8.55074 EMD Millipore

Weinreb AM resin


Synonym: N-Fmoc- N-methoxy-β-alanine AM resin



brand family   Novabiochem
packaging   1 g in Plastic bottle (8550740001)
  25 g in Plastic bottle (8550740025)
  5 g in Plastic bottle (8550740005)
shipped in   ambient
storage temp.   Store below +30°C.
specifications   Colour (visual): white to yellow to beige
  Appearance of substance (visual): beads
  Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 1.00 mmol/g
  Swelling Volume (in CH₂Cl₂): lot specific result
  The polymer matrix is copoly (styrene - 1 % DVB), 100 - 200 mesh


Background information

This support is useful for the production of peptide aldehydes and other carboxaldehydes. Following removal of the Fmoc group with 20% piperidine in DMF, acylation of the resin-bound methoxylamine is best effected using DIPCDI/HOAt or HATU/DIPEA activation. This results in formation of a supported Weinreb-type amide which can be either reduced to an aldehyde with LiAlH4 [1, 2] or cleaved with Grignard reagents to give ketones [2, 3].

The product number for this product was previously 01-64-0153.

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Safety Information

HS Code 
3903 90 90
Storage class 
10 - 13 Other liquids and solids
WGK 1 slightly water endangering
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