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  • 8.55059 - Merrifield resin LL (100-200 mesh)

8.55059 EMD Millipore

Merrifield resin LL (100-200 mesh)


Synonym: Chloromethylpolystyrene-divinylbenzene (100-200 mesh)



brand family   Novabiochem
packaging   100 g in Plastic bottle (8550590100)
  25 g in Plastic bottle (8550590025)
  5 g in Glass bottle (8550590005)
shipped in   ambient
storage temp.   Store below +30°C.
specifications   Colour (visual): white to yellow to beige
  Appearance of substance (visual): beads
  Loading (determined by elemental analysis for sulfur after derivatization with KSAc): 0.40 - 1.00 mmol/g
  Swelling Volume (in CH₂Cl₂): lot specific result
  The polymer matrix is copoly (styrene-1 % DVB), 100 -200 mesh (75 - 150 µm)


Background information

Merrifield resin was the standard support for the synthesis of peptide acids by Boc SPPS [1, 2]. In peptide chemistry, it is now really only used in the synthesis of small to medium sized peptides, as the benzylic ester resin linkage is not completely stable towards repetitive treatment with TFA.

Attachment of the C-terminal residue is generally achieved by heating the resin in DMF with the appropriate amino acid cesium salt in the presence of KI [3]; although, Me4N salts [4], sodium salts [5] in THF with Bu4NF catalysis [6] and zinc salts in EtOH have also been used [7].

Cleavage is normally effected by treatment of resin with HF or TFMSA, or by hydrogenolysis [8]. Alcohols can be released using reducing agents such as DIBAL [6] or LiBH4 [9]. Methyl esters can be produced by transesterification with methoxide [10].

The product number for this product was previously 01-64-0008.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".

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Safety Information

HS Code 
3903 90 90
Storage class 
10 - 13 Other liquids and solids
WGK 1 slightly water endangering
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