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12805 Sigma-Aldrich

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate

purum, ≥97.0% (TLC)

Synonym: PyBOP®

  • CAS Number 128625-52-5

  • Linear Formula C18H28N6OP · PF6

  • Molecular Weight 520.39

  •  Beilstein Registry Number 3584612

  •  MDL number MFCD00077411

  •  PubChem Substance ID 329749882

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Properties

Related Categories Chemical Biology, Chemical Synthesis, Peptide Chemistry, Peptide Coupling, Phosphonium/Uronium/Formamidinium More...
InChI Key   VIAFLMPQBHAMLI-UHFFFAOYSA-N
grade   purum
assay   ≥97.0% (TLC)
mp   ~150 °C
  154-156 °C (dec.)(lit.)
storage temp.   2-8°C

Description

Application

Analogue of the BOP coupling reagent which does not form carcinogenic HMPA as by-product.

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) may be used in the following studies:
• As coupling reagent in the preparation strategies for peptide-oligonucleotide conjugates.
• Synthesis of structured pure triacylglycerol (TAG) regioisomers.
• As coupling reagent in the synthesis of a 3,5-pyrazolidinedione on soluble polyethylene glycol (PEG) polymer support.
• Synthesis of herceptin- nanoparticles.

General description

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) is an activator of carboxyl group commonly used in peptide synthesis. It also participates in the carboxylic acid esterification. It shows characteristics similar to benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and can be utilized as an alternative to BOP in peptide bond formation.

Legal Information

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

Price and Availability


Laboratory Gloves

Cross-Coupling Guide
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

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Peer-Reviewed Papers
15

References

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