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124737 Sigma-Aldrich

Glycolic acid

ReagentPlus®, 99%

Synonym: Hydroxyacetic acid

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Description

Packaging

12 kg in poly drum

25, 100, 500 g in poly bottle

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ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

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high purity, 70 wt. % in H2O

Glycolic acid solution

technical grade, 70 wt. % in H2O

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Hazard Codes (Europe) 
C
Risk Statements (Europe) 
Safety Statements (Europe) 
26-36/37/39-45
RIDADR 
UN 3261 8 / PGII
WGK Germany 
1
RTECS 
MC5250000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

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Peer-Reviewed Papers

References

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Formation of ZnMn2O4 ball-in-ball hollow microspheres as a high-performance anode for lithium-ion batteries. Zhang G, Yu L, Wu HB, et al. Adv. Mater. 24(34), 4609-13, (2012)

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Template-free synthesis of hierarchical vanadium-glycolate hollow microspheres and their conversion to V2O5 with improved lithium storage capability. Pan A, Zhu T, Wu HB, et al. Chemistry 19(2), 494-500, (2013)

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HMDB: a knowledgebase for the human metabolome. Wishart DS, Knox C, Guo AC, et al. Nucleic Acids Res. 37(Database issue), D603-10, (2009)

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Urinary oxalate and glycolate excretion in healthy infants and children. Leumann EP, Dietl A, and Matasovic A Pediatr. Nephrol. 4(5), 493-7, (1990)

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Age-related reference values for urinary organic acids in a healthy Turkish pediatric population. Guneral F and Bachmann C Clin. Chem. 40(6), 862-6, (1994)

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State of degradation in archeological oak from the 17th century Vasa ship: substantial strength loss correlates with reduction in (holo)cellulose molecular weight. Bjurhager I, Halonen H, Lindfors EL, et al. Biomacromolecules 13(8), 2521-7, (2012)

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Heparin-induced release of protein-bound solutes during hemodialysis is an in vitro artifact. De Smet R, Van Kaer J, Liebich H, et al. Clin. Chem. 47(5), 901-9, (2001)

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Prediction of skeletal muscle and fat mass in patients with advanced cancer using a metabolomic approach. Stretch C, Eastman T, Mandal R, et al. J. Nutr. 142(1), 14-21, (2012)

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Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bram Baert et al Bioorg. Med. Chem. 15, 6943-55, (2007)

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PLGG1, a plastidic glycolate glycerate transporter, is required for photorespiration and defines a unique class of metabolite transporters. Pick TR, Bräutigam A, Schulz MA, et al. Proc. Natl. Acad. Sci. U. S. A. 110(8), 3185-90, (2013)

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Plasma amino acid profile on nocturnal hemodialysis. Raj DS, Ouwendyk M, Francoeur R, et al. Blood Purif. 18(2), 97-102, (2000)

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Superficial micropeels: glycolic acid and alpha-hydroxy acid with kojic acid. Ellis DA, Tan AK, and Ellis CS Facial Plast. Surg. 11(1), 15-21, (1995)

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Tretinoin and glycolic acid treatment regimens. Hanke CW and Bullock SS Facial Plast. Surg. 11(1), 9-14, (1995)

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Automated, reproducible, titania-based phosphopeptide enrichment strategy for label-free quantitative phosphoproteomics. Richardson BM, Soderblom EJ, Thompson JW, et al. J. Biomol. Tech. 24(1), 8-16, (2013)

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Evaluation of serum fetuin-A relationships with biochemical parameters in patients on hemodialysis. Oikawa O, Higuchi T, Yamazaki T, et al. Clin. Exp. Nephrol. 11(4), 304-8, (2007)

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Accumulation of toxic products degradation of kynurenine in hemodialyzed patients. Pawlak D, Pawlak K, Malyszko J, et al. Int. Urol. Nephrol. 33(2), 399-404, (2001)

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Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease. Shoemaker JD and Elliott WH J. Chromatogr. A 562(1-2), 125-38, (1991)

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Quantitative analysis for organic acids in biological samples: batch isolation followed by gas chromatographic-mass spectrometric analysis. Hoffmann G, Aramaki S, Blum-Hoffmann E, et al. Clin. Chem. 35(4), 587-95, (1989)

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Ethylene glycol intoxication: evaluation of kinetics and crystalluria. Jacobsen D, Hewlett TP, Webb R, et al. Am. J. Med. 84(1), 145-52, (1988)

