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8.55061 EMD Millipore

HMPB-MBHA resin

Novabiochem®

Synonym: 4-Hydroxymethyl-3-methoxyphenoxybutyric acid MBHA resin

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Properties

brand family   Novabiochem
packaging   1 g in Glass bottle (8550610001)
  5 g in Glass bottle (8550610005)
shipped in   ambient
storage temp.   Store below +30°C.
specifications   Colour (visual): white to yellow to beige
  Appearance of substance (visual): beads
  Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.40 - 1.00 mmol/g
  Swelling Volume (in DMF): lot specific result
  The polymer matrix is copoly ( styrene - 1% DVB ) 100- 200 mesh

Description

Background information

This support consists of MBHA resin functionalized with Riniker's hyperacid-labile 4-hydroxymethyl-3-methoxyphenoxybutyric acid linker [1].

This hyperacid-sensitive resin is a useful tool for the Fmoc SPPS of protected peptide acid fragments.

Attachment of carboxylic acids is normally achieved by DMAP catalyzed esterification with the appropriate symmetrical anhydride, or by using 2,6-dichlorobenzoyl chloride/pyridine [2] or MSNT/Melm activation [3, 4, 5].

Detachment of these functionalities can be effected by treatment with 1-5% TFA in DCM.

The product number for this product was previously 01-64-0036.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".

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Safety & Documentation

Safety Information

HS Code 
3903 90 90
Storage class 
10 - 13 Other liquids and solids
WGK 
WGK 1 slightly water endangering
Protocols & Articles
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