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06566 Sigma-Aldrich

4-Amidinophenylmethanesulfonyl fluoride hydrochloride

≥97.0% (AT)

Synonym: 4-Amidinobenzylsulfonyl fluoride hydrochloride, p-APMSF

  • CAS Number 74938-88-8

  • Empirical Formula (Hill Notation) C8H9FN2O2S · HCl

  • Molecular Weight 252.69

  •  Beilstein Registry Number 9083148

  •  MDL number MFCD00078902

  •  PubChem Substance ID 329748248

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates, Organic Covalent Modifiers More...
InChI Key   KHLLRHIUKOJXLL-UHFFFAOYSA-N
assay   ≥97.0% (AT)
mp   ~205 °C (dec.)
storage temp.   −20°C

Description

Other Notes

An irreversible inhibitor of serine proteases

Application

APMSF was used to study the glucagon-receptor interaction; inhibition of cAMP formation led to the conclusion that there was a previously unexpected serine residue in the active site which may operate on the receptor by a mechanism similar to serine proteases.

Biochem/physiol Actions

Irreversible inhibitor of serine proteases with lysine or arginine substrate specificities. Effective concentration 10-100 μM. Frequently used to characterize newly discovered proteases.

Price and Availability


Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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