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A platform pathway for production of 3-hydroxyacids provides a biosynthetic route to 3-hydroxy-γ-butyrolactone. Martin CH, Dhamankar H, Tseng HC, et al. Nat. Commun. 4, 1414, (2013)

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Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations. McGregor DO, Dellow WJ, Lever M, et al. Kidney Int. 59(6), 2267-72, (2001)

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Ethylene glycol toxicity: the role of serum glycolic acid in hemodialysis. Porter WH, Rutter PW, Bush BA, et al. J. Toxicol. Clin. Toxicol. 39(6), 607-15, (2001)

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Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine. Gronwald W, Klein MS, Zeltner R, et al. Kidney Int. 79(11), 1244-53, (2011)

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Circulating concentrations of di(2-ethylhexyl) phthalate and its de-esterified phthalic acid products following plasticizer exposure in patients receiving hemodialysis. Pollack GM, Buchanan JF, Slaughter RL, et al. Toxicol. Appl. Pharmacol. 79(2), 257-67, (1985)

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Removal of the protein-bound solutes indican and p-cresol sulfate by peritoneal dialysis. Pham NM, Recht NS, Hostetter TH, et al. Clin. J. Am. Soc. Nephrol. 3(1), 85-90, (2008)

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Glycolate determination detects type I primary hyperoxaluria in dialysis patients. Marangella M, Petrarulo M, Bianco O, et al. Kidney Int. 39(1), 149-54, (1991)

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Prohormone-substrate peptide sequence recognition by peptidylglycine α-amidating monooxygenase and its reflection in increased glycolate inhibitor potency. Morris KM, Cao F, Onagi H, et al. Bioorg. Med. Chem. Lett. 22(23), 7015-8, (2012)

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Physiology and pathophysiology of organic acids in cerebrospinal fluid. Hoffmann GF, Meier-Augenstein W, Stöckler S, et al. J. Inherit. Metab. Dis. 16(4), 648-69, (1993)

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Asymmetric synthesis of diverse glycolic acid scaffolds via dynamic kinetic resolution of α-keto esters. Steward KM, Corbett MT, Goodman CG, et al. J. Am. Chem. Soc. 134(49), 20197-206, (2012)

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Ethylene glycol metabolism by Pseudomonas putida. Mückschel B, Simon O, Klebensberger J, et al. Appl. Environ. Microbiol. 78(24), 8531-9, (2012)

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Functional changes in human stratum corneum induced by topical glycolic acid: comparison with all-trans retinoic acid. Effendy I, Kwangsukstith C, Lee JY, et al. Acta Derm. Venereol. 75(6), 455-8, (1995)

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Thiamine deficiency and unexplained encephalopathy in hemodialysis and peritoneal dialysis patients. Hung SC, Hung SH, Tarng DC, et al. Am. J. Kidney Dis. 38(5), 941-7, (2001)

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Bile acid metabolism in extrahepatic biliary atresia: lithocholic acid in stored dried blood collected at neonatal screening. Gustafsson J, Alvelius G, Björkhem I, et al. Ups. J. Med. Sci. 111(1), 131-6, (2006)

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Intracellular proton-mediated activation of TRPV3 channels accounts for the exfoliation effect of α-hydroxyl acids on keratinocytes. Cao X, Yang F, Zheng J, et al. J. Biol. Chem. 287(31), 25905-16, (2012)

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Effects of glycolic acid on desquamation-regulating proteinases in human stratum corneum. Horikoshi T, Matsumoto M, Usuki A, et al. Exp. Dermatol. 14(1), 34-40, (2005)

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Correlations of ion structure with multiple fragmentation pathways arising from collision-induced dissociations of selected α-hydroxycarboxylic acid anions. Greene LE, Grossert JS, and White RL J. Mass Spectrom. 48(3), 312-20, (2013)

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Mode of action: oxalate crystal-induced renal tubule degeneration and glycolic acid-induced dysmorphogenesis--renal and developmental effects of ethylene glycol. Corley RA, Meek ME, and Carney EW Crit. Rev. Toxicol. 35(8-9), 691-702, (2005)

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Interference of ethylene glycol with (L)-lactate measurement is assay-dependent. Tintu A, Rouwet E, and Russcher H Ann. Clin. Biochem. 50(Pt 1), 70-2, (2013)

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Clinical improvement of photoaged skin with 50% glycolic acid. A double-blind vehicle-controlled study. Newman N, Newman A, Moy LS, et al. Dermatol. Surg. 22(5), 455-60, (1996)

