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106232 Sigma-Aldrich

Trifluoroacetic anhydride

ReagentPlus®, ≥99%

Synonym: TFAA

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Properties

grade   ReagentPlus®
vapor pressure   6.28 psi ( 20 °C)
InChI Key   QAEDZJGFFMLHHQ-UHFFFAOYSA-N
assay   ≥99%
refractive index   n20/D 1.3(lit.)
bp   39.5-40 °C(lit.)
mp   −65 °C(lit.)
density   1.511 g/mL at 20 °C(lit.)

Description

Packaging

10×1 g in ampule

3 kg in glass bottle

25 kg in composite drum

25, 100, 4×100, 500 g in glass bottle

Application

For the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for GC analysis. Also used in the oxidation of aldehydes to acids, esters, or amides. Trifluoroacetic anhydride can undergo reaction with deoxyguanosine in pyridine to give the corresponding 6-substituted-2’-deoxyguanosine derivatives. It can also react with urea-hydrogen peroxide complex to generate peroxytrifluoroacetic acid, which can convert aldoximes to nitroalkanes.

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Supplemental Hazard Statements 
Reacts violently with water.
RIDADR 
UN 3265 8 / PGI
WGK Germany 
2
RTECS 
AJ9800000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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