123226 Sigma-Aldrich


ReagentPlus®, 99%

Synonym: Methoxybenzene, Methyl phenyl ether



Related Categories ReagentPlus, ReagentPlus Solvent Grade Products, ACS and Reagent Grade Solvents, Amber Glass Bottles, Carbon Steel Cans with NPT Threads,
grade   ReagentPlus®
vapor density   3.7 (vs air)
vapor pressure   10 mmHg ( 42.2 °C)
assay   99%
autoignition temp.   887 °F
refractive index   n20/D 1.516(lit.)
bp   154 °C(lit.)
mp   −37 °C(lit.)
density   0.995 g/mL at 25 °C(lit.)


Other Notes

A -D suffix exists for administrative purposes only.
All -D packages are 100% the same product, same quality, same specification as the package sizes previously sold without a -D.


1, 4 L in glass bottle

100 mL in glass bottle

18, 20 L in steel drum

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability

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anhydrous, 99.7%

Diphenyl ether

≥99%, FG

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Precautionary statements 
UN 2222 3 / PGIII
WGK Germany 
Flash Point(F) 
123.8 °F
Flash Point(C) 
51 °C


Certificate of Analysis

Certificate of Origin

Protocols & Articles


Determination of Water Content in Anisole Using Karl Fischer Titration

Ethers behave similarly to hydrocarbons. They are mostly adequately soluble in methanol. Only long chain ethers require the addition of propanol or chloroform as solubilizers. Double bonds can someti...
Keywords: Titrations

Fluorescence Quenching Microscopy: Imaging Two-Dimensional Materials

Alane Lim and Jiaxing Huang* Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA *Email:
Keywords: Chemical vapor deposition, Deposition, Diffraction, Materials Science, Microscopy, Optical microscopy, Scanning electron microscopy, Solvents, Spectroscopy, Spin coating

Peer-Reviewed Papers


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Air-water exchange of anthropogenic and natural organohalogens on International Polar Year (IPY) expeditions in the Canadian Arctic. Wong F, Jantunen LM, Pućko M, et al. Environ. Sci. Technol. 45(3), 876-81, (2011)


Infrared laser ablation atmospheric pressure photoionization mass spectrometry. Vaikkinen A, Shrestha B, Kauppila TJ, et al. Anal. Chem. 84(3), 1630-6, (2012)


Unusual ipso substitution of diaryliodonium bromides initiated by a single-electron-transfer oxidizing process. Dohi T, Ito M, Yamaoka N, et al. Angew. Chem. Int. Ed. Engl. 49(19), 3334-7, (2010)


Reaction kinetics of selected micropollutants in ozonation and advanced oxidation processes. Jin X, Peldszus S, and Huck PM Water Res. 46(19), 6519-30, (2012)


Folding-promoted TBAX-mediated selective demethylation of methoxybenzene-based macrocyclic aromatic pentamers. Du Z, Qin B, Sun C, et al. Org. Biomol. Chem. 10(21), 4164-71, (2012)


Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bram Baert et al Bioorg. Med. Chem. 15, 6943-55, (2007)


Accelerated hole transfer across a molecular double barrier. Hanss D, Walther ME, and Wenger OS Chem. Commun. (Camb.) 46(37), 7034-6, (2010)


Low-cost fluorimetric determination of radicals based on fluorogenic dimerization of the natural phenol sesamol. Makino Y, Uchiyama S, Ohno K, et al. Anal. Chem. 82(4), 1213-20, (2010)


[Design, synthesis and evaluation of tacrine-methoxybenzene hybrids as cholinesterases inhibitors]. Luo W, Zhao YM, Zhang Z, et al. Yao Xue Xue Bao 47(7), 916-21, (2012)


Application of response surface method using rapid screening, support vector machine, and multiple regression on the acidity and activity of Si-Al-Zr ternary oxide. Omata K, Yamazaki Y, Kobayashi Y, et al. J. Comb. Chem. 12(4), 435-44, (2010)


Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Giulia Caron et al J. Med. Chem. 48, 3269-79, (2005)


Copper-catalyzed thiolation of the di- or trimethoxybenzene arene C-H bond with disulfides. Zhang S, Qian P, Zhang M, et al. J. Org. Chem. 75(19), 6732-5, (2010)


Evaluation of dispersive liquid-liquid microextraction for the simultaneous determination of chlorophenols and haloanisoles in wines and cork stoppers using gas chromatography-mass spectrometry. Campillo N, Viñas P, Cacho JI, et al. J. Chromatogr. A. 1217(47), 7323-30, (2010)


