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  • 12809 - O-(Benzotriazol-1-yl)-N,N,N′,N′-bis(tetramethylene)uronium hexafluorophosphate

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12809 Sigma-Aldrich

O-(Benzotriazol-1-yl)-N,N,N′,N′-bis(tetramethylene)uronium hexafluorophosphate

≥98.0%

Synonym: (Benzotriazol-1-yloxy)dipyrrolidinocarbenium hexafluorophosphate, HBPyU

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Properties

Related Categories Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry, Peptide Coupling,
InChI Key   XKTRAGMCMJYRRN-UHFFFAOYSA-N
assay   ≥98.0%
mp   176 °C (dec.)(lit.)
solubility   acetonitrile: soluble0.1 g/mL, clear
storage temp.   2-8°C

Description

Other Notes

Recent studies show that crystal and solution structure of this coupling agent is a guanidinium N-oxide and not an uronium compound; Non-hygroscopic, extremely reactive reagent for peptide coupling giving low racemization. Reaction by-products are non-cytotoxic

Packaging

5 g in glass bottle

Application

Catalyst for synthesis of dyes

Reagent for peptide coupling

Price and Availability


Laboratory Gloves

Cross-Coupling Guide
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

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Peer-Reviewed Papers
15

References

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