• USA Home
  • 12805 - (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate

EMAIL THIS PAGE TO A FRIEND
12805 Sigma-Aldrich

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate

purum, ≥97.0% (TLC)

Synonym: PyBOP®

  • CAS Number 128625-52-5

  • Linear Formula C18H28N6OP · PF6

  • Molecular Weight 520.39

  •  Beilstein Registry Number 3584612

  •  MDL number MFCD00077411

  •  PubChem Substance ID 24847818

Purchase

Properties

Related Categories Chemical Biology, Chemical Synthesis, Peptide Chemistry, Peptide Coupling, Phosphonium/Uronium/Formamidinium More...
InChI Key   VIAFLMPQBHAMLI-UHFFFAOYSA-N
grade   purum
assay   ≥97.0% (TLC)
mp   ~150 °C
  154-156 °C (dec.)(lit.)
storage temp.   2-8°C

Description

Application

Analogue of the BOP coupling reagent which does not form carcinogenic HMPA as by-product.

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) may be used in the following studies:
• As coupling reagent in the preparation strategies for peptide-oligonucleotide conjugates.
• Synthesis of structured pure triacylglycerol (TAG) regioisomers.
• As coupling reagent in the synthesis of a 3,5-pyrazolidinedione on soluble polyethylene glycol (PEG) polymer support.
• Synthesis of herceptin- nanoparticles.

Other Notes

Same product — same quality — now Sigma-Aldrich brand

General description

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) is an activator of carboxyl group commonly used in peptide synthesis. It also participates in the carboxylic acid esterification. It shows characteristics similar to benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and can be utilized as an alternative to BOP in peptide bond formation.

Legal Information

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




Cross-Coupling Guide
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Related Content

COMU – Safer and More Efficient Peptide Coupling Reagent

Peptide synthesis relies heavily on efficient and reliable coupling reagents. A low tendency for racemization is a key requirement. This is especially true for solid phase peptide synthesis—quantitat...
Keywords: Building blocks, Calorimetry, Catalog, Condensations, Coupling reactions, Epimerizations, Methods, PEGylations, Peptide synthesis, Protocols, Racemizations, Search, Solid phase peptide synthesis, Solvents, Tools

Peer-Reviewed Papers
15

References

Set your institution to view full text papers.
Related Products

related product

Product #

Description

Add to Cart

08168 Timestrip Plus 8 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?