Surface catalysed Suzuki-Miyaura cross-coupling by Pd nanoparticles: an operando XAS study. Lee AF, Ellis PJ, Fairlamb IJ, et al. Dalton Trans. 39(43), 10473-82, (2010)


Determination of carotenoids by liquid chromatography/mass spectrometry: effect of several dopants. Rivera S, Vilaró F, and Canela R Anal. Bioanal. Chem 400(5), 1339-46, (2011)


Toward prediction of alkane/water partition coefficients. Anita Toulmin et al J. Med. Chem. 51, 3720-30, (2008)


Development and optimisation of a dopant assisted liquid chromatographic-atmospheric pressure photo ionisation-tandem mass spectrometric method for the determination of 15+1 EU priority PAHs in edible oils. Hollosi L and Wenzl T J. Chromatogr. A. 1218(1), 23-31, (2011)


QSPR models of n-octanol/water partition coefficients and aqueous solubility of halogenated methyl-phenyl ethers by DFT method. Zeng XL, Wang HJ, and Wang Y Chemosphere 86(6), 619-25, (2012)


Synthesis of a glycosylphosphatidylinositol anchor bearing unsaturated lipid chains. Swarts BM and Guo Z J. Am. Chem. Soc. 132(19), 6648-50, (2010)


High-resolution NMR spectroscopy in inhomogeneous fields via Hadamard-encoded intermolecular double-quantum coherences. Chen Y, Cai S, Cai C, et al. NMR Biomed. 25(9), 1088-94, (2012)


Transforming frozen self-assemblies of amphiphilic block copolymers into dynamic pH-sensitive micelles. Dutertre F, Boyron O, Charleux B, et al. Macromol. Rapid Commun. 33(9), 753-9, (2012)


Cyano bonded silica monolith--development of an in situ modification method for analytical scale columns. Soliven A, Dennis GR, Guiochon G, et al. J. Chromatogr. A. 1217(39), 6085-91, (2010)


Noncovalent interactions in the gas phase: the anisole-phenol complex. Pietraperzia G, Pasquini M, Mazzoni F, et al. J. Phys. Chem. A 115(34), 9603-11, (2011)


Discovery of estrogen receptor ? modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells. Li Liu et al Bioorg. Med. Chem. Lett. 22, 154-63, (2012)


Structure and vibrational frequencies of 6,7-dimethoxy-1,4-dihydro-1,3-quinoxalinedione based on density functional theory calculations: The role of pi-electron conjugation and back-donation. Krishnakumar V and Prabavathi N Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 77(1), 238-47, (2010)


Studies on percutaneous penetration of chemicals - Impact of storage conditions for excised human skin. Dennerlein K, Schneider D, Göen T, et al. Toxicol. In Vitro 27(2), 708-13, (2013)


Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins. Alfonso Pérez-Garrido et al Bioorg. Med. Chem. 17, 896-904, (2009)


Sulfonation of alkyl phenyl ether self-assembled monolayers. Katash I, Luo X, and Sukenik CN Langmuir 26(3), 1765-75, (2010)


3,4,4'-Trihydroxy-trans-stilbene, an analogue of resveratrol, is a potent antioxidant and cytotoxic agent. Cai W, Zhang L, Song Y, et al. Free Radic. Res. 45(11-12), 1379-87, (2011)


Resonance-enhanced two-photon ionization spectroscopy and theoretical calculations of 3,5-difluoroanisole and its Ar-containing complex. Zhang L, Dong C, Cheng M, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 96, 578-85, (2012)


Spectroscopic characterization studies of 1-methyl indole with benzene derivatives. Bakkialakshmi S, Shanthi B, and Shanthi M Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 77(1), 179-83, (2010)


Merck 14,669

Beil. 6,IV,548

Fieser 1,41

Aldrich MSDS 1, 129:B / Arctander, 246 / Corp MSDS 1 (1), 277:B / FT-IR 2 (2), 1776:A / FT-IR 1 (1), 1035:A / FT-NMR 1 (2), 175:A / Fenaroli / IR-Spectra (2), 556:A / IR-Spectra (3), 624:A / NMR-Reference 2 (1), 833:A / RegBook 1 (1), 1229:A / RegBook 46 (1), 1229:A / Sax 6, 285 / Sigma FT-IR 1 (2), 288:A / Structure Index 1, 188:A:1 / Vapor Phase 3, 963:A

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