectral overlap between the emission spectrum of EDANS and absorbance spectrum of dabcyl [1]. The introduction of the EDANS moiety is traditionally achieved either by coupling of a peptide fragment to EDANS in solution [1, 2] or through the use of a pre-formed derivative, such as Fmoc-Glu(EDANS)-OH [3]. Novabiochem's EDANS resin enables for the first time the direct synthesis of C-terminally EDANS-labeled peptides by solid phase synthesis [4]. Loading of the first residue requires acylation of the resin-bound secondary amine and is, therefore, best carried out using HATU activation. Chain extension and cleavage can then be effected using standard methods.

EDANS NovaTag™ resin has been recently employed to prepare fluorescently labeled aminoalkane diphenyl phosphonate affinity probes for chymotrypsin- and elastase-like serine proteases [5].



The product number for this product was previously 04-12-3904.

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Safety Information

HS Code 
3903 90 90
Storage class 
10 - 13 Other liquids and solids
WGK 
WGK 1 slightly water endangering
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