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  • 8.55060 - Rink Acid resin (100-200 mesh)

8.55060 EMD Millipore

Rink Acid resin (100-200 mesh)


Synonym: 4-(2',4'-Dimethoxyphenyl-hydroxymethyl)-phenoxy resin



brand family   Novabiochem
packaging   1 g in Plastic bottle (8550600001)
  25 g in Plastic bottle (8550600025)
  5 g in Glass bottle (8550600005)
storage temp.   Store below +30°C.
specifications   Colour (visual): white to yellow to beige
  Appearance of substance (visual): beads
  Loading (determined from the substition of the Fmoc-NH2 loaded resin): 0.35 - 0.80 mmol/g
  Swelling Volume (in DMF): lot specific result
  The polymer matrix is copoly (styrene - 1% DVB) 100 -200 mesh


Background information

Rink acid resin is a super acid-labile support for the solid phase immobilization of carboxylic acids [1]. Cleavage can be effected with as little as 10% AcOH in DCM, providing highly acid-sensitive products in high yields and purities. However, care must be taken to prevent product loss during synthetic manipulations [2], owing to the extreme acid sensitivity of this support.

Treatment with HCl in THF [3] or Ph3PCl2 [4] has been shown to efficiently convert this resin to the corresponding benzhydryl chloride, to which can be coupled a wide range of functional groups: hydroxylamines [3], alcohols, amines, acids and thiols [4].

Rink acid resin has also been converted to a trifluoroacetate with TFA and used in a similar manner to immobilize amines, thiols, alcohols, and phenols [5]. In a more detailed study, the same authors found 1 M trifluoroacetic anhydride in 2,6-lutidine to give superior results with less degradation of the linker [6, 7]. Rink resin trifluoroacetate has also been used to prepare purines [8, 9].

Cleavage of amines and alcohols from this support has been carried out with either 5% TFA in DCM [4] or 20% TFA in DCM [5]; thiols were released with either 5% TFA in DCM [4] or 95% aq. TFA [5].

The product number for this product was previously 01-64-0012.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".

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Safety Information

HS Code 
3903 90 90
Storage class 
10 - 13 Other liquids and solids
WGK 1 slightly water endangering
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