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112909 Sigma-Aldrich

Ethyl 4-aminobenzoate

98%

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Properties

Related Categories Building Blocks, C8 to C9, Carbonyl Compounds, Chemical Synthesis, Esters,
assay   98%
mp   88-90 °C(lit.)

Description

Packaging

100, 500 g in poly bottle

5 g in glass bottle

Price and Availability

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Safety & Documentation

Safety Information

WGK Germany 
2
RTECS 
DG2450000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

Local anesthetic inhibition of a bacterial sodium channel. Lee S, Goodchild SJ, and Ahern CA J. Gen. Physiol. 139(6), 507-16, (2012)

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Molecular characteristics for solid-state limited solubility. Carola M Wassvik et al J. Med. Chem. 51, 3035-9, (2008)

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Extracellular quaternary ammonium blockade of transient receptor potential vanilloid subtype 1 channels expressed in Xenopus laevis oocytes. Rivera-Acevedo RE, Pless SA, Schwarz SK, et al. Mol. Pharmacol. 82(6), 1129-35, (2012)

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Lidocaine contact allergy is becoming more prevalent. To D, Kossintseva I, and de Gannes G Dermatol. Surg. 40(12), 1367-72, (2014)

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Central cyanosis on a psychiatric unit treated at the Salford Royal Hospital. Green D, Barry P, and Green HD Thorax 69(12), 1157-8, (2014)

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MAM-2201 (analytically confirmed) intoxication after "Synthacaine" consumption. Lonati D, Buscaglia E, Papa P, et al. Ann. Emerg. Med. 64(6), 629-32, (2014)

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Cetacaine induced methemoglobinemia: overview of analysis and treatment strategies. Khan R and Kuppaswamy BS W. V. Med. J. 109(3), 24-6, (2013)

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[Topical benzocaine. Warning]. Sabourin G Perspect. Infirm. 10(2), 62, (2013)

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Clinical efficacy of tetracaine anesthetic paste. Hopp C, Goebel W, Hildebolt C, et al. Gen. Dent. 60(2), e69-73, (2012)

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Atypical presentations of methemoglobinemia from benzocaine spray. Tantisattamo E, Suwantarat N, Vierra JR, et al. Hawaii Med. J. 70(6), 125-6, (2011)

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Intraoperative detection of methemoglobinemia in a patient given benzocaine spray to relieve discomfort from a nasogastric tube: a case report. Young B AANA J. 76(2), 99-102, (2008)

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Methemoglobinemia: a complication after fiberoptic orotracheal intubation with benzocaine spray. A case report. Ellis FD, Seiler JG, and Palmore MM J. Bone Joint Surg. Am. 77(6), 937-9, (1995)

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Monitoring unmet needs: using 2-1-1 during natural disasters. Bame SI, Parker K, Lee JY, et al. Am. J. Prev. Med. 43(6 Suppl 5), S435-42, (2012)

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Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Hong Wan et al J. Med. Chem. 52, 1693-700, (2009)

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Modification of crystallization behavior in drug/polyethylene glycol solid dispersions. Zhu Q, Harris MT, and Taylor LS Mol. Pharm. 9(3), 546-53, (2012)

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Severe methemoglobinemia complicating topical benzocaine use during endoscopy in a toddler: a case report and review of the literature. Dahshan A and Donovan GK Pediatrics 117(4), e806-9, (2006)

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Hydrophilic interaction liquid chromatography of anthranilic acid-labelled oligosaccharides with a 4-aminobenzoic acid ethyl ester-labelled dextran hydrolysate internal standard. Neville DC, Alonzi DS, and Butters TD J. Chromatogr. A 1233, 66-70, (2012)

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Benzocaine-induced methemoglobinemia: report of a severe reaction and review of the literature. Rodriguez LF, Smolik LM, and Zbehlik AJ Ann. Pharmacother. 28(5), 643-9, (1994)

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Organized polysaccharide fibers as stable drug carriers. Janaswamy S, Gill KL, Campanella OH, et al. Carbohydr. Polym. 94(1), 209-15, (2013)

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Benzocaine-loaded polymeric nanocapsules: study of the anesthetic activities. De Melo NF, De Araújo DR, Grillo R, et al. J. Pharm. Sci. 101(3), 1157-65, (2012)

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Methemoglobinemia induced by topical anesthetic (benzocaine). Linares LA, Peretz TY, and Chin J Radiother. Oncol. 18(3), 267-9, (1990)

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Effect of continuous versus interrupted administration of nitrous oxide-oxygen inhalation on behavior of anxious pediatric dental patients: a pilot study. Guelmann M, Brackett R, Beavers N, et al. J. Clin. Pediatr. Dent. 37(1), 77-82, (2012)

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QSAR-based solubility model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 18, 7078-84, (2010)

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Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins. Alfonso Pérez-Garrido et al Bioorg. Med. Chem. 17, 896-904, (2009)

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Effectiveness of two flavored topical anesthetic agents in reducing injection pain in children: a comparative study. Deepika A, Rao CR, Vinay C, et al. J. Clin. Pediatr. Dent. 37(1), 15-8, (2012)

