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105945 Sigma-Aldrich

Phenolphthalein

ACS reagent

Synonym: 3,3-Bis(4-hydroxyphenyl)-1(3H)-isobenzofuranone

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Cell Biology, Core Bioreagents, Hematology and Histology,
grade   ACS reagent
form   powder
visual transition interval   8.0 - 10, colorless to red
mp   261-263 °C(lit.)
solubility   acetone: soluble
absorption   λmax 374 nm (2nd)
  λmax 552 nm

Description

Packaging

100, 500 g in poly bottle

2.5 kg in poly drum

Application

Phenolphthalein is used as a general pH indicator. It is colorless in acidic solutions and turns pink in basic solutions. Phenolphthalein is also used as a model organic compound in the evaluation of the capture efficiency of various cyclodextrin constructs such as nanofiber-CD.

Price and Availability

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Phenolphthalein

pH indicator

Phenolphthalein

ACS reagent, reag. Ph. Eur., indicator, 98-102% (calc. to the dried substance), S. No.: 879

Phenolphthalein

puriss., meets analytical specification of Ph Eur., BP, 98-101% (calc. to the dried substance)

Phenolphthalein solution

2% in ethanol, indicator

Phenolphthalein solution

Reag. Ph. Eur., indicator, 1% in ethanol

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
Hazard Codes (Europe) 
T
Risk Statements (Europe) 
Safety Statements (Europe) 
53-45
WGK Germany 
3
RTECS 
SM8380000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

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Peer-Reviewed Papers

References

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Phenolphthalein Induces Thymic Lymphomas Accompanied by Loss of the p53 Wild Type Allele in Heterozygous p53-Deficient (±) Mice June K. Dunnick,Jerry F. Hardisty Toxicol. Pathol. 25(6), 533-540, (1997)

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Webcam camera as a detector for a simple lab-on-chip time based approach. Wongwilai W, Lapanantnoppakhun S, et. al. Talanta 81, 1137-1141, (2010)

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Physical-chemical parameters and validation of a colorimetric method for deoxycholic and ursodeoxycholic acids: kit reagent and optical sensor. Cadena PG, Araújo AN, et. al. Chem. Phys. Lipids 164, 99-105, (2011)

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Functional electrospun polystyrene nanofibers incorporating α-, β-, and γ-cyclodextrins: comparison of molecular filter performance. Uyar T, Havelund R, Hacaloglu J, et al. ACS Nano 4(9), 5121-30, (2010)

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On the mechanism of floating and sliding of liquid marbles. Bormashenko E, Bormashenko Y, Musin A, et al. ChemPhysChem 10(4), 654-6, (2009)

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Rabbit 3-hydroxyhexobarbital dehydrogenase is a NADPH-preferring reductase with broad substrate specificity for ketosteroids, prostaglandin D₂, and other endogenous and xenobiotic carbonyl compounds. Endo S, Matsunaga T, Matsumoto A, et al. Biochem. Pharmacol. 86(9), 1366-75, (2013)

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Phenolphthalein. Rep. Carcinog. 12, 342-4, (2011)

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Examination of seminal stain by HPLC assay of phenolphthalein. Yoshida M, Akane A, Mitani T, et al. Leg. Med. (Tokyo.) 11 Suppl 1, S357-9, (2009)

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Carbonaceous nanofiber membrane functionalized by beta-cyclodextrins for molecular filtration. Chen P, Liang HW, Lv XH, et al. ACS Nano 5(7), 5928-35, (2011)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Use of a pharmaceutically adulterated dietary supplement, Pai You Guo, among Brazilian-born women in the United States. Cohen PA, Benner C, and McCormick D J. Gen. Intern. Med. 27(1), 51-6, (2012)

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Analysis of adulterated herbal medicines and dietary supplements marketed for weight loss by DOSY 1H-NMR. Vaysse J, Balayssac S, Gilard V, et al. Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 27(7), 903-16, (2010)