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Identification and quantification of diadenosine polyphosphate concentrations in human plasma. Jankowski J, Jankowski V, Laufer U, et al. Arterioscler. Thromb. Vasc. Biol. 23(7), 1231-8, (2003)

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Clinical toxicologic implications of ethylene glycol and glycolic acid poisoning. Fraser AD Ther. Drug Monit. 24(2), 232-8, (2002)

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Plasma and urine glycolate assays for differentiating the hyperoxaluria syndromes. Marangella M, Petrarulo M, Vitale C, et al. J. Urol. 148(3 Pt 2), 986-9, (1992)

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Clinical and histological effects of glycolic acid at different concentrations and pH levels. DiNardo JC, Grove GL, and Moy LS Dermatol. Surg. 22(5), 421-4, (1996)

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Sulfated and nonsulfated bile acids in urine of patients with biliary atresia: analysis of bile acids by high-performance liquid chromatography. Nittono H, Obinata K, Nakatsu N, et al. J. Pediatr. Gastroenterol. Nutr. 5(1), 23-9, (1986)

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Synthesis of graft copolymer (CgOH-g-AGA): physicochemical properties, characterization and application. Sand A, Mishra DK, Pandey VS, et al. Carbohydr. Polym. 90(2), 901-7, (2012)

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Glycolic acid treatment increases type I collagen mRNA and hyaluronic acid content of human skin. Bernstein EF, Lee J, Brown DB, et al. Dermatol. Surg. 27(5), 429-33, (2001)

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Simultaneous determination of ethylene glycol and glycolic acid in serum by gas chromatography-mass spectrometry. Porter WH, Rutter PW, and Yao HH J. Anal. Toxicol. 23(7), 591-7, (1999)

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Glycolic acid inhibits enzymatic, hemorrhagic and edema-inducing activities of BaP1, a P-I metalloproteinase from Bothrops asper snake venom: insights from docking and molecular modeling. Pereañez JA, Patiño AC, Rey-Suarez P, et al. Toxicon 71, 41-8, (2013)

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Methane production from glycolate excreting algae as a new concept in the production of biofuels. Günther A, Jakob T, Goss R, et al. Bioresour. Technol. 121, 454-7, (2012)

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Plasma histamine in patients with chronic renal failure and nephrotic syndrome. Gill DS, Fonseca VA, Barradas MA, et al. J. Clin. Pathol. 44(3), 243-5, (1991)

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A comparative study on efficacy of high and low fluence Q-switched Nd:YAG laser and glycolic acid peel in melasma. Kar HK, Gupta L, and Chauhan A Indian J. Dermatol. Venereol. Leprol. 78(2), 165-71, (2012)

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Catalytic biofilms on structured packing for the production of glycolic acid. Li XZ, Hauer B, and Rosche B J. Microbiol. Biotechnol. 23(2), 195-204, (2013)

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Development of amperometric biosensors for the determination of glycolic acid in real samples. Tsiafoulis CG, Prodromidis MI, and Karayannis MI Anal. Chem. 74(1), 132-9, (2002)

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Photosynthesis, photorespiration and productivity of wheat and soybean genotypes. Aliyev JA Physiol. Plant. 145(3), 369-83, (2012)

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The use of glycolic acid as a peeling agent. Murad H, Shamban AT, and Premo PS Dermatol. Clin. 13(2), 285-307, (1995)

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Radioimmunoassay of serum glycocholic acid, standard laboratory tests of liver function and liver biopsy findings: comparative study of children with liver disease. Matsui A, Psacharopoulos HT, Mowat AP, et al. J. Clin. Pathol. 35(9), 1011-7, (1982)

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An inherited metabolic disorder presenting as ethylene glycol intoxication in a young adult. Pien K, van Vlem B, van Coster R, et al. Am. J. Forensic Med. Pathol. 23(1), 96-100, (2002)

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Glycolic acid functionalized chitosan-Au-Fe₃O₄ hybrid nanoparticle based nanohybrid scaffold for drug delivery. Kumari S and Singh RP Int. J. Biol. Macromol. 54, 244-9, (2013)

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Effects of topicals on the aging skin process. Thomas JR, Dixon TK, and Bhattacharyya TK Facial Plast. Surg. Clin. North Am. 21(1), 55-60, (2013)

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RALGA (Diacneal), a retinaldehyde and glycolic acid association and postinflammatory hyperpigmentation in acne--a review. Katsambas AD Dermatology 210 Suppl 1, 39-45, (2005)

