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02580 Sigma-Aldrich

O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N′,N′-tetramethyluronium tetrafluoroborate

≥98.0% (CHN)

Synonym: N-[[[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy](dimethylamino)methylene]-N-methyl-methanaminium tetrafluoroborate, TOTU

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Properties

Related Categories Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry, Peptide Coupling,
InChI Key   FPQVGDGSRVMNMR-JCTPKUEWSA-N
assay   ≥98.0% (CHN)
mp   144-145 °C
  145 °C (dec.)(lit.)
storage temp.   2-8°C

Description

Other Notes

New uronium-based coupling reagent for peptide synthesis suitable for critical cases

Same product — same quality — now Sigma-Aldrich brand

Application

Reactant for:
Watson-Crick pairing of oligonucleotides
Esterification of nucleosides to solid phase supports
Reagent for:
Synthesis of selective integrin avβ3 antagonists
Design and synthesis of double stranded DNA libraries
Preparation of conformationally contrained β-amino acid derivatives
Synthesis and application of methyleneoxy pseudopeptide building blocks

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

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Peer-Reviewed Papers
15

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