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14606 Sigma-Aldrich

Cholesterol

tested according to Ph.Eur.

Synonym: 3β-Hydroxy-5-cholestene, 5-Cholesten-3β-ol, Cholesterolum

  • CAS Number 57-88-5

  • Empirical Formula (Hill Notation) C27H46O

  • Molecular Weight 386.65

  •  Beilstein Registry Number 1915888

  •  EC Number 200-353-2

  •  MDL number MFCD00003646

  •  PubChem Substance ID 24848759

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Properties

Related Categories Analytical/Chromatography, Asymmetric Synthesis, Biochemicals and Reagents, Chemical Synthesis, Chiral Building Blocks,
InChI Key   HVYWMOMLDIMFJA-DPAQBDIFSA-N
form   powder
pharmacopeia   testing conforms to Pharmacopeia
bp   360 °C(lit.)
mp   147-149 °C(lit.)
solubility   chloroform: soluble1 gm in 4.5 ml
  diethyl ether: soluble1 gm in 2.8 ml
  pyridine: soluble1 gm in 1.5 ml
  H2O: insoluble
  acetone: soluble
  alcohol: slightly soluble
  alcohol: very soluble (Hot)
  benzene: soluble
  dioxane: soluble
  ethyl acetate: soluble
  hexane: soluble
  oil: soluble
  petroleum ether: soluble
density   1.067 g/mL at 25 °C(lit.)
storage temp.   2-8°C
Gene Information   human ... POLA1(5422), TOP2A(7153)
rat ... Ar(24208), Polb(29240)

Description

Biochem/physiol Actions

Major component of all biological membranes; ~25% of total brain lipid is cholesterol.

Cholesterol is a lipid that makes up about 20-25% of the structural components of the cell membranes. It determines the fluidity and permeability of the membrane, making it permeable to water but not to ions and protons. Cholesterol also regulates the functions of the transporters and signaling proteins present on the plasma membrane. The major sites of cholesterol synthesis are small intestine and liver.

Other Notes

Same product — same quality — now Sigma-Aldrich brand

Application

Cholesterol was used for preparing ISCOMS containing ovalbumin (OVA) for studying whether the incorporation of the protein antigen ovalbumin (OVA) in lipophilic immune-stimulating complexes (ISCOMS) induces very strong primary immune responses. It was incorporated in animal feed to study the effect of cholesterol-rich diet.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
FZ8400000
Protocols & Articles
Peer-Reviewed Papers
15

References

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