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Comparison of the metabolism of ethylene glycol and glycolic acid in vitro by precision-cut tissue slices from female rat, rabbit and human liver. Booth ED, Dofferhoff O, Boogaard PJ, et al. Xenobiotica 34(1), 31-48, (2004)

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Adhesion and proliferation of human osteoblast-like cells on different biodegradable implant materials used for graft fixation in ACL-reconstruction. Bernstein A, Tecklenburg K, Südkamp P, et al. Arch. Orthop. Trauma Surg. 132(11), 1637-45, (2012)

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Glycolic acid-g-chitosan-Pt-Fe3O4 nanoparticles nanohybrid scaffold for tissue engineering and drug delivery. Kumari S and Singh RP Int. J. Biol. Macromol. 51(1-2), 76-82, (2012)

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Major factors modulating the serum oxalic acid level in hemodialysis patients. Ogawa Y, Machida N, Jahana M, et al. Front. Biosci. 9, 2901-8, (2004)

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A single-blinded comparative study between the use of glycolic acid 70% peel and the use of topical nanosome vitamin C iontophoresis in the treatment of melasma. Sobhi RM and Sobhi AM J. Cosmet. Dermatol. 11(1), 65-71, (2012)

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Vitamin A and zinc status in patients on maintenance haemodialysis. Cabral PC, Diniz Ada S, and de Arruda IK Nephrology (Carlton.) 10(5), 459-63, (2005)

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Evaluation of 70% glycolic peels versus 15% trichloroacetic peels for the treatment of photodamaged facial skin in aging women. Kubiak M, Mucha P, Dębowska R, et al. Dermatol. Surg. 40(8), 883-91, (2014)

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Open-label evaluation of the skin-brightening efficacy of a skin-brightening system using decapeptide-12. Kassim AT, Hussain M, and Goldberg DJ J. Cosmet. Laser Ther. 14(2), 117-21, (2012)

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The use of fillers and botulinum toxin type A in combination with superficial glycolic acid (alpha-hydroxy acid) peels: optimizing injection therapy with the skin-smoothing properties of peels. Rendon MI, Effron C, and Edison BL Cutis. 79(1 Suppl Combining), 9-12, (2007)

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Enhancing cosmetic outcomes by combining superficial glycolic acid (alpha-hydroxy acid) peels with nonablative lasers, intense pulsed light, and trichloroacetic acid peels. Effron C, Briden ME, and Green BA Cutis. 79(1 Suppl Combining), 4-8, (2007)

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Hyaluronic acid: additional biochemical marker in the diagnosis of biliary atresia. Ukarapol N, Wongsawasdi L, Ong-Chai S, et al. Pediatr. Int. 49(5), 608-11, (2007)

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[Neurotoxic role of glycocolle and derivatives in transurethral resection of the prostate]. Mahul P, Molliex S, Auboyer C, et al. Ann. Fr. Anesth. Reanim. 12(5), 512-4, (1993)

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Cytotoxic effect of paclitaxel incorporated in nanoparticles based on lactic and glycolic acid copolymer. Bojat V, Baranov DS, Oganesyan EA, et al. Bull. Exp. Biol. Med. 151(3), 340-3, (2011)

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Perspectives in carbohydrate toxicology with special reference to carcinogenicity. Roe FJ Swed. Dent. J. 8(3), 99-111, (1984)

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Progressive changes in glycine and glycine derivatives in plasma and cerebrospinal fluid after transurethral prostatic resection. Périer C, Mahul P, Molliex S, et al. Clin. Chem. 36(12), 2152-3, (1990)

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A superficial texture analysis of 70% glycolic acid topical therapy and striae distensae. Mazzarello V, Farace F, Ena P, et al. Plast. Reconstr. Surg. 129(3), 589e-590e, (2012)

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Liver donation after ethylene glycol overdose: when is it safe? McClain J, Uemura T, Sathishkumar S, et al. Transpl. Int. 25(4), e55-7, (2012)

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Merck 14,4498

Beil. 3,IV,571

Aldrich MSDS 1, 994:D / Corp MSDS 1 (1), 1791:A / FT-IR 2 (1), 805:B / FT-IR 1 (1), 517:A / FT-NMR 1 (1), 807:B / IR-Spectra (3), 302:H / IR-Spectra (2), 273:F / NMR-Reference 2 (1), 451:A / RegBook 1 (1), 565:A / Sax 6, 1482 / Structure Index 1, 80:C:7

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