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Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands. Dring AM, Anderson LE, Qamar S, et al. Chem. Biol. Interact. 188(3), 512-25, (2010)

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Rapid screening of illicit additives in weight loss dietary supplements with desorption corona beam ionisation (DCBI) mass spectrometry. Wang H, Wu Y, Zhao Y, et al. Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 29(8), 1194-201, (2012)

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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Naomi L Kruhlak et al Toxicol. Mech. Methods 18, 217-27, (2008)

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Identification of the Binding Modes of N-Phenylphthalimides Inhibiting Bacterial Thymidylate Synthase through X-Ray Crystallography Screening Mangani, S.; et al. J. Med. Chem. 54, 5454, (2011)

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The preparation and characterization of non-covalently functionalized graphene. Hu N, Gao R, Wang Y, et al. J. Nanosci. Nanotechnol. 12(1), 99-104, (2012)

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Evaluation of phenolphthalein, diazepam and quinacrine dihydrochloride in the in vitro mammalian cell micronucleus test in Chinese hamster ovary (CHO) and TK6 cells. Schuler M, Gudi R, Cheung J, et al. Mutat. Res. 702(2), 219-29, (2010)

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Liposome solubilization induced by surfactant molecules in a microchip. Shoji Y, Igarashi T, Nomura H, et al. Anal. Sci. 28(4), 339-43, (2012)

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Phenolphthalein induces centrosome amplification and tubulin depolymerization in vitro. Heard PL, Rubitski EE, Spellman RA, et al. Environ. Mol. Mutagen. 54(5), 308-16, (2013)

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A novel approach for determination of free fatty acids in vegetable oils by a flow injection system with manual injection. Ayyildiz HF, Kara H, and Sherazi ST Lipids 46(12), 1181-90, (2011)

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Alteration of expirated bloodstain patterns by Calliphora vicina and Lucilia sericata (Diptera: Calliphoridae) through ingestion and deposition of artifacts. Striman B, Fujikawa A, Barksdale L, et al. J. Forensic Sci. 56 Suppl 1, S123-7, (2011)

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No association between severe constipation with related drug treatment in pregnant women and congenital abnormalities in their offspring: A population-based case-control study. Acs N, Bánhidy F, Puhó EH, et al. Congenit. Anom. (Kyoto.) 50(1), 15-20, (2010)

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Simple determination of deoxycholic and ursodeoxycholic acids by phenolphthalein-beta-cyclodextrin inclusion complex. Cadena PG, Oliveira EC, Araújo AN, et al. Lipids 44(11), 1063-70, (2009)

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Phenolphthalein as a prototype drug for a group of structurally related calcium channel blockers in human platelets. Dobrydneva Y, Wilson E, Abelt CJ, et al. J. Cardiovasc. Pharmacol. 53(3), 231-40, (2009)

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Study on detection of drugs in slimming health foods using GC-MS/MS. Yamamoto S, Sumioka S, Fujioka M, et al. Shokuhin Eiseigaku Zasshi 52(6), 363-9, (2011)

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Highly selective determination of phenolphthalein by flow injection chemiluminescence method based on a molecular imprinting polymer. Yu J, Ge L, Dai P, et al. Luminescence 24(6), 444-7, (2009)

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More on fixed drug eruptions. Konotey-Ahulu FI BMJ 339, b2924, (2009)

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Movement away from phenolphthalein in laxatives. Murphy J JAMA 301(17), 1770; author reply 1770, (2009)

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Merck 14,7243

Beil. 18,V,4,188

FT-IR 2 (3), 4135:D / FT-IR 1 (2), 1006:B / IR-Spectra (2), 1268:H / IR-Spectra (3), 1471:C / RegBook 1 (2), 2783:A / Sax 6, 2165 / Sigma FT-IR 1 (2), 193:B / Stains and Dyes Ref, 563 / Structure Index 1, 442:B:4

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