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02575 Sigma-Aldrich

Dichloromethane

analytical standard

Synonym: Methylene chloride

  • CAS Number 75-09-2

  • Empirical Formula (Hill Notation) CH2Cl2

  • Molecular Weight 84.93

  •  Beilstein Registry Number 1730800

  •  EC Number 200-838-9

  •  MDL number MFCD00000881

  •  PubChem Substance ID 329747461

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Properties

Related Categories Additional Standards, Alpha Sort, Analytical Standards, Analytical/Chromatography, Applications,
grade   analytical standard
vapor density   2.9 (vs air)
vapor pressure   24.45 psi ( 55 °C)
  6.83 psi ( 20 °C)
InChI Key   YMWUJEATGCHHMB-UHFFFAOYSA-N
assay   ≥99.9% (GC)
autoignition temp.   1223 °F
shelf life   limited shelf life, expiry date on the label
contains   0.002% amylene as stabilizer
expl. lim.   22 %
refractive index   n20/D 1.424(lit.)
  n20/D 1.424
bp   39.8-40 °C(lit.)
mp   −97 °C(lit.)
density   1.325 g/mL at 25 °C(lit.)

Description

General description

Dichloromethane (methylene chloride) is a clear, colorless, non-flammable, volatile liquid chlorinated hydrocarbon with a sweet, pleasant smell and emits highly toxic fumes of phosgene when heated to decomposition. It is primarily used as a solvent in paint removers, in aerosol formulations, and as a solvent in the manufacture of pharmaceuticals. It is also used as a degreasing agent in electronics manufacturing and as an ethane foam blowing agent..1 Above all that it is used as an extraction solvent in the preparation of decaffeinated coffee, hop extracts and spice oleoresins.

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Pharma QC
Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Blood, Central nervous system, Liver
RIDADR 
UN 1593 6.1 / PGIII
WGK Germany 
2
RTECS 
PA8050000
Protocols & Articles

Articles

GC Analysis of Class 2 Residual Solvents on Equity®-1 after SPME using 85 μm Polyacrylate Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Class 2 Residual Solvents on Equity®-1 after SPME using 85 μm Polyacrylate Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Size-exclusion chromatography, Solid phase microextractions

GC Analysis of Class 2 Residual Solvents on OVI-G43

From our library of Articles, Sigma-Aldrich presents GC Analysis of Class 2 Residual Solvents on OVI-G43
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Size-exclusion chromatography

GC Analysis of Class 2 Residual Solvents on VOCOL® after SPME using 85 μm Polyacrylate Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Class 2 Residual Solvents on VOCOL® after SPME using 85 μm Polyacrylate Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Size-exclusion chromatography, Solid phase microextractions

GC Analysis of Industrial Solvents on Equity®-1701

From our library of Articles, Sigma-Aldrich presents GC Analysis of Industrial Solvents on Equity®-1701
Keywords: Chromatography, Flame ionization detector, Gas chromatography

GC Analysis of Industrial Solvents on Equity®-1

From our library of Articles, Sigma-Aldrich presents GC Analysis of Industrial Solvents on Equity®-1
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification, Size-exclusion chromatography

GC Analysis of Industrial Solvents on SUPELCOWAX 10

From our library of Articles, Sigma-Aldrich presents GC Analysis of Industrial Solvents on SUPELCOWAX 10
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification

GC Analysis of Residual Solvents on Equity®-5

From our library of Articles, Sigma-Aldrich presents GC Analysis of Residual Solvents on Equity®-5
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Purification, Size-exclusion chromatography

GC Analysis of Residual Solvents on SPB®-624 after SPME using 100 μm PDMS Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Residual Solvents on SPB®-624 after SPME using 100 μm PDMS Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Purification, Sample preparations, Solid phase microextractions

GC Analysis of Solvents on a Packed Column (3% SP-1500 on Carbopack™ B)

From our library of Articles, Sigma-Aldrich presents GC Analysis of Solvents on a Packed Column (3% SP-1500 on Carbopack™ B)
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification

GC Analysis of Volatiles in Water on Equity®-1 after SPME using 30 μm PDMS Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Volatiles in Water on Equity®-1 after SPME using 30 μm PDMS Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification, Size-exclusion chromatography, Solid phase microextractions

GC Analysis of Volatiles in Water on SPB®-1 after SPME using 100 μm PDMS Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Volatiles in Water on SPB®-1 after SPME using 100 μm PDMS Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification, Solid phase microextractions

GC Analysis of Volatiles on SPB®-624, Direct Injection

From our library of Articles, Sigma-Aldrich presents GC Analysis of Volatiles on SPB®-624, Direct Injection
Keywords: Chromatography, Gas chromatography, Purification, Size-exclusion chromatography

GC Analysis of Volatiles on VOCOL® after SPME using 75 μm Carboxen/PDMS Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Volatiles on VOCOL® after SPME using 75 μm Carboxen/PDMS Fiber
Keywords: Chromatography, Gas chromatography, Mass spectrometry, Purification, Solid phase microextractions

GC Analysis of a 12-Component Chlorinated Solvents Mix on SLB®-IL60, Comparison to a Polyethylene Glycol (PEG) Column

From our library of Articles, Sigma-Aldrich presents GC Analysis of a 12-Component Chlorinated Solvents Mix on SLB®-IL60, Comparison to a Polyethylene Glycol (PEG) Column
Keywords: Chromatography, Flame ionization detector, Gas chromatography

GC Analysis of a 56-Component Industrial Solvents Mix on SLB®-IL60, Comparison to a Polyethylene Glycol (PEG) Column