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Transdermal delivery of butamben using elastic and conventional liposomes. Cereda CM, Franz-Montan M, da Silva CM, et al. J. Liposome Res. 23(3), 228-34, (2013)

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Benzocaine-induced methemoglobinemia in the pediatric population. Lehr J, Masters A, and Pollack B J. Pediatr. Nurs. 27(5), 583-8, (2012)

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Ligand-based design and synthesis of novel sodium channel blockers from a combined phenytoin-lidocaine pharmacophore. Yuesheng Wang et al Bioorg. Med. Chem. 17, 7064-72, (2009)

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Methemoglobinemia caused by benzocaine topical spray. Cooper HA South. Med. J. 90(9), 946-8, (1997)

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Pharmacokinetics of pirfenidone after topical administration in rabbit eye. Guoying Sun et al Mol. Vis. 17, 2191-6, (2011)

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Allergic contact dermatitis of the vulva. O'Gorman SM and Torgerson RR Dermatitis 24(2), 64-72, (2013)

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Effects of euthanasia method on stable-carbon and stable-nitrogen isotope analysis for an ectothermic vertebrate. Atwood MA Rapid Commun. Mass Spectrom. 27(8), 909-13, (2013)

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Contact allergy to local anaesthetics-value of patch testing with a caine mix in the baseline series. Brinca A, Cabral R, and Gonçalo M Contact Dermatitis 68(3), 156-62, (2013)

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Methemoglobinemia and benzocaine. Moos DD and Cuddeford JD Gastroenterol. Nurs. 30(5), 342-5; quiz 346-7, (2007)

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Relief of palatal injection pain by liposome-encapsulated 2% lignocaine prepared by ultrasonic dental scaler. Paphangkorakit J, Sangsirinakagul C, and Priprem A Br. J. Oral Maxillofac. Surg. 50(8), 784-7, (2012)

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Risk of topical anesthetic-induced methemoglobinemia: a 10-year retrospective case-control study. Chowdhary S, Bukoye B, Bhansali AM, et al. JAMA Intern. Med. 173(9), 771-6, (2013)

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Membrane permeable local anesthetics modulate Na(V)1.5 mechanosensitivity. Beyder A, Strege PR, Bernard C, et al. Channels (Austin.) 6(4), 308-16, (2012)

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Evaluation and management of acquired methemoglobinemia associated with topical benzocaine use. Taleb M, Ashraf Z, Valavoor S, et al. Am. J. Cardiovasc. Drugs 13(5), 325-30, (2013)

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Contact sensitization to the allergens of European baseline series in patients with chronic leg ulcers. Beliauskienė A, Valiukevičienė S, Sitkauskienė B, et al. Medicina (Kaunas.) 47(9), 480-5, (2011)

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Effect of the interfacial tension and ionic strength on the thermodynamic barrier associated to the benzocaine insertion into a cell membrane. López Cascales JJ and Oliveira Costa SD Biophys. Chem. 172, 1-7, (2013)

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Inhibition of sensory neuronal TRPs contributes to anti-nociception by butamben. Bang S, Yang TJ, Yoo S, et al. Neurosci. Lett. 506(2), 297-302, (2012)

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The in vitro and in vivo genotoxicity of benzocaine: a brief communication. Brock WJ and Bell TA Int. J. Toxicol. 31(3), 222-7, (2012)

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Determination of local anesthetics in illegal products using HPLC method with amperometric detection. Jadach M, Błazewicz A, and Fijalek Z Acta Pol. Pharm. 69(3), 397-403, (2012)

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Acute generalized exanthematous pustulosis associated with 2 common medications: hydroxyzine and benzocaine. O'Toole A, Lacroix J, Pratt M, et al. J. Am. Acad. Dermatol. 71(4), e147-9, (2014)

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Commentary. Harris NS, Bazydlo LA, and Winter WE Clin. Chem. 60(4), 599, (2014)

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Commentary. Abdelmoneim SS, Mankad S, and Mulvagh SL Clin. Chem. 60(4), 598-9, (2014)

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A 70-year-old man with blue skin. Shu I and Wang P Clin. Chem. 60(4), 595-8, (2014)

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JAAD Grand Rounds quiz. An erosive vulvar rash. Warner N, Salvaggio HL, and Zaenglein AL J. Am. Acad. Dermatol. 68(2), 350-2, (2013)

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Mitigating traumatic stress reactions in young people. Howard JM J. Child Adolesc. Psychopharmacol. 22(6), 408, (2012)

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Merck 14,1086

Beil. 14,422

Aldrich MSDS 1, 880:A / Corp MSDS 1 (1), 1571:A / FT-IR 2 (2), 2858:B / FT-IR 1 (2), 303:A / IR-Spectra (3), 1033:E / IR-Spectra (2), 904:F / NMR-Reference 2 (2), 287:D / RegBook 1 (2), 1911:J / Sax 6, 1318 / Sigma FT-IR 1 (1), 659:A / Structure Index 1, 306:D:8 / Vapor Phase 3, 1372:B

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