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8.55055 EMD Millipore

Biotin-PEG NovaTag™ resin

Novabiochem®

Synonym: N-Biotin-NÆ-Fmoc-PEG-diamine-MPB-AM resin

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Properties

brand family   Novabiochem
packaging   1 g in Glass bottle (8550550001)
  500 mg in Glass bottle (8550558500)
shipped in   ambient
storage temp.   Store at -15°C to -25°C.
specifications   Colour (visual): white to yellow to beige
  Appearance of substance (visual): beads
  Loading (photometric determination of the Fmoc-chromophore liberated upon treatment with piperidine/DMF.): 0.20 - 0.50 mmol/g
  Swelling Volume (in DMF): lot specific result
  The polymer matrix is copoly (styrene-1 % DVB), 100 -200 mesh

Description

Background information

Biotin NovaTag™ resin is an ideal tool for the synthesis of peptides labeled iwth biotin. As the biotin moiety is incorporated into the linker, its use eliminates the problems associated with biotin-labeling of peptides, namely poor solubility and sluggish coupling kinetics of biotin and its derivatives.

Attachment of the first amino acid should be effected using HATU/DIPEA. Following peptide assembly under standard Fmoc SPPS conditions, cleavage with TFA affords the peptide labeled with biotin.

Biotin-PEG NovaTag™ resin incorporates a PEG spacer into the peptide, which leads to products having better solubilities compared to those prepared using standard biotin derivatives [1]. Furthermore, the PEG spacer reduces steric hindrance between the peptide and avidin, leading to better binding of biotin. For recent applications, see [2, 3].

The product number for this product was previously 04-12-3908.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".

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Safety & Documentation

Safety Information

HS Code 
3903 90 90
Storage class 
10 - 13 Other liquids and solids
WGK 
WGK 3 highly water endangering
Protocols & Articles
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