From our library of Articles, Sigma-Aldrich presents GC Analysis of a 56-Component Industrial Solvents Mix on SLB®-IL60, Comparison to a Polyethylene Glycol (PEG) Column
Keywords: Chromatography, Flame ionization detector, Gas chromatography

The Utility of Headspace Grade Solvents for the Analysis of Organic Volatile Impurities

Organic volatile impurities or “OVIs” sometimes remain behind in pharmaceutical preparations as a result of synthetic and manufacturing procedures. For reasons of health and safety, testing is done t...
Katherine Stenerson, Shyam Verma
Reporter US Volume 28.1
Keywords: Chromatography, Gas chromatography, Organic synthesis, Pharmaceutical, Solvents

US EPA Method 0030: GC Analysis of Volatiles on SPB®-624 after Collection/Desorption using VOST 100 Tube

From our library of Articles, Sigma-Aldrich presents US EPA Method 0030: GC Analysis of Volatiles on SPB®-624 after Collection/Desorption using VOST 100 Tube
Keywords: Air Monitoring, Chromatography, Flame ionization detector, Gas chromatography, Purification

US EPA Method 502.2: GC Analysis of Volatiles on VOCOL® (105 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap, ELCD Signal

From our library of Articles, Sigma-Aldrich presents US EPA Method 502.2: GC Analysis of Volatiles on VOCOL® (105 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap, ELCD Signal
Keywords: Chromatography, Gas chromatography, Hall electrolytic conductivity detector, Photo-ionization detector, Purge and trap, Sample preparations

US EPA Method 502.2: GC Analysis of Volatiles on VOCOL® (105 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap, PID Signal

From our library of Articles, Sigma-Aldrich presents US EPA Method 502.2: GC Analysis of Volatiles on VOCOL® (105 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap, PID Signal
Keywords: Chromatography, Gas chromatography, Hall electrolytic conductivity detector, Photo-ionization detector, Purification

US EPA Method 524.2: GC Analysis of Volatiles on VOCOL® (105 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap

From our library of Articles, Sigma-Aldrich presents US EPA Method 524.2: GC Analysis of Volatiles on VOCOL® (105 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap
Keywords: Chromatography, Gas chromatography, Purification, Size-exclusion chromatography

US EPA Method 624: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents US EPA Method 624: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis
Keywords: Chromatography, Environmental, Gas chromatography, Purification, Solid phase microextractions

US EPA Method 624: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap

From our library of Articles, Sigma-Aldrich presents US EPA Method 624: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap
Keywords: Chromatography, Environmental, Gas chromatography, Purification, Solid phase microextractions

US EPA Method 624: GC Analysis of Volatiles on VOCOL® (60 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap

From our library of Articles, Sigma-Aldrich presents US EPA Method 624: GC Analysis of Volatiles on VOCOL® (60 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap
Keywords: Chromatography, Gas chromatography, Purification, Size-exclusion chromatography

US EPA Method 8260: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents US EPA Method 8260: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis
Keywords: Chromatography, Gas chromatography, Gas chromatography mass spectrometry, Mass spectrometry, Purge and trap, Purification, Solid phase microextractions

US EPA Method 8260: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap

From our library of Articles, Sigma-Aldrich presents US EPA Method 8260: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap
Keywords: Chromatography, Environmental, Gas chromatography, Purification, Solid phase microextractions

US EPA Method 8260: GC Analysis of Volatiles on VOCOL® after Purge & Trap using "K" Trap, Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents US EPA Method 8260: GC Analysis of Volatiles on VOCOL® after Purge & Trap using "K" Trap, Fast GC Analysis
Keywords: Chromatography, Gas chromatography, Purification, Solid phase microextractions

US EPA Method 8260: GC Analysis of Volatiles on VOCOL® after Purge & Trap using "K" Trap

From our library of Articles, Sigma-Aldrich presents US EPA Method 8260: GC Analysis of Volatiles on VOCOL® after Purge & Trap using "K" Trap
Keywords: Chromatography, Gas chromatography, Purification, Solid phase microextractions

US EPA Method OLM04.2 VOA: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents US EPA Method OLM04.2 VOA: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis
Keywords: Chromatography, Environmental, Gas chromatography, Purification, Solid phase microextractions

US EPA Method OLM04.2 VOA: GC Analysis of Volatiles on VOCOL® after Purge & Trap using "K" Trap, Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents US EPA Method OLM04.2 VOA: GC Analysis of Volatiles on VOCOL® after Purge & Trap using "K" Trap, Fast GC Analysis
Keywords: Chromatography, Environmental, Gas chromatography, Purification, Solid phase microextractions

US EPA Method TO-17: GC Analysis of Volatiles on Equity®-1 after Collection/Desorption using Carbotrap 300 Tube

From our library of Articles, Sigma-Aldrich presents US EPA Method TO-17: GC Analysis of Volatiles on Equity®-1 after Collection/Desorption using Carbotrap 300 Tube
Keywords: Chromatography, Gas chromatography

US EPA Method TO-17: GC Analysis of Volatiles on VOCOL® after Collection/Desorption using Air Toxics Tube

From our library of Articles, Sigma-Aldrich presents US EPA Method TO-17: GC Analysis of Volatiles on VOCOL® after Collection/Desorption using Air Toxics Tube
Keywords: Air Monitoring, Chromatography, Flame ionization detector, Gas chromatography, Purification

Peer-Reviewed Papers
15

References

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