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15222 Sigma-Aldrich

N,O-Bis(trimethylsilyl)trifluoroacetamide

for GC derivatization, ≥99.0%

Synonym: BSTFA

  • CAS Number 25561-30-2

  • Linear Formula CF3C[=NSi(CH3)3]OSi(CH3)3

  • Molecular Weight 257.40

  •  Beilstein Registry Number 2050024

  •  EC Number 247-103-9

  •  MDL number MFCD00008269

  •  PubChem Substance ID 329750779

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Biochemicals and Reagents, Derivatization Reagents, Derivatization Reagents GC,
grade   for GC derivatization
InChI Key   XCOBLONWWXQEBS-KPKJPENVSA-N
assay   ≥99.0% (GC)
  ≥99.0%
refractive index   n20/D 1.384(lit.)
  n20/D 1.384
bp   45-50 °C/14 mmHg(lit.)
density   0.969 g/mL at 25 °C(lit.)

Description

Packaging

1, 10×1, 5, 25 mL in glass bottle

Application

BSTFA + 1% TMCS (trimethylsilyl) in ethyl acetate, acetonitrile and dichloromethane solvents may be used for silylation of steroid hormone 17a-ethinylestradiol (EE2) using gas chromatography-mass spectrometry (GC-MS). It may also be used for silylation of endogenous 2-monoglyceride, present in canine gut that binds to cannabinoid receptors.

General description

N,O-Bis(trimethylsilyl)trifluoroacetamide (BSTFA) is an excellent silylation reagent. For some sterically hindered primary or secondary nitro compounds, N,O-bis(trimethylsilyl)acetamide and BSTFA achieve better results than normal silylation conditions. BSTFA finds application in derivatizing amines. It is suitable for silyaltion of carboxylic acids, phenols, ureas, amides and alcohols.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2924 8(3) / PGIII
WGK Germany 
3
Flash Point(F) 
75.2 °F
Flash Point(C) 
24 °C
Protocols & Articles

Articles

Silylating Reagents for GC-MS Compatible Derivatives of NSAIDs

Human and veterinary pharmaceuticals are a group of “emerging” contaminants,1, 2 some of which are produced in increasingly large volumes every year. The amounts produced are reaching quantities simi...
Luis-Alberto Martin
AnalytiX Volume 10 Article 2
Keywords: Anti-inflammatory agents, Derivatizations, Environmental, Gas chromatography, Gas chromatography mass spectrometry, Mass spectrometry, Metabolites, Pesticides, Pharmaceutical, Silylations, Veterinary

Peer-Reviewed Papers
15

References

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